scholarly journals Comparative Topographical Analysis of Choroidal Microvascular Dropout Between Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy

2021 ◽  
Vol 62 (13) ◽  
pp. 27
Author(s):  
Eun Jung Lee ◽  
Hyun Joo Kee ◽  
Kyung-Ah Park ◽  
Jong Chul Han ◽  
Changwon Kee
Keyword(s):  
Optic Neuropathy ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Topographical Analysis

Blood rheology in acute anterior ischemic optic neuropathy

1991 ◽  
Vol 11 (6) ◽  
pp. 623-634 ◽  
Author(s):  
B. Bertram ◽  
A. Hoberg ◽  
O. Arend ◽  
S. Wolf ◽  
F. Jung ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Blood Rheology ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy

scholarly journals Protective Effects of Oroxylin A on Retinal Ganglion Cells in Experimental Model of Anterior Ischemic Optic Neuropathy

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 902
Author(s):  
Jia-Ying Chien ◽  
Shu-Fang Lin ◽  
Yu-Yau Chou ◽  
Chi-Ying F. Huang ◽  
Shun-Ping Huang
Keyword(s):  
Retinal Ganglion Cells ◽  
Optic Neuropathy ◽  
Ganglion Cells ◽  
Ischemic Injury ◽  
Anterior Ischemic Optic Neuropathy ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Ischemic Optic Neuropathy ◽  
Retinal Ganglion ◽  
Oroxylin A

Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute vision loss in older people, and there is no effective therapy. The effect of the systemic or local application of steroids for NAION patients remains controversial. Oroxylin A (OA) (5,7-dihydroxy-6-methoxyflavone) is a bioactive flavonoid extracted from Scutellariae baicalensis Georgi. with various beneficial effects, including anti-inflammatory and neuroprotective effects. A previous study showed that OA promotes retinal ganglion cell (RGC) survival after optic nerve (ON) crush injury. The purpose of this research was to further explore the potential actions of OA in ischemic injury in an experimental anterior ischemic optic neuropathy (rAION) rat model induced by photothrombosis. Our results show that OA efficiently attenuated ischemic injury in rats by reducing optic disc edema, the apoptotic death of retinal ganglion cells, and the infiltration of inflammatory cells. Moreover, OA significantly ameliorated the pathologic changes of demyelination, modulated microglial polarization, and preserved visual function after rAION induction. OA activated nuclear factor E2 related factor (Nrf2) signaling and its downstream antioxidant enzymes NAD(P)H:quinone oxidoreductase (NQO-1) and heme oxygenase 1 (HO-1) in the retina. We demonstrated that OA activates Nrf2 signaling, protecting retinal ganglion cells from ischemic injury, in the rAION model and could potentially be used as a therapeutic approach in ischemic optic neuropathy.

Tonic pupil, anterior ischemic optic neuropathy in a teenager with Takayasu arteritis

2013 ◽  
Vol 48 (6) ◽  
pp. e159-e163 ◽  
Author(s):  
Jyoti Matalia ◽  
Nirupama Kasturi ◽  
Hemant D. Anaspure ◽  
Bhujang K. Shetty
Keyword(s):  
Optic Neuropathy ◽  
Takayasu Arteritis ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Tonic Pupil

Suspected Simultaneous Bilateral Anterior Ischemic Optic Neuropathy in a Patient with Behçet's Disease

2005 ◽  
Vol 13 (4) ◽  
pp. 317-325 ◽  
Author(s):  
Yasuyuki Yamauchi ◽  
Jose M.C. Cruz ◽  
Henry J. Kaplan ◽  
Hiroshi Goto ◽  
Jun-ichi Sakai ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Optic Neuropathy ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Behcet's Disease

scholarly journals Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Marion Bienert ◽  
Niklas Plange ◽  
Andreas Remky ◽  
Kay Oliver Arend ◽  
David Kuerten
Keyword(s):  
Blood Flow ◽  
Hydroxyethyl Starch ◽  
Optic Neuropathy ◽  
Acute Effect ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Hypervolemic Hemodilution ◽  
Blood Flow Velocities ◽  
Retrobulbar Hemodynamics ◽  
Flow Velocities

Purpose.Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).Methods.24 patients with acute NAION were included. Retrobulbar hemodynamics were measured using color Doppler imaging before and 15 min after intravenous infusion of 250 cc 10% hydroxyethyl starch (HES). Peak systolic velocity (PSV), end diastolic velocity (EDV), and Pourcelot’s resistive index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs).Results.After infusion of HES blood flow velocities significantly increased in the CRA (PSV from7.53±2.33to8.32±2.51  (p<0.001); EDV from2.16±0.56to2.34±0.55  (p<0.05)) and in the PCAs (PSV from7.18±1.62to7.56±1.55  (p<0.01); EDV from2.48±0.55to2.66±0.6 cm/sec (p<0.01)). The RI of all retrobulbar vessels remained unaffected. Blood pressure and heart rate remained unchanged.Conclusions.Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients. Increased blood flow in the arteries supplying the optic nerve head may lead to a better perfusion in NAION patients. This trial is registered withDRKS00012603.

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