scholarly journals Antecedents of Soft Drusen, the Specific Deposits of Age-Related Macular Degeneration, in the Biology of Human Macula

2018 ◽  
Vol 59 (4) ◽  
pp. AMD182 ◽  
Author(s):  
Christine A. Curcio
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Soft Drusen

scholarly journals Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Young Ho Kim ◽  
Boram Lee ◽  
Edward Kang ◽  
Jaeryung Oh
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Soft Drusen ◽  
Pachychoroid Neovasculopathy ◽  
The Common ◽  
Common Pathogenesis ◽  
Clustering Pattern ◽  
Normal Controls

AbstractChoroidal changes have been suggested to be involved in the pathophysiology of both age-related macular degeneration (AMD) and pachychoroid spectrum diseases (PSD). To find out the choroidal characteristics of each disease groups, various groups of AMD and PSD were classified into several clusters according to choroidal profiles based on subfoveal choroidal thickness (CT), peripapillary CT, the ratio of subfoveal CT to peripapillary CT and age. We retrospectively analyzed 661 eyes, including 190 normal controls and 471 with AMD or PSDs. In the AMD groups, eyes with soft drusen or reticular pseudodrusen were belonged to the same cluster as those with classic exudative AMD (all p < 0.001). However, eyes with pachydrusen were not clustered with eyes from other AMD groups; instead, they were classified in the same cluster as eyes from the PSD group (all p < 0.001). In the PSD group, eyes with pachychoroid neovasculopathy were grouped in the same cluster of those with polypoidal choroidal vasculopathy (p < 0.001). The cluster analysis based on the CT profiles, including subfoveal CT, peripapillary CT, and their ratio, revealed a clustering pattern of eyes with AMD and PSDs. These findings support the suggestion that pachydrusen has the common pathogenesis as PSD.

Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population

2018 ◽  
Vol 102 (12) ◽  
pp. 1691-1695 ◽  
Author(s):  
Emma Connolly ◽  
Maedbh Rhatigan ◽  
Aisling M O’Halloran ◽  
Katherine Alyson Muldrew ◽  
Usha Chakravarthy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Disease Progression ◽  
Genetic Risk ◽  
Risk Allele ◽  
Genetic Risk Factors ◽  
Age Related Macular Degeneration ◽  
Complement Factor ◽  
Age Related ◽  
Soft Drusen

Background/aimsAge-related macular degeneration (AMD) is estimated to affect 196 million people >50 years old globally. Prevalence of AMD-associated genetic risk factors and rate of disease progression are unknown in Ireland.MethodsPrevalence of AMD-associated genetic risk variants, complement factor H (CFH) rs1061170, age-related maculopathy susceptibility 2 (ARMS2) rs10490924, component 3 (C3) rs2230199, complement factor B (CFB) rs641153 and superkiller viralicidic activity 2-like (SKIV2L) rs429608 and 4-year progression data in a population-representative cohort (The Irish Longitudinal study on Ageing (TILDA)) were assessed. 4473 participants ≥50 years were assessed. 4173 had no disease n=1843; 44% male and n=2330; 56% female, mean age 60±9.0, 300 had AMD n=136; 45% male and n=164; 55% female, mean age 64±9.0. A 4-year follow-up was undertaken with 66% of AMD cases attending. Progression and regression from early to late AMD were measured. Genetic association as indicators of disease and as predictors of progression were assessed by multinomial logistic regression.ResultsOlder age and the presence of CFH and ARMS2 risk alleles are two main risk factors associated with the prevalence of AMD in the TILDA cohort. 23% progressed to a higher grade of AMD. Carriers of CFH risk allele showed a strong association for disease progression. Heterozygosity for ARMS2 risk allele predicted progression to late AMD. 75% of those who progressed from early to late disease had soft drusen and hyperpigmentation at baseline.ConclusionsThe prevalence of risk-associated genes and 4-year progression rates of AMD in this Ireland cohort are comparable with other Caucasian populations. CFH Y402H is associated with disease progression, with soft drusen and hyperpigmentation as high-risk features.

Abundance and multimodal visibility of soft drusen in early age-related macular degeneration

Retina ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ling Chen ◽  
Jeffrey D. Messinger ◽  
Kenneth R. Sloan ◽  
Jessica Wong ◽  
Austin Roorda ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Age Related ◽  
Soft Drusen

scholarly journals Haemorheopheresis could block the progression of the dry form of age-related macular degeneration with soft drusen to the neovascular form

2010 ◽  
Vol 89 (5) ◽  
pp. 463-471 ◽  
Author(s):  
Eva Rencová ◽  
Milan Bláha ◽  
Jan Studnička ◽  
Martin Blažek ◽  
Vladimír Bláha ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Soft Drusen

LASER PHOTOCOAGULATION TO TREAT MACULAR SOFT DRUSEN IN AGE-RELATED MACULAR DEGENERATION

Retina ◽  
1994 ◽  
Vol 14 (5) ◽  
pp. 391-396 ◽  
Author(s):  
MARTA S. FIGUEROA ◽  
ANGEL REGUERAS ◽  
JOSEFINA BERTRAND
Keyword(s):  
Macular Degeneration ◽  
Laser Photocoagulation ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Soft Drusen

scholarly journals Systemic and Genetic Risk Factors for Reticular Macular Disease and Soft Drusen in Age- Related Macular Degeneration

2021 ◽  
Author(s):  
Robert J. Thomson ◽  
Joshua Chazaro ◽  
Oscar Otero-Marquez ◽  
Gerardo Ledesma-Gil ◽  
Yuehong Tong ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Macular Disease ◽  
Risk Genes ◽  
Risk Alleles ◽  
Age Related ◽  
Genetic Risks ◽  
Soft Drusen ◽  
Systemic Associations ◽  
Subretinal Drusenoid Deposits

Purpose: Soft drusen and subretinal drusenoid deposits (SDD) aka reticular macular disease (RMD) characterize two pathways to advanced age-related macular degeneration (AMD). We propose these pathways are distinct diseases, with distinct genetic risks, serum risks and associated systemic diseases. Methods: 126 Subjects with AMD had: retinal imaging for RMD status, serum risks, genetic testing, and histories of cardiovascular disease (CVD) and stroke. Results: 62 subjects had RMD, 64 were nonRMD (drusen only), 51 had CVD or Stroke. RMD correlated significantly with: ARMS2 risk allele (p= 0.019); lower mean serum HDL (61 vs. 69 mg/dl, p= 0.038, t test); CVD and troke (34/51 RMD, p= 0.001). NonRMD correlated/trended with: APOE2 (p= 0.032) and CETP (p= 0.072) risk alleles. 97 subjects total had some drusen, which correlated with CFH risk (p= 0.016). Multivariate independent risks for RMD were: CVD and Stroke (p= 0.008), and ARMS2 homozygous risk (p= 0.038). Conclusion: The RMD and soft drusen AMD pathways have distinct systemic associations, serum and genetic risks. RMD is associated with CVD and stroke, ARMS2 risk, and lower HDL; drusen with CFH risk and two lipid risk genes. These pathways appear to be distinct diseases leading to advanced AMD.

scholarly journals Topographic Distribution and Progression of Soft Drusen Volume in Age-Related Macular Degeneration Implicate Neurobiology of Fovea

2021 ◽  
Vol 62 (2) ◽  
pp. 26
Author(s):  
Andreas Pollreisz ◽  
Gregor S. Reiter ◽  
Hrvoje Bogunovic ◽  
Lukas Baumann ◽  
Astrid Jakob ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Soft Drusen ◽  
Topographic Distribution

scholarly journals Clinical Characteristics of Neovascular Age-Related Macular Degeneration without Typical Drusen

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hiroyuki Kamao ◽  
Katsutoshi Goto ◽  
Kento Matsuno ◽  
Kenichi Mizukawa ◽  
Atsushi Miki ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Clinical Characteristics ◽  
Smoking Status ◽  
Age Related Macular Degeneration ◽  
Patient Recall ◽  
Age Related ◽  
Treatment Naïve ◽  
Soft Drusen ◽  
Number Of Injections ◽  
Subretinal Drusenoid Deposits

Purpose. To evaluate the clinical characteristics of neovascular age-related macular degeneration (nAMD) patients without typical drusen. Methods. We retrospectively studied 165 eyes in 165 patients with treatment-naïve nAMD, including typical AMD and polypoidal choroidal vasculopathy (PCV). According to the fellow eye condition, the patients were divided into nAMD with and without typical drusen groups. Eyes with soft drusen or subretinal drusenoid deposits were classified into the nAMD with the typical drusen group. Smoking status and diagnoses of hypertension and diabetes were identified from hospital records and patient recall. We assessed best-corrected visual acuity (BCVA), central retinal thickness (CRT) at the fovea, subfoveal choroidal thickness (SFCT), and the number of injections received. Results. The nAMD without typical drusen group was significantly younger (77.9 ± 7.6 vs. 71.8 ± 8.3, P < 0.001 ) and had thicker SFCT at baseline (207.9 ± 99.5 vs. 260.1 ± 113.2 μm, P = 0.007 ) and a higher proportion of PCV (30.6 vs. 63.1%, P < 0.001 ). The proportion of ever-smokers was significantly higher in the nAMD without typical drusen group (54.8 vs. 70.9%, P = 0.036 ). There were no statistically significant differences in the proportion of patients with hypertension or diabetes; BCVA, CRT, or SFCT changes; or the number of injections between the nAMD with and without typical drusen groups. Conclusion. The clinical features of patients in the nAMD without typical drusen group were almost identical to those of pachychoroid-driven choroidal neovascularization (CNV) patients. The nAMD without typical drusen group had a significantly higher proportion of ever-smokers than the nAMD with typical drusen group. Smoking could be a risk factor for the development of pachychoroid-driven CNV.

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