scholarly journals Characterization of Retinal Microvascular Complications and the Effects of Endoplasmic Reticulum Stress in Mouse Models of Diabetic Atherosclerosis

2020 ◽  
Vol 61 (10) ◽  
pp. 49
Author(s):  
Vienna Mazzoli ◽  
Lexy H. Zhong ◽  
Vi T. Dang ◽  
Yuanyuan Shi ◽  
Geoff H. Werstuck
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mouse Models ◽  
Microvascular Complications

scholarly journals Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis

eNeuro ◽  
2017 ◽  
Vol 4 (4) ◽  
pp. ENEURO.0025-17.2017 ◽  
Author(s):  
Denise Isabelle Briggs ◽  
Erwin Defensor ◽  
Pooneh Memar Ardestani ◽  
Bitna Yi ◽  
Michelle Halpain ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Learning And Memory ◽  
Mouse Models ◽  
Memory Impairment

scholarly journals Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigmversusknockin paradigm

2018 ◽  
Vol 293 (9) ◽  
pp. 3118-3125 ◽  
Author(s):  
Shoko Hashimoto ◽  
Ayano Ishii ◽  
Naoko Kamano ◽  
Naoto Watamura ◽  
Takashi Saito ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mouse Models ◽  
Stress Responses

scholarly journals Isolation and Characterization of a Putative Transducer of Endoplasmic Reticulum Stress in Oryza sativa

2002 ◽  
Vol 43 (5) ◽  
pp. 532-539 ◽  
Author(s):  
Yoko Okushima ◽  
Nozomu Koizumi ◽  
Yube Yamaguchi ◽  
Yukio Kimata ◽  
Kenji Kohno ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Oryza Sativa ◽  
Endoplasmic Reticulum Stress ◽  
Isolation And Characterization

scholarly journals Transcriptomic characterization of short duration endoplasmic reticulum stress on cultured human proximal tubule cells

2014 ◽  
Vol 15 (Suppl 10) ◽  
pp. P5 ◽  
Author(s):  
Yan Zhang ◽  
Michelle Barati ◽  
Ignacio Munoz ◽  
Ming Li ◽  
Danny Wilkey ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Proximal Tubule ◽  
Short Duration ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule

scholarly journals Functional Characterization of Arabidopsis Calreticulin1a: A Key Alleviator of Endoplasmic Reticulum Stress

2008 ◽  
Vol 49 (6) ◽  
pp. 912-924 ◽  
Author(s):  
A. Christensen ◽  
K. Svensson ◽  
S. Persson ◽  
J. Jung ◽  
M. Michalak ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Functional Characterization

scholarly journals Characterization of GIV‐GRP78 Interaction During Endoplasmic Reticulum Stress

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Clariss Limso ◽  
Jordan Ngo ◽  
Peter Nguyen ◽  
Deepali Bhandari
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress

scholarly journals Proteomic Characterization of Spontaneous Stress-Induced In Vitro Apoptosis of Human Acute Myeloid Leukemia Cells; Focus on Patient Heterogeneity and Endoplasmic Reticulum Stress

Hemato ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 607-627
Author(s):  
Elise Aasebø ◽  
Annette K. Brenner ◽  
Maria Hernandez-Valladares ◽  
Even Birkeland ◽  
Håkon Reikvam ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Acute Myeloid Leukemia ◽  
Stress Response ◽  
Endoplasmic Reticulum Stress ◽  
Myeloid Leukemia ◽  
Unfolded Protein ◽  
Human Acute Myeloid Leukemia ◽  
Acute Myeloid

In vitro culture is widely used for characterization of primary human acute myeloid leukemia (AML) cells, but even when using optimized handling and culture conditions the AML cells show spontaneous in vitro apoptosis with a gradual decrease in cell viability during culture. The extent of this stress-induced apoptosis varies between patients, and a high degree of apoptosis is associated with high pre-culture BCL2 levels together with low levels of BAX and Heat Shock Proteins 30 and 90. We compared the global proteomic profiles during ongoing in vitro apoptosis for patients with high and low AML cell viability (i.e., less extensive versus extensive spontaneous apoptosis) after 48 h of culture. We identified 7902 proteins, but only 276 proteins differed significantly between patients with high (i.e., >25% viable cells; 192 upregulated and 84 downregulated peptides) and low viability after in vitro culture. Protein interaction network analysis based on these 276 protein identified three protein networks that included 18 proteins; most of these proteins were localized to the endoplasmic reticulum and several of them are involved in or are altered during the process of endoplasmic reticulum stress/unfolded protein stress response. To conclude, primary AML cells are heterogeneous with regard to degree of apoptosis in response to cellular stress, and this difference in regulation of apoptosis is associated with differences in the induction of and/or response to the unfolded protein stress response.

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