scholarly journals Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma

2019 ◽  
Vol 60 (8) ◽  
pp. 3110 ◽  
Author(s):  
Stuart K. Gardiner ◽  
Grant Cull ◽  
Brad Fortune ◽  
Lin Wang
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Open Angle ◽  
Early Primary

scholarly journals Resting nailfold capillary blood flow in primary open-angle glaucoma

2018 ◽  
Vol 103 (2) ◽  
pp. 203-207 ◽  
Author(s):  
Clara C Cousins ◽  
Jonathan C Chou ◽  
Scott H Greenstein ◽  
Stacey C Brauner ◽  
Lucy Q Shen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Beta Blocker ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Vessel Diameter ◽  
Ocular Blood Flow ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Open Angle

Background/AimsAn altered haemodynamic profile for various ocular posterior segment capillary beds has been documented in primary open-angle glaucoma (POAG). POAG may also involve abnormal non-ocular blood flow, and the nailfold capillaries, which are not affected by elevated intraocular pressure (IOP), are readily assessable.MethodsWe measured resting nailfold capillary blood flow in 67 POAG and 63 control subjects using video capillaroscopy. Masked readers tracked blood column voids between consecutive, registered image sequence frames, measured vessel diameter and calculated blood flow. We used multiple logistic regression to investigate the relation between nailfold capillary blood flow and POAG. In secondary analyses, we stratified cases by maximum IOP and concurrent topical beta-blocker use.ResultsMean (±SD) blood flow in picolitres per second was 26.8±17.6 for POAG cases and 50.1±24.2 for controls (p<0.0001). After adjustment for demographic and clinical factors including blood pressure and pulse, every picolitre per second increase in resting nailfold blood flow was associated with a 6% (95% CI 0.92 to 0.96) reduced odds of POAG (p<0.0001). Similar relations between nailfold capillary blood flow and POAG were found for cases stratified by maximum known IOP and for cases stratified by concurrent topical beta-blocker use.ConclusionReduced resting nailfold capillary blood flow is present in POAG independent of covariates such as blood pressure, pulse and IOP.

scholarly journals Optic nerve head blood flow regulation during changes in arterial blood pressure in patients with primary open-angle glaucoma

2018 ◽  
Vol 97 (1) ◽  
pp. e36-e41 ◽  
Author(s):  
Ahmed M. Bata ◽  
Klemens Fondi ◽  
Katarzyna J. Witkowska ◽  
René M. Werkmeister ◽  
Anton Hommer ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Optic Nerve ◽  
Arterial Blood Pressure ◽  
Optic Nerve Head ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Flow Regulation ◽  
Open Angle ◽  
Arterial Blood

scholarly journals The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Primary Open-Angle Glaucoma Patients

2017 ◽  
Vol 58 (7) ◽  
pp. 3181 ◽  
Author(s):  
Naoki Kiyota ◽  
Yukihiro Shiga ◽  
Shiori Suzuki ◽  
Marika Sato ◽  
Naoko Takada ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle
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