scholarly journals Modeling the Origin of the Ocular Pulse and Its Impact on the Optic Nerve Head

2018 ◽  
Vol 59 (10) ◽  
pp. 3997 ◽  
Author(s):  
Yuejiao Jin ◽  
Xiaofei Wang ◽  
Liang Zhang ◽  
Jost B. Jonas ◽  
Tin Aung ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Ocular Pulse

scholarly journals Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head

2019 ◽  
Author(s):  
Yuejiao Jin ◽  
Xiaofei Wang ◽  
Sylvi Febriana Rachmawati Irnadiastputri ◽  
Rosmin Elsa Mohan ◽  
Tin Aung ◽  
...  
Keyword(s):  
Heart Rate ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Solid Phase ◽  
Loss Modulus ◽  
Academic Research ◽  
Fluid Phase ◽  
Biomechanical Behavior ◽  
Pulse Volume ◽  
Ocular Pulse

ABSTRACTPurposeTo study the effect of changing heart rate on the ocular pulse and the dynamic biomechanical behaviour of the optic nerve head (ONH) using a comprehensive mathematical model.MethodsIn a finite element model of a healthy eye, a biphasic choroid consisted of a solid phase with connective tissues and a fluid phase with blood, and the lamina cribrosa (LC) was viscoelastic as characterized by a stress-relaxation test. We applied arterial pressures at 18 ocular entry sites (posterior ciliary arteries) and venous pressures at four exit sites (vortex veins). In the model, the heart rate was varied from 60 bpm to 120 bpm (increment: 20 bpm). We assessed the ocular pulse amplitude (OPA), pulse volume, ONH deformations and the dynamic modulus of the LC at different heart rates.ResultsWith an increasing heart rate, the OPA decreased by 0.04 mmHg for every 10 bpm increase in heart rate. The ocular pulse volume decreased linearly by 0.13 µL for every 10 bpm increase in heart rate. The storage modulus and the loss modulus of the LC increased by 0.014 MPa and 0.04 MPa, respectively, for every 10 bpm increase in heart rate.conclusionsIn our model, the OPA, pulse volume, and ONH deformations decreased with an increasing heart rate, while the LC became stiffer. The effects of blood pressure / heart rate changes on ONH stiffening may be of interest for glaucoma pathology.SupportSingapore Ministry of Education, Academic Research Fund, Tier 2 (R-397-000-280-112).Commercial relationshipNone

scholarly journals Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head

2020 ◽  
Vol 61 (4) ◽  
pp. 27
Author(s):  
Yuejiao Jin ◽  
Xiaofei Wang ◽  
Sylvi Febriana Rachmawati Irnadiastputri ◽  
Rosmin Elsa Mohan ◽  
Tin Aung ◽  
...  
Keyword(s):  
Heart Rate ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Biomechanical Behavior ◽  
Ocular Pulse

scholarly journals Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Min Kyung Song ◽  
Joong Won Shin ◽  
Jin Yeong Lee ◽  
Ji Wook Hong ◽  
Michael S. Kook
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Open Angle Glaucoma ◽  
Spatial Relationship ◽  
Vascular Supply ◽  
Open Angle ◽  
Regression Analyses ◽  
Angular Extent ◽  
Choroidal Vessels

AbstractThe presence of parapapillary choroidal microvasculature dropout (CMvD) may affect optic nerve head (ONH) perfusion in glaucoma patients, since parapapillary choroidal vessels provide vascular supply to the neighboring ONH. However, it remains to be determined whether the presence of parapapillary CMvD is associated with diminished perfusion in the nearby ONH. The present study investigated the spatial relationship between CMvD and ONH vessel density (ONH-VD) loss in open-angle glaucoma (OAG) eyes using optical coherence tomography angiography (OCT-A). This study included 48 OAG eyes with a single localized CMvD confined to the inferotemporal parapapillary sector and 48 OAG eyes without CMvD, matched for demographic and ocular characteristics. Global and regional ONH-VD values were compared between eyes with and without CMvD. The relationships between ONH-VD outcomes and clinical variables were assessed. ONH-VDs at the inferotemporal ONH sectors corresponding to the CMvD location were significantly lower in eyes with compared to those without CMvD. Multivariable linear regression analyses indicated that a lower inferotemporal ONH-VD was independently associated with CMvD presence and a greater CMvD angular extent (both P < 0.05). The localized presence of parapapillary CMvD in OAG eyes is significantly associated with ONH-VD loss in the neighboring ONH location, with a spatial correlation.

scholarly journals Coloboma of the Optic Nerve Head in Benbal Tiger Kittens (Panthera tigris tigris)

1985 ◽  
Vol 26 (1) ◽  
pp. 136-139
Author(s):  
H. H. Dietz ◽  
E. Eriksen ◽  
O. A. Jensen
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Panthera Tigris ◽  
Panthera Tigris Tigris

scholarly journals Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ana Amorim-de-Sousa ◽  
Tim Schilling ◽  
Paulo Fernandes ◽  
Yeshwanth Seshadri ◽  
Hamed Bahmani ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Electrical Activity ◽  
Blue Light ◽  
Optic Nerve Head ◽  
Plexiform Layer ◽  
Pattern Electroretinogram ◽  
Blind Spot ◽  
Inner Plexiform Layer ◽  
Pattern Erg ◽  
Myopia Progression

AbstractUpregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p < 0.001) and 10 min (p < 0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for ‘Time after stimulation’ (p < 0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system.

scholarly journals Large-scale machine learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology

2021 ◽  
Author(s):  
Babak Alipanahi ◽  
Farhad Hormozdiari ◽  
Babak Behsaz ◽  
Justin Cosentino ◽  
Zachary R. McCaw ◽  
...  
Keyword(s):  
Machine Learning ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Large Scale ◽  
Head Morphology

Blind Source Separation of Retinal Pulsatile Patterns in Optic Nerve Head Video-Recordings

2020 ◽  
pp. 1-1
Author(s):  
Ivana Labounkova ◽  
Rene Labounek ◽  
Igor Nestrasil ◽  
Jan Odstrcilik ◽  
Ralf P. Tornow ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Blind Source Separation ◽  
Optic Nerve Head ◽  
Source Separation ◽  
Video Recordings
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