scholarly journals Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population

2018 ◽  
Vol 59 (13) ◽  
pp. 5542 ◽  
Author(s):  
Akiko Miki ◽  
Yoichi Sakurada ◽  
Koji Tanaka ◽  
Kentaro Semba ◽  
Yoshinori Mitamura ◽  
...  
Keyword(s):  
Association Study ◽  
Central Serous Chorioretinopathy ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide

scholarly journals A Genome-Wide Association Study Identifies a Novel Susceptibility Locus at The DLGAP1 Gene For Resistant Hypertension in The Japanese Population

2021 ◽  
Author(s):  
Yasuo Takahashi ◽  
Keiko Yamazaki ◽  
Yoichiro Kamatani ◽  
Michiaki Kubo ◽  
Koichi Matsuda ◽  
...  
Keyword(s):  
Association Study ◽  
Resistant Hypertension ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Neuron Development ◽  
Asian Populations ◽  
Genome Wide ◽  
A Genome

Abstract Numerous genetic variants associated with hypertension and blood pressure are known, but there is a paucity of evidence from genetic studies of resistant hypertension, especially in the Asian populations. To identify novel genetic loci associated with resistant hypertension in the Japanese population, we conducted a genome-wide association study with 2,705 resistant hypertension cases and 21,296 mild hypertension controls, all from BioBank Japan. We identified one novel susceptibility locus, rs1442386 on chromosome 18p11.3 (DLGAP1), achieving genome-wide significance (odds ratio (95% CI) = 0.85 (0.81–0.90), P = 3.75 × 10−8) and 17 loci showing suggestive association, including rs62525059 of 8q24.3 (CYP11B2). We further detected biological processes associated with resistant hypertension, including chemical synaptic transmission, regulation of transmembrane transport, neuron development and neurological system processes, highlighting the importance of the nervous system. This study provides insights into the etiology of resistant hypertension in the Japanese population.

scholarly journals Replication of a genome-wide association study of panic disorder in a Japanese population

2009 ◽  
Vol 55 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Takeshi Otowa ◽  
Hisashi Tanii ◽  
Nagisa Sugaya ◽  
Eiji Yoshida ◽  
Ken Inoue ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Association Study ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

2020 ◽  
Vol 52 (7) ◽  
pp. 669-679 ◽  
Author(s):  
Kazuyoshi Ishigaki ◽  
Masato Akiyama ◽  
Masahiro Kanai ◽  
Atsushi Takahashi ◽  
Eiryo Kawakami ◽  
...  
Keyword(s):  
Association Study ◽  
Japanese Population ◽  
Large Scale ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide

scholarly journals A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25

2010 ◽  
Vol 42 (10) ◽  
pp. 902-905 ◽  
Author(s):  
Pirro G Hysi ◽  
Terri L Young ◽  
David A Mackey ◽  
Toby Andrew ◽  
Alberto Fernández-Medarde ◽  
...  
Keyword(s):  
Association Study ◽  
Refractive Error ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-Wide Association Study of Bladder Cancer in a Chinese Cohort Reveals a New Susceptibility Locus at 5q12.3

2016 ◽  
Vol 76 (11) ◽  
pp. 3277-3284 ◽  
Author(s):  
Meilin Wang ◽  
Zhiqiang Li ◽  
Haiyan Chu ◽  
Qiang Lv ◽  
Dingwei Ye ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide ◽  
Chinese Cohort
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