scholarly journals Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma

2019 ◽  
Vol 60 (4) ◽  
pp. 889 ◽  
Author(s):  
Shonraj Ballae Ganeshrao ◽  
Sirisha Senthil ◽  
Nikhil Choudhari ◽  
Shravya Sri Durgam ◽  
Chandra Sekhar Garudadri
Keyword(s):  
Visual Field ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Visual Field Progression ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
High Tension

scholarly journals Intraocular asymmetry of visual field defects in primary angle-closure glaucoma, high-tension glaucoma, and normal-tension glaucoma in a Chinese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junhong Jiang ◽  
Cong Ye ◽  
Cong Zhang ◽  
Wenqing Ye ◽  
Xiaoyan Wang ◽  
...  
Keyword(s):  
Visual Field ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
High Tension ◽  
Significant Difference ◽  
The Mean ◽  
Severity Levels

AbstractDirect comparison data on spatial patterns of visual field (VF) defects among primary angle-closure glaucoma (PACG), high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) are not available. We aimed to compare the intraocular asymmetry of VF loss among patients with PACG, NTG and HTG across different severity levels. A total of 162 eyes of 114 patients with PACG, 111 eyes of 74 patients with HTG and 148 eyes of 102 patients with NTG were included. VF defects were categorized into 3 stages (early, moderate, and advanced), and each hemifield was divided into 5 regions according to the Glaucoma hemifield test (GHT). The mean total deviation (TD) of each GHT region was calculated. In the early stage, the paracentral, peripheral arcuate 1 and peripheral arcuate 2 regions in the superior hemifield in the NTG group had significantly worse mean TDs than their corresponding regions in the inferior hemifield. In the advanced stage, the central region in the superior hemifield in the PACG group had a significantly worse mean TD than that in the inferior hemifield. There was no significant difference in the mean TD for any of the five regions between hemifields across all severity levels in the in the HTG group. The superior hemifield was affected more severely than the inferior hemifield in all three subtypes of primary glaucoma. This asymmetric tendency was more pronounced in NTG than in PACG and HTG.

scholarly journals Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ruyue Shen ◽  
Yu Meng Wang ◽  
Carol Y. Cheung ◽  
Poemen P. Chan ◽  
Clement C. Tham
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Disease Severity ◽  
Optical Coherence Tomography Angiography ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Rnfl Thickness

AbstractTo investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369 ± 0.781%) compared with PACG eyes (55.389 ± 0.721%, P = 0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis revealed that, for PACG and NTG eyes, decreased cpVD ([PACG] β = −4.242; CI: −8.120, −0.363 vs [NTG] β = −5.531; CI: −9.472, −1.590) and cpFD ([PACG] β = −8.894;CI: −11.925, −5.864 vs [NTG] β = −12.064; CI: −17.095, −6.932) were associated with decreased RNFL thickness (all P ≤ 0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (P = 0.028). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (β = −0.707; CI: −1.090, −0.324; P ≤ 0.001) and not associated with the visual field parameters in PACG eyes. Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.

scholarly journals Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Shengjie Li ◽  
Mingxi Shao ◽  
Yingzhu Li ◽  
Xiaojuan Li ◽  
Yani Wan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Regression Analysis ◽  
Visual Field ◽  
Serum Levels ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Cox Regression Analysis ◽  
Visual Field Progression ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Purpose. To investigate the serum changes of oxidative stress markers and the relationship between these factors and visual field (VF) progression in patients with primary angle closure glaucoma (PACG). Methods. A case-control and a prospective cohort study. A total of 94 patients with PACG and 89 normal controls were enrolled. Furthermore, 94 PACG subjects were followed up for at least two years (once every six months). All participants were evaluated for serum levels of superoxide dismutase (SOD), total antioxidant status (TAS), hydrogen peroxide (H2O2), malondialdehyde (MDA), glutathione peroxidase, glutathione reductase, and detailed eye and systematic examination. Binary logistic regression analysis and Cox regression analysis were performed. Results. The serum levels of SOD and TAS in the PACG group were significantly lower than those in the control group (p<0.001). Meanwhile, PACG subjects had significantly higher levels of MDA and H2O2 than the normal control subjects (p<0.001). Serum levels of TAS (OR=0.773, 95%CI=0.349−0.714, p<0.001), SOD (OR=0.975, 95%CI=0.955−0.995, p<0.001), MDA (OR=1.155, 95%CI=1.080−1.235, p<0.001), and H2O2 (OR=1.216, 95%CI=1.142−1.295, p<0.001) were independent risk/protective factors for PACG. TAS levels (HR=0.041, 95%CI=0.008–0.218, p<0.001), SOD levels (HR=0.983, 95%CI=0.971–0.994, p=0.003), and MDA levels (HR=1.010, 95%CI=1.001–1.018, p=0.015) at baseline were associated with visual field progression. Kaplan–Meier curves reveal that patients with TAS<0.95/SOD<143/MDA>12 had a significantly higher percentage of PACG progression (p<0.05). Conclusions. Decreased levels of TAS and SOD as well as increased levels of MDA at baseline were associated with VF progression in patients with PACG. These findings suggest that oxidative stress was involved in the onset and development of PACG.

scholarly journals Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Harsha L. Rao ◽  
Thanemozhi Srinivasan ◽  
Zia S. Pradhan ◽  
Shruthi Sreenivasaiah ◽  
Dhanaraj A.S. Rao ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Optical Coherence Tomography Angiography ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Optical Coherence ◽  
Visual Field Progression ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma
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