scholarly journals Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma

2022 ◽  
Vol 63 (1) ◽  
pp. 16
Author(s):  
Rory Murphy ◽  
Mustapha Irnaten ◽  
Alan Hopkins ◽  
Jeffrey O'Callaghan ◽  
W. Daniel Stamer ◽  
...  
Keyword(s):  
Lamina Cribrosa

scholarly journals Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Elizabeth M McElnea ◽  
Emily Hughes ◽  
Aloysius McGoldrick ◽  
Amanda McCann ◽  
Barry Quill ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Lipofuscin Accumulation

scholarly journals Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma

2011 ◽  
Vol 52 (10) ◽  
pp. 7109 ◽  
Author(s):  
Hongli Yang ◽  
Galen Williams ◽  
J. Crawford Downs ◽  
Ian A. Sigal ◽  
Michael D. Roberts ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Experimental Glaucoma ◽  
Outward Migration

scholarly journals Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects

Ophthalmology ◽  
2017 ◽  
Vol 124 (11) ◽  
pp. 1600-1611 ◽  
Author(s):  
Yu Sawada ◽  
Makoto Araie ◽  
Makoto Ishikawa ◽  
Takeshi Yoshitomi
Keyword(s):  
Visual Field ◽  
Lamina Cribrosa ◽  
Visual Field Defects ◽  
Field Defects

Association of systemic cardio-vasculature status with retinal vascular endothelium in diabetes

2020 ◽  
Vol 1 (1) ◽  
pp. 52-57
Author(s):  
Galina Dimitrova ◽  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Arterial Stiffness ◽  
Vascular Endothelium ◽  
Lamina Cribrosa ◽  
Central Retinal Artery ◽  
Diabetic Patients ◽  
Retinal Artery ◽  
Central Retinal Vein

The relationship between diabetic retinopathy and macro-vascular complications in diabetes suggests a pathogenic association between these conditions. Vascular endothelium has been identified as a main site of blood vessel injury in diabetes. Diabetic retinopathy is associated with systemic arterial stiffness and altered vascular endothelium function and structure. Retinal vasculature endothelium at the macula, arterio-venous crossings, and in the optic nerve at the lamina cribrosa region is reported to differ from the endothelium in the rest of the retinal blood vessels. The central retinal artery and vein are in close proximity in the optic nerve where they share a common adventitia; thus, increased arterial wall stiffness and thickness may affect blood flow in the neighboring central retinal vein in this region. Moreover, increased arterial stiffness in small arterial beds is associated with retinal venular widening; it suggests the possibility of central retinal artery compressing the central retinal vein at the lamina cribrosa, thereby compromising venular outflow in the retina of diabetic patients. Altered blood flow in the central retinal vein in the postlaminar region has been detected in patients who experience progression of diabetic retinopathy. Increased hydrostatic pressure in the central retinal vein may play a major role in the pathogenesis of diabetic retinopathy. The aim of this review article is to emphasize this pathogenetic mechanism that has often been overlooked.

The Cytoskeletal Ultrastructure of Guinea Pig Optic Nerve at the Lamina Cribrosa

1992 ◽  
Vol 1 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Masashi Furuta ◽  
James D. Lindsey ◽  
Robert N. Weinreb
Keyword(s):  
Optic Nerve ◽  
Guinea Pig ◽  
Lamina Cribrosa
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