scholarly journals The Relationship Between Macula Retinal Ganglion Cell Density and Visual Function in the Nonhuman Primate

2021 ◽  
Vol 62 (1) ◽  
pp. 5
Author(s):  
Kwame Antwi-Boasiako ◽  
Louvenia Carter-Dawson ◽  
Ronald Harwerth ◽  
Margaret Gondo ◽  
Nimesh Patel
Keyword(s):  
Ganglion Cell ◽  
Cell Density ◽  
Retinal Ganglion Cell ◽  
Nonhuman Primate ◽  
Visual Function ◽  
Retinal Ganglion ◽  
The Relationship

scholarly journals Nerve Fiber Layer Thinning Lags Retinal Ganglion Cell Density Following Crush Axonopathy

2014 ◽  
Vol 55 (10) ◽  
pp. 6505 ◽  
Author(s):  
Gustavo C. Munguba ◽  
Sanja Galeb ◽  
Yuan Liu ◽  
David C. Landy ◽  
Daisy Lam ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Cell Density ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer

Retinal ganglion cell layer and visual function in a patient with optic disc drusen

1998 ◽  
Vol 236 (12) ◽  
pp. 904-915 ◽  
Author(s):  
M.-M. Gellrich ◽  
Stephan Neumaier ◽  
Claudia Auw-Hädrich ◽  
Nils-Claudius Gellrich ◽  
Lutz Lothar Hansen
Keyword(s):  
Ganglion Cell ◽  
Optic Disc ◽  
Retinal Ganglion Cell ◽  
Visual Function ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Ganglion ◽  
Optic Disc Drusen ◽  
Retinal Ganglion Cell Layer

scholarly journals Effect of Ubiquinol on Glaucomatous Neurodegeneration and Oxidative Stress: Studies for Retinal Ganglion Cell Survival and/or Visual Function

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 952
Author(s):  
Genea Edwards ◽  
Yonghoon Lee ◽  
Martha Kim ◽  
Soham Bhanvadia ◽  
Keun-Young Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Visual Function ◽  
Therapeutic Potential ◽  
Control Diet ◽  
Retinal Ganglion ◽  
Complex Ii ◽  
Oxphos Complex ◽  
And Oxidative Stress

Oxidative stress is one of major causal factors in glaucomatous neurodegeneration. Ubiquinol promotes retinal ganglion cell (RGC) survival against glaucomatous insults such as oxidative stress. Here we investigated the effect of ubiquinol on RGC survival and/or visual function in mouse models of glaucoma and oxidative stress. DBA/2J and age-matched DBA/2J-Gpnmb+ (D2-Gpnmb+), which do not develop intraocular pressure elevation, or C57BL/6J mice were fed with ubiquinol (1%) or control diet daily for 5 or 2 months. We assessed RGC survival by Brn3a immunohistochemistry and measured expression levels of active and total BAX, peroxisome proliferator-activated receptor-gamma coactivator 1α, transcription factor A (TFAM) and oxidative phosphorylation (OXPHOS) complex protein. Following induction of oxidative stress by paraquat injection, we also assessed visual function. In glaucomatous retina, ubiquinol supplementation significantly promoted RGC survival, blocked BAX activation and increased TFAM and OXPHOS complex II protein expression. Also, ubiquinol supplementation ameliorated oxidative stress-induced visual dysfunction. These findings indicate that ubiquinol promotes RGC survival by increasing TFAM expression and OXPHOS complex II activity in glaucomatous neurodegeneration, and that ubiquinol enhances RGC survival and preserves visual function against oxidative stress. We propose that ubiquinol has a therapeutic potential for treating oxidative stress-associated glaucomatous neurodegeneration.

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