scholarly journals Paradoxical Changes Underscore Epigenetic Reprogramming During Adult Zebrafish Extraocular Muscle Regeneration

2019 ◽  
Vol 60 (15) ◽  
pp. 4991 ◽  
Author(s):  
Christina F. Tingle ◽  
Brian Magnuson ◽  
Yi Zhao ◽  
Curtis J. Heisel ◽  
Phillip E. Kish ◽  
...  
Keyword(s):  
Muscle Regeneration ◽  
Extraocular Muscle ◽  
Epigenetic Reprogramming ◽  
Adult Zebrafish

scholarly journals Twist3 is required for dedifferentiation during extraocular muscle regeneration in adult zebrafish

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231963
Author(s):  
Yi Zhao ◽  
Ke’ale W. Louie ◽  
Christina F. Tingle ◽  
Cuilee Sha ◽  
Curtis J. Heisel ◽  
...  
Keyword(s):  
Muscle Regeneration ◽  
Extraocular Muscle ◽  
Adult Zebrafish

scholarly journals Myocyte Dedifferentiation Drives Extraocular Muscle Regeneration in Adult Zebrafish

2015 ◽  
Vol 56 (8) ◽  
pp. 4977 ◽  
Author(s):  
Alfonso Saera-Vila ◽  
Daniel S. Kasprick ◽  
Tyler L. Junttila ◽  
Steven J. Grzegorski ◽  
Ke'ale W. Louie ◽  
...  
Keyword(s):  
Muscle Regeneration ◽  
Extraocular Muscle ◽  
Adult Zebrafish

scholarly journals Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192214 ◽  
Author(s):  
Alfonso Saera-Vila ◽  
Ke’ale W. Louie ◽  
Cuilee Sha ◽  
Ryan M. Kelly ◽  
Phillip E. Kish ◽  
...  
Keyword(s):  
Growth Factors ◽  
Muscle Regeneration ◽  
Extraocular Muscle ◽  
Insulin Like Growth Factors

scholarly journals Fgf regulates dedifferentiation during skeletal muscle regeneration in adult zebrafish

2016 ◽  
Vol 28 (9) ◽  
pp. 1196-1204 ◽  
Author(s):  
Alfonso Saera-Vila ◽  
Phillip E. Kish ◽  
Alon Kahana
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Adult Zebrafish

Extraocular Muscle Regeneration in Primates

Ophthalmology ◽  
1992 ◽  
Vol 99 (4) ◽  
pp. 582-589 ◽  
Author(s):  
Bruce M. Carlson ◽  
Stephen Emerick ◽  
Thomas E. Komorowski ◽  
Edgar A. Rainin ◽  
Beverly M. Shepard
Keyword(s):  
Muscle Regeneration ◽  
Extraocular Muscle

Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish

Science ◽  
2021 ◽  
Vol 372 (6538) ◽  
pp. 201-205
Author(s):  
Masahito Ogawa ◽  
Fan-Suo Geng ◽  
David T. Humphreys ◽  
Esther Kristianto ◽  
Delicia Z. Sheng ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heart Development ◽  
Transcriptional Regulator ◽  
Cardiac Regeneration ◽  
Epigenetic Reprogramming ◽  
Mitochondrial Metabolism ◽  
Adult Zebrafish ◽  
Transcription Factor Network ◽  
Oxidative Respiration

Cardiac regeneration requires dedifferentiation and proliferation of mature cardiomyocytes, but the mechanisms underlying this plasticity remain unclear. Here, we identify a potent cardiomyogenic role for Krüppel-like factor 1 (Klf1/Eklf), which is induced in adult zebrafish myocardium upon injury. Myocardial inhibition of Klf1 function does not affect heart development, but it severely impairs regeneration. Transient Klf1 activation is sufficient to expand mature myocardium in uninjured hearts. Klf1 directs epigenetic reprogramming of the cardiac transcription factor network, permitting coordinated cardiomyocyte dedifferentiation and proliferation. Myocardial expansion is supported by Klf1-induced rewiring of mitochondrial metabolism from oxidative respiration to anabolic pathways. Our findings establish Klf1 as a core transcriptional regulator of cardiomyocyte renewal in adult zebrafish hearts.

Fine structure of early degenerating myofibers in the tibialis anterior of young ‘MDX’ mouse

1988 ◽  
Vol 46 ◽  
pp. 322-323
Author(s):  
H.D. Geissinger ◽  
C.K. McDonald-Taylor
Keyword(s):  
Fine Structure ◽  
Muscle Regeneration ◽  
Tibialis Anterior ◽  
Genetic Defect ◽  
Mdx Mouse ◽  
Mdx Mice ◽  
Histopathological Changes ◽  
Electron Microscopic ◽  
Dystrophic Mouse ◽  
Preliminary Study

A new strain of mice, which had arisen by mutation from a dystrophic mouse colony was designated ‘mdx’, because the genetic defect, which manifests itself in brief periods of muscle destruction followed by episodes of muscle regeneration appears to be X-linked. Further studies of histopathological changes in muscle from ‘mdx’ mice at the light microscopic or electron microscopic levels have been published, but only one preliminary study has been on the tibialis anterior (TA) of ‘mdx’ mice less than four weeks old. Lesions in the ‘mdx’ mice vary between different muscles, and centronucleation of fibers in all muscles studied so far appears to be especially prominent in older mice. Lesions in young ‘mdx’ mice have not been studied extensively, and the results appear to be at variance with one another. The degenerative and regenerative aspects of the lesions in the TA of 23 to 26-day-old ‘mdx’ mice appear to vary quantitatively.

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