scholarly journals Deep Defects Seen on Visual Fields Spatially Correspond Well to Loss of Retinal Nerve Fiber Layer Seen on Circumpapillary OCT Scans

2018 ◽  
Vol 59 (2) ◽  
pp. 621 ◽  
Author(s):  
Maria A. Mavrommatis ◽  
Zhichao Wu ◽  
Saskia I. Naegele ◽  
Jason Nunez ◽  
Carlos Gustavo De Moraes ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Visual Fields ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber ◽  
Deep Defects

The effect of mirtogenol towards the changes in retinal nerve fiber layer thickness and visual field in primary open angle glaucoma

2019 ◽  
Vol 43 (1) ◽  
pp. 28
Author(s):  
Astriviani Widyakusuma ◽  
Widya Artini ◽  
Virna Dwi Oktariana ◽  
Joedo Prihartono
Keyword(s):  
Visual Field ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Open Angle Glaucoma ◽  
Visual Fields ◽  
Mean Deviation ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

Objective: To evaluate the effect of Mirtogenol towards the changes in retinal nerve fiber layer (RNFL) thickness and visual field in patients with primary open angle glaucoma (POAG) with controlled IOP. Methods: This is a prospective, double blind, randomized study. Forty one POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after the treatment. Patients were asked for any side effects during the treatment period. Result: The average RNFL thickness in the Mirtogenol group decreased -0.70±1.63 μm from 87.29±19.39 μm before the treatment to 86.58±19.43 μm after 8 weeks of treatment, however the change was not significant (p=0.121). The average RNFL thickness in the placebo group decreased -1.74±1.79 μm from 97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of treatment, the change was statistically significant (p< 0.001). The average MD of visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of treatment while the MD of visual field in the placebo group decreased -0.083±1.36 dB after 8 weeks of treatment. Hoewever the changes in MD of visual field was not significant (p>0.05). No side effect was found throughout the study. Conclusion: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields.

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