Subretinal Drusenoid Deposits and the Loss of Rod Function in Intermediate Age-Related Macular Degeneration

2018 ◽  
Vol 59 (10) ◽  
pp. 4154 ◽  
Author(s):  
Rose Tan ◽  
Robyn H. Guymer ◽  
Chi D. Luu
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Rod Function ◽  
Subretinal Drusenoid Deposits

scholarly journals Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manjot Kaur Grewal ◽  
Shruti Chandra ◽  
Alan Bird ◽  
Glen Jeffery ◽  
Sobha Sivaprasad
Keyword(s):  
Macular Degeneration ◽  
Healthy Aging ◽  
Intraclass Correlation ◽  
Age Related Macular Degeneration ◽  
Healthy Individuals ◽  
Age Related ◽  
Rod Function ◽  
The Mean ◽  
Highly Correlated ◽  
Effect Of Age

AbstractTo evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals. The mean sensitivity (MS) and pointwise retinal sensitivities (PWS) within the central 24° with 505 nm (cyan) and 625 nm (red) stimuli were evaluated in 50 individuals (11 healthy and 39 AMD eyes). The overall intra- and intersession had excellent reliability (intraclass correlation coefficient, ICC > 0.90) and tests were highly correlated (Spearman rs = 0.75–0.86). Eyes with subretinal drusenoid deposit (SDD) had reduced PWS centrally, particularly at inferior and nasal retinal locations compared with controls and intermediate AMD (iAMD) without SDD. There was no difference in MS or PWS at any retinal location between iAMD without SDD and healthy individuals nor between iAMD with SDD and non-foveal atrophic AMD groups. Eyes with SDD have reduced rod function compared to iAMD without SDD and healthy eyes, but similar to eyes with non-foveal atrophy. Our results highlight rod dysfunction is not directly correlated with drusen load and SDD location.

scholarly journals Longitudinal Changes in Retinotopic Rod Function in Intermediate Age-Related Macular Degeneration

2018 ◽  
Vol 59 (4) ◽  
pp. AMD19 ◽  
Author(s):  
Chinh T. Nguyen ◽  
Rogan G. Fraser ◽  
Rose Tan ◽  
Emily Caruso ◽  
Jia Jia Lek ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Longitudinal Changes ◽  
Age Related ◽  
Rod Function

Prevalence and Significance of Subretinal Drusenoid Deposits (Reticular Pseudodrusen) in Age-Related Macular Degeneration

Ophthalmology ◽  
2010 ◽  
Vol 117 (9) ◽  
pp. 1775-1781 ◽  
Author(s):  
Sandrine A. Zweifel ◽  
Yutaka Imamura ◽  
Theodore C. Spaide ◽  
Takamitsu Fujiwara ◽  
Richard F. Spaide
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Reticular Pseudodrusen ◽  
Age Related ◽  
Subretinal Drusenoid Deposits

scholarly journals Drusen Characteristics of Type 2 Macular Neovascularization in Age-related Macular Degeneration

2020 ◽  
Author(s):  
Daniel Ahmed ◽  
Martin Stattin ◽  
Anna-Maria Haas ◽  
Alexandra Graf ◽  
Katharina Krepler ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Care Center ◽  
Age Related Macular Degeneration ◽  
Retrospective Data Analysis ◽  
Age Related ◽  
The Relationship ◽  
Subretinal Drusenoid Deposits ◽  
Medical Retina ◽  
Fellow Eyes

Abstract Background: To assess the relationship between drusen characteristics and type 2 macular neovascularization (MNV) in age-related macular degeneration (AMD)Methods: Retrospective data analysis of eyes previously diagnosed with neovascular AMD in a tertiary eye care center (Medical Retina Unit, Rudolf Foundation Hospital, Vienna, Austria) between June 2008 and December 2017. Drusen subtypes, fibrosis, atrophy and subfoveal choroidal thickness (SFCT) of both eyes in patients with type 2 MNV lesions were categorized based on multimodal imaging.Results: Type 2 MNV was diagnosed in 27 (3.2%) of 835 eyes (749 patients). Drusen characteristics in type 2 MNV were observed as followed: drusen < 63 mm in 2 eyes (7.4%), drusen ≥ 63 mm in 10 eyes (37%), subretinal drusenoid deposits (SDD) in 8 eyes (29.6%), cuticular drusen in 2 eye (7.4%) and no drusen were evident in 10 eyes (37%). Drusen distribution in 23 fellow eyes was detected as followed: drusen < 63 mm in 2 eyes (8.7%), drusen ≥ 63 mm in 9 eyes (39.1%), SDD in 5 eyes (21.7%), cuticular drusen in 1 eye (4.3%) and no drusen were evident in 9 eyes (39.1%). Mean SFCT was 140 ± 49 mm in affected eyes and 152 ± 41 mm in the fellow eyes. Patients with drusen or SDD were significantly younger (mean 70.88 ± 6.85, p=0.04) than patients without deposits (mean 77.40 ± 5.74). Conclusions: Type 2 MNV remains a rare entity in AMD. It was frequently seen in the absence ofdrusen, a hallmark of AMD. These findings contribute to the heterogeneity of phenotypes related to pure type 2 lesions.

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