scholarly journals Hedgehog Signaling Pathway Regulates the Proliferation and Differentiation of Rat Meibomian Gland Epithelial Cells

2021 ◽  
Vol 62 (2) ◽  
pp. 33
Author(s):  
Jing-Yu Qu ◽  
Yu-Ting Xiao ◽  
Ying-Ying Zhang ◽  
Hua-Tao Xie ◽  
Ming-Chang Zhang
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Meibomian Gland ◽  
Hedgehog Signaling Pathway ◽  
Proliferation And Differentiation

scholarly journals Targeted Expression of GLI1 in the Mammary Gland Disrupts Pregnancy-induced Maturation and Causes Lactation Failure

2007 ◽  
Vol 282 (49) ◽  
pp. 36090-36101 ◽  
Author(s):  
Marie Fiaschi ◽  
Björn Rozell ◽  
Åsa Bergström ◽  
Rune Toftgård ◽  
Marika I. Kleman
Keyword(s):  
Mammary Gland ◽  
Epithelial Cells ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Hedgehog Signaling Pathway ◽  
Milk Protein Gene ◽  
Milk Protein Gene Expression ◽  
And Function

The Hedgehog signaling pathway regulates the development and function of numerous tissues and when mis-regulated causes tumorigenesis. To assess the role of a deregulated Hedgehog signaling pathway in the mammary gland we targeted the expression of the Hedgehog effector protein, GLI1, to mammary epithelial cells using a bigenic inducible system. A constitutively active Hedgehog signaling pathway resulted with 100% penetrance in an undifferentiated mammary lobuloalveolar network during pregnancy. GLI1-expressing transgenic females were unable to lactate and milk protein gene expression was essentially absent. The inability to lactate was permanent and independent of continued GLI1 transgene expression. An increased expression of the GLI1 response gene Snail coupled to reduced expression of E-cadherin and STAT5 in the transgenic mammary gland provides a likely molecular explanation, underlying the observed phenotypic changes. In addition, remodeling of the mammary gland after parturition was impaired and expression of GLI1 was associated with accumulation of cellular debris in the mammary ducts during involution, indicating a defect in the clearance of dead cells. Areas with highly proliferative epithelial cells were observed in mammary glands with induced expression of GLI1. Within such areas an increased frequency of cells expressing nuclear Cyclin D1 was observed. Taken together the data support the notion that correct regulation of Hedgehog signaling within the epithelial cell compartment is critical for pregnancy-induced mammary gland development and remodeling.

Relationship between lipid metabolism and Hedgehog signaling pathway

2021 ◽  
Vol 209 ◽  
pp. 105825
Author(s):  
Yuan Gu ◽  
Xiaochen Liu ◽  
Lele Liao ◽  
Yongquan Gao ◽  
Yu Shi ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway

scholarly journals The Role of Sonic Hedgehog-Gli2 Pathway in the Masculinization of External Genitalia

Endocrinology ◽  
2011 ◽  
Vol 152 (7) ◽  
pp. 2894-2903 ◽  
Author(s):  
Shinichi Miyagawa ◽  
Daisuke Matsumaru ◽  
Aki Murashima ◽  
Akiko Omori ◽  
Yoshihiko Satoh ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
External Genitalia ◽  
Sexually Dimorphic ◽  
Hedgehog Signaling Pathway ◽  
Initial Development ◽  
Urethral Plate ◽  
Male External Genitalia

During embryogenesis, sexually dimorphic organogenesis is achieved by hormones produced in the gonad. The external genitalia develop from a single primordium, the genital tubercle, and their masculinization processes depend on the androgen signaling. In addition to such hormonal signaling, the involvement of nongonadal and locally produced masculinization factors has been unclear. To elucidate the mechanisms of the sexually dimorphic development of the external genitalia, series of conditional mutant mouse analyses were performed using several mutant alleles, particularly focusing on the role of hedgehog signaling pathway in this manuscript. We demonstrate that hedgehog pathway is indispensable for the establishment of male external genitalia characteristics. Sonic hedgehog is expressed in the urethral plate epithelium, and its signal is mediated through glioblastoma 2 (Gli2) in the mesenchyme. The expression level of the sexually dimorphic genes is decreased in the glioblastoma 2 mutant embryos, suggesting that hedgehog signal is likely to facilitate the masculinization processes by affecting the androgen responsiveness. In addition, a conditional mutation of Sonic hedgehog at the sexual differentiation stage leads to abnormal male external genitalia development. The current study identified hedgehog signaling pathway as a key factor not only for initial development but also for sexually dimorphic development of the external genitalia in coordination with androgen signaling.

Participation of Polycomb group gene extra sex combs in hedgehog signaling pathway

2004 ◽  
Vol 323 (2) ◽  
pp. 523-533 ◽  
Author(s):  
Norihisa Shindo ◽  
Atsushi Sakai ◽  
Kouji Yamada ◽  
Toru Higashinakagawa
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Polycomb Group ◽  
Hedgehog Signaling Pathway ◽  
Sex Combs ◽  
Polycomb Group Gene
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