scholarly journals Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges

2018 ◽  
Vol 59 (4) ◽  
pp. AMD78 ◽  
Author(s):  
Mandeep S. Singh ◽  
Robert E. MacLaren
Keyword(s):  
Stem Cell ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Stem Cell Treatment

Gene Therapy, Stem Cell Treatment and Retinal Implant in Dry-Form (Non-Neovascular) Age-Related Macular Degeneration

2017 ◽  
pp. 149-154
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Retinal Implant ◽  
Age Related ◽  
Functional Vision ◽  
Stem Cell Treatment ◽  
End Stage ◽  
Legal Blindness

Nowadays there is no treatment option except antioxidant support which decelerates the progression of dry-type age-related macular degeneration (ARMD) which is one of the most common reasons for legal blindness in elderly people. Promising outcomes have been obtained with stem cell treatment and gene therapy in dry-type ARMD in the recent studies which are done in the light of the advanced bioengineering developments. In addition, very rapid advances have been developing related to the retinal prosthesis implantation which is performed to regain their functional vision in end-stage ARMD patients.

Human Pluripotent Stem Cell Strategies for Age-Related Macular Degeneration

2014 ◽  
Vol 91 (8) ◽  
pp. 887-893 ◽  
Author(s):  
Kathryn C. Davidson ◽  
Robyn H. Guymer ◽  
Martin F. Pera ◽  
Alice Pébay
Keyword(s):  
Stem Cell ◽  
Macular Degeneration ◽  
Pluripotent Stem Cell ◽  
Age Related Macular Degeneration ◽  
Human Pluripotent Stem Cell ◽  
Age Related

Stem Cell Therapy for the Treatment of Dry Age-Related Macular Degeneration

2015 ◽  
Vol 3 (1) ◽  
pp. 16-25
Author(s):  
Lisa C. Olmos ◽  
Hossein Nazari ◽  
Damien C. Rodger ◽  
Mark S. Humayun
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Macular Degeneration ◽  
Stem Cell Therapy ◽  
Age Related Macular Degeneration ◽  
Age Related

Multimodal Physiological Medicine and Macular Degeneration

2010 ◽  
Vol 04 (01) ◽  
pp. 101
Author(s):  
George W Rozakis ◽  
Sergey A Dzugan ◽  
◽  
Keyword(s):  
Stem Cell ◽  
Macular Degeneration ◽  
Retinal Pigment Epithelial ◽  
Cell Function ◽  
Retinal Pigment Epithelial Cell ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial ◽  
Age Related ◽  
Steroidal Hormones

Multimodal physiological medicine is the art of restoring physiology to youthful levels for the purpose of preventing and treating age-related diseases. Age-related macular degeneration (AMD) is presented as a disease that is caused by multiple errors of physiology including deficiencies of the steroidal hormones dehydroepiandrosterone (DHEA), pregnenolone, oestriol, oestradiol, oestrone, testosterone and progesterone as well as deficiencies in melatonin, zinc and other nutrients. It is proposed that multiple steroidal deficiency results in a compensatory attempt to synthesise hormones from cholesterol in the macula and that this conversion is dysfunctional in AMD, resulting in cholesterol-laden drusen. Furthermore, it is suggested that physiological errors indirectly lead to retinal pigment epithelial cell failure due to a decline in stem cell function. It is suggested that macular degeneration can be safely and more efficaciously treated with combinations of hormones, nutrients and vitamins and that such treatment strikes at the underlying cause(s) of the disease and may reduce associated cardiovascular risk.

Increased levels of circulating CD34+ cells in neovascular age-related macular degeneration: relation with clinical and OCT features

2018 ◽  
Vol 28 (1) ◽  
pp. 80-86
Author(s):  
Caner Kara ◽  
Pınar Ç. Özdal ◽  
Emrullah Beyazyıldız ◽  
Nurgül E. Özcan ◽  
Mehmet Y. Teke ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
Age Related ◽  
Significant Difference ◽  
And Control

Purpose: To investigate the levels of circulating CD34+ stem cells in patients with neovascular type age-related macular degeneration (AMD) and its relation with clinical and optical coherence tomography (OCT) findings. Methods: The study consisted of 55 patients: 28 patients (18 male and 10 female) with neovascular type AMD as a study group and 27 patients (12 male and 15 female) scheduled for cataract surgery as a control group. The level of CD34+ stem cells was measured by flow cytometry. Demographic and clinical data were recorded. Results: The mean ages of patients in the study and control groups were 71 ± 8 and 68 ± 6 years, respectively. There was no statistically significant difference in terms of age, sex, or systemic disease association between study and control groups. However, smoking status was significantly higher in the study group (67.9% vs 37.0%; p = 0.02). Stem cell levels were significantly higher in the study group (1.5 ± 0.9 vs 0.5 ± 0.3; p<0.001), but there was no relation between stem cell levels and clinical and OCT findings. Conclusions: Increased circulating CD34+ stem cell levels were observed in patients with choroidal neovascular membrane associated with AMD, but no significant relation was found between cell levels and clinical and OCT findings.

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