scholarly journals Axonal Protection by Netarsudil, a ROCK Inhibitor, Is Linked to an AMPK-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration

2022 ◽  
Vol 63 (1) ◽  
pp. 4
Author(s):  
Yasushi Kitaoka ◽  
Kana Sase ◽  
Chihiro Tsukahara ◽  
Naoki Fujita ◽  
Ibuki Arizono ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Degeneration ◽  
Rock Inhibitor ◽  
Autophagy Pathway ◽  
Optic Nerve Degeneration

scholarly journals Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration

2020 ◽  
Vol 57 (12) ◽  
pp. 4952-4960
Author(s):  
Yasushi Kitaoka ◽  
Kana Sase ◽  
Chihiro Tsukahara ◽  
Naoki Fujita ◽  
Ibuki Arizono ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cells ◽  
Immunohistochemical Analysis ◽  
Nerve Fibers ◽  
Nerve Degeneration ◽  
Autophagic Flux ◽  
Nicotinamide Riboside ◽  
Axon Loss ◽  
Autophagy Pathway ◽  
Optic Nerve Degeneration

Abstract Nicotinamide adenine dinucleotide (NAD+) synthesis pathway has been involved in many biological functions. Nicotinamide riboside (NR) is widely used as an NAD+ precursor and known to increase NAD+ level in several tissues. The present study aimed to examine the effect of NR on tumor necrosis factor (TNF)-induced optic nerve degeneration and to investigate whether it alters SIRT1 expression and autophagic status in optic nerve. We also examined the localization of nicotinamide riboside kinase 1 (NRK1), which is a downstream enzyme for NR biosynthesis pathway in retina and optic nerve. Intravitreal injection of TNF or TNF plus NR was performed on rats. The p62 and LC3-II protein levels were examined to evaluate autophagic flux in optic nerve. Immunohistochemical analysis was performed to localize NRK1 expression. Morphometric analysis showed substantial axonal protection by NR against TNF-induced axon loss. TNF-induced increment of p62 protein level was significantly inhibited by NR administration. NR administration alone significantly increased the LC3-II levels and reduced p62 levels compared with the basal levels, and upregulated SIRT1 levels in optic nerve. Immunohistochemical analysis showed that NRK1 exists in retinal ganglion cells (RGCs) and nerve fibers in retina and optic nerve. NR administration apparently upregulated NRK1 levels in the TNF-treated eyes as well as the control eyes. Pre-injection of an SIRT1 inhibitor resulted in a significant increase of p62 levels in the NR plus TNF treatment group, implicating that SIRT1 regulates autophagy status. In conclusion, NRK1 exists in RGCs and optic nerve axons. NR exerted protection against axon loss induced by TNF with possible involvement of upregulated NRK1 and SIRT1-autophagy pathway.

scholarly journals Retinal and optic nerve degeneration in α-mannosidosis

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Juliane Matlach ◽  
Thea Zindel ◽  
Yasmina Amraoui ◽  
Laila Arash-Kaps ◽  
Julia B. Hennermann ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Degeneration ◽  
Optic Nerve Degeneration

scholarly journals Neuroglobin effectively halts vision loss in Harlequin mice at an advanced stage of optic nerve degeneration

2021 ◽  
pp. 105483
Author(s):  
Hélène Cwerman-Thibault ◽  
Christophe Lechauve ◽  
Vassilissa Malko-Baverel ◽  
Sébastien Augustin ◽  
Gwendoline Le Guilloux ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Vision Loss ◽  
Nerve Degeneration ◽  
Advanced Stage ◽  
Optic Nerve Degeneration

TNF-α-Induced Optic Nerve Degeneration and Nuclear Factor-κB p65

2006 ◽  
Vol 47 (4) ◽  
pp. 1448 ◽  
Author(s):  
Yasushi Kitaoka ◽  
Yuka Kitaoka ◽  
Jacky M. K. Kwong ◽  
Fred N. Ross-Cisneros ◽  
Jiantao Wang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nuclear Factor Κb ◽  
Nerve Degeneration ◽  
Nuclear Factor ◽  
Tnf Α ◽  
Optic Nerve Degeneration

Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate-induced retinal damage in mice

2012 ◽  
Vol 90 (10) ◽  
pp. 1960-1969 ◽  
Author(s):  
Masamitsu Shimazawa ◽  
Akinori Miwa ◽  
Yasushi Ito ◽  
Kazuhiro Tsuruma ◽  
Makoto Aihara ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Optic Nerve ◽  
Endoplasmic Reticulum Stress ◽  
Nerve Degeneration ◽  
Retinal Damage ◽  
Optic Nerve Degeneration

Early postnatal Müller cell death leads to retinal but not optic nerve degeneration in NSE-Hu-Bcl-2 transgenic mice

Neuroscience ◽  
1999 ◽  
Vol 95 (1) ◽  
pp. 9-21 ◽  
Author(s):  
M. Dubois-Dauphin ◽  
C. Poitry-Yamate ◽  
F. de Bilbao ◽  
A.K. Julliard ◽  
F. Jourdan ◽  
...  
Keyword(s):  
Cell Death ◽  
Optic Nerve ◽  
Transgenic Mice ◽  
Müller Cell ◽  
Nerve Degeneration ◽  
Muller Cell ◽  
Optic Nerve Degeneration
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