scholarly journals Tear Film–Oriented Diagnosis and Tear Film–Oriented Therapy for Dry Eye Based on Tear Film Dynamics

2018 ◽  
Vol 59 (14) ◽  
pp. DES13 ◽  
Author(s):  
Norihiko Yokoi ◽  
Georgi As Georgiev
Keyword(s):  
Dry Eye ◽  
Tear Film

Ayurvedic Management of Dry Eye Sydrome - A Case Study

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Hemalatha S. ◽  
Rati S.
Keyword(s):  
Dry Eye ◽  
Treatment Modality ◽  
Similar Condition ◽  
Symptomatic Relief ◽  
Tear Film ◽  
Modern Medicine ◽  
Common Condition ◽  
Dry Out ◽  
Tear Substitute

Dry eye syndrome is a common condition that results from reduced tear production or excessive tear evaporation or an abnormality in the production of mucus or lipids normally found in the tear layer or combination of these. If blinking is decreased or if the eyelids cannot be closed, they may dry out leading to dry eye. It is accompanied by increased osmolarity of the tear film and inflammation on the surface of the eye may occur of left untreated leading to pain, ulcers or scars on the cornea and loss of vision. Prevalence of dry eye range from 5% to 35% worldwide while in India it is 29.25%. Tear substitute are the only treatment modality with modern medicine, only providing symptomatic relief. Ayurveda describes similar condition called Sushkakshi Paka and this patient was treated with Tarpana and Nasya with Jeevantyadi Ghrita.

scholarly journals Tear Proteomics Study of Dry Eye Disease: Which Eye Do You Adopt as the Representative Eye for the Study?

2021 ◽  
Vol 22 (1) ◽  
pp. 422
Author(s):  
Ming-Tse Kuo ◽  
Po-Chiung Fang ◽  
Shu-Fang Kuo ◽  
Alexander Chen ◽  
Yu-Ting Huang
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Mechanistic Studies ◽  
Clinical Tests ◽  
Tear Proteins ◽  
Proteomic Data ◽  
Surface Performance

Most studies about dry eye disease (DED) chose unilateral eye for investigation and drew conclusions based on monocular results, whereas most studies involving tear proteomics were based on the results of pooling tears from a group of DED patients. Patients with DED were consecutively enrolled for binocular clinical tests, tear biochemical markers of DED, and tear proteome. We found that bilateral eyes of DED patients may have similar but different ocular surface performance and tear proteome. Most ocular surface homeostatic markers and tear biomarkers were not significantly different in the bilateral eyes of DED subjects, and most clinical parameters and tear biomarkers were correlated significantly between bilateral eyes. However, discrepant binocular presentation in the markers of ocular surface homeostasis and the associations with tear proteins suggested that one eye’s performance cannot represent that of the other eye or both eyes. Therefore, in studies for elucidating tear film homeostasis of DED, we may lose some important messages hidden in the fellow eye if we collected clinical and proteomic data only from a unilateral eye. For mechanistic studies, it is recommended that researchers collect tear samples from the eye with more severe DED under sensitive criteria for identifying the more severe eye and evaluating the tear biochemical and proteomic markers with binocular concordance drawn in prior binocular studies.

A distinct cytokines profile in tear film of dry eye disease (DED) patients with HIV infection

Cytokine ◽  
2016 ◽  
Vol 88 ◽  
pp. 77-84 ◽  
Author(s):  
Rupesh Agrawal ◽  
Praveen Kumar Balne ◽  
Anuradha Veerappan ◽  
Veonice Bijin Au ◽  
Bernett Lee ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease

Corneal topography and classical test in the diagnosis of dry eye syndrome in patients with myopia and myopic astigmatism before keratorefractive surgery

2021 ◽  
pp. 39-43
Author(s):  
Y.V. Kutuzova ◽  
◽  
I.V. Dutchin ◽  
E.L. Sorokin ◽  
◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Risk Groups ◽  
Corneal Topography ◽  
Dry Eye Syndrome ◽  
Film Rupture ◽  
Keratorefractive Surgery ◽  
The Stability ◽  
High Degree ◽  
Myopic Astigmatism

Purpose.To conduct a comparative analysis of the effectiveness of assessing the stability of the tear film using corneotopography and the classic Norn test in patients with myopia and myopic astigmatism before keratorefractive surgery. Material and methods. The study included 26 patients planned for keratorefractive surgery for myopia and myopic astigmatism, aged 18 to 47 years. 7 people there was a mild degree of myopia, in 14 people – medium degree, in 5 people – high degree. The average degree of corneal astigmatism was 2.25 diopters. The stability of the pre-corneal tear film was assessed using computed keratotopography and Norn's test – the tear film rupture time (TFRT) was deter- mined. A standard questionnaire was also used to assess the severity of symptoms of dry eye syndrome. A comparison was made of the indicators of the stability of the tear film obtained by the methods of corneotopography and the Norn's test, with their subsequent comparison with the data of the questionnaire. Results. In 17 patients (65.4%), the TFRT index corresponded to the age norm. In the remaining 9 people (34.6%), indicators of stability of the tear film were reduced both by corneotopography (12±4 sec) and by Norn's test (13.5±4.5 sec), and there were also subjective signs of dry eye syndrome according to data questionnaire. The data turned out to be comparable. Conclusions. 1. Among the total population of patients, 34.6% were persons with impaired tear film stability and subjective manifestations of dry eye syndrome. 2. Assessment of the stability of the tear film, determined using the method of corneal topography, showed a high degree of comparability with the results of Norn's test. A significant advantage of the keratotopography method is its non-invasiveness. 3. It is necessary to pay attention to the condition of the ocular surface and identify risk groups to avoid chronicity or aggravation of existing disorders. Key words: dry eye syndrome, tear film, keratotopography, Norn's test.

«Dry eye» syndrome and primary glaucoma: possibilities of treatment

Reflection ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 42-44
Author(s):  
L.I. Solovyova ◽  
◽  
T.V. Gavrilova ◽  
F.G. Mugumova ◽  
◽  
...  
Keyword(s):  
Dry Eye ◽  
Open Angle Glaucoma ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Rupture Time ◽  
Eye Drops ◽  
Film Rupture ◽  
Good Tolerability ◽  
Primary Glaucoma ◽  
The Stability

The article presents the results of Ocuhyl C using in the treatment of «dry eye syndrome» (DES) in 47 eyes of 26 patients with different stages of compensated primary open-angle glaucoma. Experience of instillation of hypotensive eye drops with preservatives was from 1 year to 35 years. Assessment of subjective signs of DES was performed by questioning. Functional tests were performed (for the stability of the precorneal tear film –Norn test, for the level of total tear production –Shirmer test). Examinations were carried out at the first examination before prescribing the drug, then after 4 and 8 weeks of its use. All the patients noted good tolerability of the drug, no side effects. Indicators characterizing the feeling of a foreign body, dryness and redness of the eyes have significantly decreased. Precorneal tear film rupture time has significantly increased. Ocuhyl C can be recommended for clinical use. Key words: primary glaucoma; “dry eye” syndrome; tear forming; tear film rupture time; Ocuhyl C.

scholarly journals Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Mária Budai-Szűcs ◽  
Gabriella Horvát ◽  
Barnabás Áron Szilágyi ◽  
Benjámin Gyarmati ◽  
András Szilágyi ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Thiol Groups ◽  
Physiological Properties ◽  
Disulphide Bond Formation ◽  
Polymer Bearing

Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease.

scholarly journals Comparable effects on tear film parameters after femtosecond laser-assisted and conventional cataract surgery

2020 ◽  
Vol 40 (11) ◽  
pp. 3097-3104 ◽  
Author(s):  
Marc Schargus ◽  
Svetlana Ivanova ◽  
Gesa Stute ◽  
H. Burkhard Dick ◽  
Stephanie C. Joachim
Keyword(s):  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Dry Eye ◽  
Surgical Techniques ◽  
Tear Film ◽  
Schirmer Test ◽  
Fluorescein Staining ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Abstract Purpose Dry eye symptoms after conventional cataract surgery are a very common problem. Until now, only few data are available on objective tear film parameters in regard to femtosecond laser-assisted cataract surgery (LCS). Aim of this study was therefore to analyze and compare tear film parameter changes between LCS and conventional cataract surgery. Methods A consecutive group of 34 patients, scheduled for cataract surgery, were randomly selected for either LCS or conventional cataract surgery (17 patients/group). Tear film assessments including tear film osmolarity, Schirmer test, MMP-9 analysis via quantitative ELISA, corneal sensitivity, corneal fluorescein staining, and conjunctival fluorescein staining were sequentially evaluated pre- as well as 1 and 3 months postoperatively. Results Both groups showed no significant difference in baseline characteristics. All surgeries were performed without any complications. After 1 and 3 months, there was no statistically significant difference in regard to tear film osmolarity (1 month: p = 0.81, 3 months: p = 1.0), Schirmer test (1 month: p = 0.35, 3 month: p = 0.08), and MMP-9 concentration (1 month: p = 0.36, 3 month: p = 0.28) between the two groups. Conclusions Neither LCS nor conventional cataract surgery affected objective tear film parameters significantly during our 3-month postoperative observation period. Hence, both surgical techniques can be equally used to treat patients without prior dry eye symptoms.

scholarly journals Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections

2018 ◽  
Vol 103 (8) ◽  
pp. 1024-1029 ◽  
Author(s):  
Ryan J Diel ◽  
Jodi Hwang ◽  
Zachary A Kroeger ◽  
Roy C Levitt ◽  
Constantine D Sarantopoulos ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Chronic Migraine ◽  
Dry Eye ◽  
Botulinum Toxin A ◽  
Demographic Data ◽  
Tear Film ◽  
Phenol Red ◽  
Toxin A ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

BackgroundTo evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptoms in these patients.MethodsRetrospective review of 76 patients who received BoNT-A for chronic migraine between 23 August 2017 and 13 December 2017 at the Miami Veterans Affairs Medical Center Neurotoxin Clinic. Demographic data and all comorbidities were queried via chart review. Standardised validated surveys were administered to assess symptoms prior to and after BoNT-A injection. Preinjection tear volumes were obtained using the phenol red thread (PRT) test.ResultsPreinjection migraine, photophobia and dry eye symptom scores were all significantly correlated, p<0.05, and none were associated with preinjection PRT results. After BoNT-A, improvements in migraine, photophobia and dry eye symptoms were also significantly correlated, p<0.05 and similarly did not associate with preinjection PRT results. Photophobia scores significantly improved following BoNT-A, while dry eye symptoms significantly improved in those with severe symptoms at baseline (DEQ-5 score ≥12), p=0.027. In logistic regression analysis of all individuals with dry eye symptoms (DEQ-5 ≥6), individuals with more severe dry eye symptoms were more likely improve, OR 1.27, 95% CI 1.06 to 1.51, p<0.01.ConclusionsBoNT-A significantly improved photophobia in patients being treated for migraine and also improved dry eye symptoms in patients with severe symptoms at baseline, independent of baseline tear film volume. These improvements may be due to modulation of shared trigeminal neural pathways.

scholarly journals PENGARUH EMISI DEBU SEMEN TERHADAP STATUS TEAR FILM MASYARAKAT DI SEKITAR PABRIK PT. SEMEN PADANG

2018 ◽  
Vol 6 (3) ◽  
pp. 654
Author(s):  
Muhammad Syauqie ◽  
Ardizal Rahman ◽  
Getry Sukmawati
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Cross Sectional Study ◽  
Dry Eye Syndrome ◽  
Sectional Study ◽  
Cross Sectional ◽  
Break Up

Permukaan okular rentan terhadap efek iritatif dari debu semen tersebut karena epitel konyungtiva dan kornea hanya dilapisi oleh lapisan tipis tear film. Paparan debu semen jangka panjang menyebabkan terjadinya inflamasi subklinis kronik yang dapat mempengaruhi transdiferensiasi epitel konyungtiva dan densitas sel goblet yang kemudian dapat menyebabkan timbulnya gejala dry eye syndrome. Tujuan penelitian ini adalah menilai status tear film pada masyarakat  yang  terpapar  emisi  debu  semen  dibandingkan  dengan  masyarakat  yang  tidak  terpapar.  Penelitian ini berupa analytic cross sectional study pada dua populasi yaitu kelompok terpapar dan tidak terpapar emisi debu pabrik semen. Semua sampel penelitian dari dua populasi menjalani pemeriksaan pH tear film, Schirmer, Ferning dan Tear Break Up Time (TBUT). Hasil studi mendapatkan peningkatan nilai pH tear film yang bermakna pada penduduk di kelompok terpapar dengan p=0.001. Terdapat juga penurunan kualitas Ferning yang bermakna pada penduduk di kelompok terpapar yang didominasi tipe III dengan p=0.005 dan 0.029. Sedangkan hasil pemeriksaan Schirmer dan TBUT masih dalam batas normal dan tidak terdapat perbedaan yang bermakna antara kedua kelompok. Simpulan studi ini ialah erdapat peningkatan rerata nilai pH tear film dan penurunan kualitas lapisan musin tear film yang bermakna pada masyarakat yang terpapar emisi debu semen namun tidak didapatkan peningkatan kejadian dry eye yang bermakna.

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