A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Guorong Li; Astrid F. Nottebaum; Mitchell Brigell; Iris D. Navarro; Ute Ipe; Sarthak Mishra; Maria Gomez-Caraballo; Heather Schmitt; Brandi Soldo; Steve Pakola; Barbara Withers; Kevin G. Peters; Dietmar Vestweber; W. Daniel Stamer

doi:10.1167/iovs.61.14.12

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.61.14.12 ◽

2020 ◽

Vol 61 (14) ◽

pp. 12

Author(s):

Guorong Li ◽

Astrid F. Nottebaum ◽

Mitchell Brigell ◽

Iris D. Navarro ◽

Ute Ipe ◽

...

Keyword(s):

Intraocular Pressure ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Schlemm’S Canal ◽

Outflow Facility ◽

Schlemm's Canal ◽

Molecule Inhibitor

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Faculty Opinions recommendation of A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.739214573.793581969 ◽

2021 ◽

Author(s):

Andrius Kazlauskas

Keyword(s):

Intraocular Pressure ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Schlemm’S Canal ◽

Outflow Facility ◽

Schlemm's Canal ◽

Molecule Inhibitor

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Acute Effects of Intraocular Pressure-Induced Changes in Schlemm's Canal Morphology on Outflow Facility in Healthy Human Eyes

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.61.8.36 ◽

2020 ◽

Vol 61 (8) ◽

pp. 36

Author(s):

Wei Chen ◽

Tian Hu ◽

Qiongfang Xu ◽

Zhiqi Chen ◽

Hong Zhang ◽

...

Keyword(s):

Intraocular Pressure ◽

Acute Effects ◽

Schlemm’S Canal ◽

Healthy Human ◽

Outflow Facility ◽

Schlemm's Canal ◽

Induced Changes ◽

Human Eyes ◽

Canal Morphology

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Faculty Opinions recommendation of Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021658.247635 ◽

2004 ◽

Author(s):

William Kaelin

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Shh Pathway ◽

Molecule Inhibitor

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Faculty Opinions recommendation of Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1025625.322882 ◽

2005 ◽

Author(s):

James Stivers

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Atm Kinase ◽

Molecule Inhibitor ◽

Hiv 1

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Faculty Opinions recommendation of Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1033159.375732 ◽

2006 ◽

Author(s):

Berl R Oakley

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor

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Faculty Opinions recommendation of The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066069.520680 ◽

2007 ◽

Author(s):

Nathanael Gray

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Bi 2536

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Faculty Opinions recommendation of The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066069.519039 ◽

2007 ◽

Author(s):

Tarun Kapoor

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Bi 2536

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Faculty Opinions recommendation of Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1283961.751061 ◽

2009 ◽

Author(s):

Marie-France Carlier

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitor ◽

Actin Assembly ◽

Molecule Inhibitor ◽

Identification And Characterization

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Faculty Opinions recommendation of Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5059957.4994055 ◽

2010 ◽

Author(s):

Michael Weber ◽

Daniel G Gioeli

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Amino Terminus ◽

Recurrent Prostate Cancer ◽

Molecule Inhibitor

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Faculty Opinions recommendation of A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717957380.793461863 ◽

2012 ◽

Author(s):

Pengbo Zhou ◽

Jeffrey Hannah

Keyword(s):

Multiple Myeloma ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Myeloma Cells ◽

Molecule Inhibitor ◽

Specific Protease ◽

Ubiquitin Specific Protease

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