scholarly journals Longitudinal In Vivo Changes in Radial Peripapillary Capillaries and Optic Nerve Head Structure in Non-Human Primates With Early Experimental Glaucoma

2022 ◽  
Vol 63 (1) ◽  
pp. 10
Author(s):  
Gwen Musial ◽  
Suman Adhikari ◽  
Hanieh Mirhajianmoghadam ◽  
Hope M. Queener ◽  
Alexander W. Schill ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Experimental Glaucoma

scholarly journals In Vivo Changes in Lamina Cribrosa Microarchitecture and Optic Nerve Head Structure in Early Experimental Glaucoma

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134223 ◽  
Author(s):  
Kevin M. Ivers ◽  
Nripun Sredar ◽  
Nimesh B. Patel ◽  
Lakshmi Rajagopalan ◽  
Hope M. Queener ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Experimental Glaucoma

scholarly journals Longitudinal in vivo changes in radial peripapillary capillaries and optic nerve head structure in non-human primates with early experimental glaucoma

2021 ◽  
Author(s):  
Gwen Musial ◽  
Suman Adhikari ◽  
Hanieh Mirhajianmoghadam ◽  
Hope M Queener ◽  
Alexander W Schill ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Adaptive Optics ◽  
Optic Nerve Head ◽  
Time Course ◽  
Neuronal Loss ◽  
Lamina Cribrosa ◽  
Fiber Layer ◽  
Experimental Glaucoma ◽  
Nerve Fiber Layer Thickness

Purpose: There is conflicting evidence as to whether a loss of radial peripapillary capillaries (RPCs) precedes neuronal loss in glaucoma. We examined the time-course of in vivo changes in RPCs, optic nerve head (ONH) structure, and retinal nerve fiber layer thickness (RNFLT) in experimental glaucoma (EG). Methods: Spectral domain optical coherence tomography images were acquired before and approximately every 2 weeks after inducing unilateral EG in 9 rhesus monkeys to quantify mean anterior lamina cribrosa surface depth (ALCSD), minimum rim width (MRW), and RNFLT. Perfused RPC density was measured from adaptive optics scanning laser ophthalmoscope images acquired on the temporal half of the ONH. The time of first significant change was quantified as when values fell and remained outside of the 95% confidence interval established from control eyes. Results: Mean ALCSD and/or MRW were the first parameters to change in 8 EG eyes. RPC density changed first in the 9th. At their first points of change, mean ALCSD posteriorly deformed by 100.2 +- 101.2 microns, MRW thinned by 82.3 +- 65.9 microns, RNFLT decreased by 25 +- 14 microns, and RPC density decreased by 4.5 +- 2.1%. RPC density decreased before RNFL thinning in 5 EG eyes. RNFLT decreased before RPC density decreased in 2 EG eyes, while 2 EG eyes had simultaneous changes. Conclusions: In most EG eyes, RPC density decreased before (or simultaneous with) a change in RNFLT, suggesting that vascular factors may play a role in axonal loss in some eyes in early glaucoma.

scholarly journals Astrocyte responses to experimental glaucoma in mouse optic nerve head

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0238104 ◽  
Author(s):  
Sarah Quillen ◽  
Julie Schaub ◽  
Harry Quigley ◽  
Mary Pease ◽  
Arina Korneva ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Experimental Glaucoma

scholarly journals In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180128 ◽  
Author(s):  
Tiago S. Prata ◽  
Flavio S. Lopes ◽  
Vitor G. Prado ◽  
Izabela Almeida ◽  
Igor Matsubara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Depth Imaging ◽  
In Vivo Analysis ◽  
Imaging Optical Coherence Tomography

scholarly journals Static Blood Flow Autoregulation in the Optic Nerve Head in Normal and Experimental Glaucoma

2014 ◽  
Vol 55 (2) ◽  
pp. 873 ◽  
Author(s):  
Lin Wang ◽  
Claude F. Burgoyne ◽  
Grant Cull ◽  
Simon Thompson ◽  
Brad Fortune
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Experimental Glaucoma

scholarly journals Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury

2016 ◽  
Vol 57 (10) ◽  
pp. 4403 ◽  
Author(s):  
Brad Fortune ◽  
Juan Reynaud ◽  
Christy Hardin ◽  
Lin Wang ◽  
Ian A. Sigal ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Axon Injury ◽  
Experimental Glaucoma ◽  
Tissue Compression
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