scholarly journals Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography

2018 ◽  
Vol 59 (3) ◽  
pp. 1263 ◽  
Author(s):  
Matthias Brunner ◽  
Vito Romano ◽  
Bernhard Steger ◽  
Riccardo Vinciguerra ◽  
Samuel Lawman ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Corneal Neovascularization ◽  
Fluorescence Angiography ◽  
Optical Coherence

scholarly journals Vascular parameters of normal cynomolgus macaques and healthy humans obtained by fundus fluorescence angiography and optical coherence tomography angiography

2019 ◽  
Author(s):  
Jingyi Peng ◽  
Liuxueying Zhong ◽  
Li Ma ◽  
Jiayi Jin ◽  
Yongxin Zheng ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Parameter ◽  
Fluorescence Angiography ◽  
Optical Coherence ◽  
Advantages And Disadvantages ◽  
Healthy Humans ◽  
En Face ◽  
Cynomolgus Macaques ◽  
Optic Discs

Abstract Background: To provide and compare normal vascular parameters for cynomolgus macaques and healthy humans, compare the advantages and disadvantages of fundus fluorescence angiography (FFA) and optical coherence tomography angiography (OCT-A) in angiography, and establish an eye parameter database for cynomolgus macaques and healthy humans. Methods: 5 normal cynomolgus macaques with a mean age of 4.60±0.55 years were studied for data collection. A Heidelberg Spectralis® HRA+OCT was used to obtain parameters for FFA. The macula of 28 healthy humans (14 males and 14 females), with a mean age of 25.11±6.21 years and the optic discs of 9 healthy humans (4 males and 5 females) with a mean age of 28.56±6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macula and optic discs were 3×3 mm and 4.5×4.5 mm, respectively. Results: FFA of cynomolgus macaques revealed stages similar to those observed in humans. OCT-A was used to image the superficial and deep capillary plexuses and radial peripapillary capillary network. The highest entire en-face mean VD in the macular area was 68.19±0.75% in the choroid capillary layer. In both layers of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions: This study provides normal vascular parameters for cynomolgus macaques using FFA and OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration: Current Controlled Trials NCT03692169

scholarly journals Secondary choroidal neovascularization due to choroidal osteoma after 9 years follow-up

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yun Zhang ◽  
Jia Fang ◽  
Shixin Zhao ◽  
Xiangjun She ◽  
Jun Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Choroidal Neovascularization ◽  
Optical Coherence Tomography Angiography ◽  
Fluorescence Angiography ◽  
Optical Coherence ◽  
Vascular Changes ◽  
Choroidal Osteoma ◽  
The Right

Abstract Background Choroidal osteoma is a benign intraocular tumor that can increase risk of developing choroidal neovascularization. The visual prognosis is influenced by the tumor location, decalcification status, overlying RPE atrophy, presence of choroidal neovascularization, persistence of subretinal fluid and occurrence of subretinal hemorrhages. Case presentation The authors present a 40-year-old woman diagnosed with choroidal osteoma of the right eye. Her best corrected visual acuity was 12/20 but decreased to 5/20 due to secondary choroidal neovascularization after 8 years follow up. Fundus examination revealed an enlarged choroidal osteoma in most margins at posterior pole with schistose hemorrhage beside macula. Optical coherence tomography angiography revealed unique features in the vascular changes of choroidal neovascularization in choroidal osteoma in the outer retinal layer and choroid capillary layers, and subretinal neovascularization. Indocyanine green fluorescence angiography showed there was hypo-fluorescence at the peripapillary with faint hyper-fluorescence at the macular, corresponding to the location on the fundus photograph. The patient received 3 injections of intravitreal ranibizumab. After 1 year follow up, her visual acuity of the right eye was 18/20 and the CNV had regressed. Conclusions We present the findings and treatment of a case of choroidal osteoma with secondary choroidal neovascularization. Optical coherence tomography angiography combined with FFA and ICGA is used to analysis the characteristics of secondary choroidal neovascularization. Optical coherence tomography angiography can reveal some unique characteristics in the vascular changes compared to fundus fluorescein angiography.

scholarly journals Microvasculature Features of Vogt-Koyanagi-Harada Disease Revealed by Widefield Swept-Source Optical Coherence Tomography Angiography

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaoyuan Ye ◽  
Haiping Zhang ◽  
Peng Xiao ◽  
Gengyuan Wang ◽  
Xiaoqing Hu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Acute Phase ◽  
Optical Coherence Tomography Angiography ◽  
Fluorescence Angiography ◽  
Retinal Vasculature ◽  
Imaging Features ◽  
Optical Coherence ◽  
Swept Source ◽  
Convalescent Phase ◽  
Vkh Disease

Background: Vogt-Koyanagi-Harada (VKH) disease is a multisystem autoimmune disorder which could induce bilateral panuveitis involving the posterior pole and peripheral fundus. Optical coherence tomography angiography (OCTA) provides several advantages over traditional fluorescence angiography for revealing pathological abnormalities of the retinal vasculature. Until recently, however, the OCTA field of view (FOV) was limited to 6 × 6 mm2 scans.Purpose: This study examined retinal vasculature and choriocapillaris abnormalities across multiple regions of the retina (15 × 9 mm2 wide field, macular, peripapillary regions) among acute and convalescent VKH patients using a novel widefield swept-source OCTA (WSS-OCTA) device and assessed correlations between imaging features and best-corrected visual acuity (BCVA).Methods: Twenty eyes of 13 VHK disease patients in the acute phase, 30 eyes of 17 patients in the convalescent phase, and 30 eyes of 15 healthy controls (HCs) were included in this study. Vascular length density (VLD) in superficial and deep vascular plexuses (SVP, DVP), vascular perfusion density (VPD) in SVP, DVP, and choriocapillaris (CC), and flow voids (FV) in CC were measured across multiple retinal regions via WSS-OCTA (PLEX Elite 9000, Carl Zeiss Meditec Inc., USA) using the 15 × 9 mm2 scan pattern centered on the fovea and quantified by ImageJ.Results: Compared to HCs, acute phase VKH patients exhibited significantly reduced SVP-VLD, SVP-VPD, and CC-VPD across multiple retinal regions (all p < 0.01). Notably, the FV area was more extensive in VKH patients, especially those in the acute phase (p < 0.01). These changes were reversed in the convalescent phase. Stepwise multiple linear regression analysis demonstrated that macular DVP-VLD and macular CC-VPD were the best predictive factors for BCVA in the acute and convalescent VKH groups.Conclusion: The wider field of SS-OCAT provides more comprehensive and detailed images of the microvasculature abnormalities characterizing VKH disease. The quantifiable and layer-specific information from OCTA allows for the identification of sensitive and specific imaging markers for prognosis and treatment guidance, highlighting WSS-OCTA as a promising modality for the clinical management of VKH disease.

scholarly journals Comparison of the therapy effect of aflibercept and ranibizumab in patients with neovascular retinal pigment epithelium detachment identified by fluorescence angiography and optical coherence tomography angiography

2019 ◽  
Author(s):  
Anne Ruebsam ◽  
Pohlmann Dominika ◽  
Dietrich-Ntoukas Tina ◽  
Müller Bert ◽  
Antonia M Joussen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Fluorescence Angiography ◽  
Optical Coherence ◽  
Pigment Epithelium Detachment ◽  
Therapy Effect ◽  
Cnv Detection ◽  
Therapy Switch

Abstract Background To report on the current methods for choroidal neovascularization (CNV) detection and the clinical outcome of intravitreal therapies in patients with neovascular pigment epithelium detachment (PED). Methods Retrospective, interventional cohort study on 77 eyes of 59 patients. Inclusion criteria were a neovascular PED, identified by fluorescence angiography (FA) or/and optical coherence tomography angiography (OCTA) treated with aflibercept (16 eyes) or ranibizumab monotherapy (36 eyes) or with at least three injections of ranibizumab, with a therapy switch to aflibercept in case of persistent fluid (25 eyes). The therapy regimen was a pro re nata (PRN) scheme with an upload phase of three monthly injections. Outcome measures were sensitivity of CNV detection and evaluation of CNV activity at baseline on FA compared to OCTA, the change in highest retinal prominence (HRP) and PED size, assessed by spectral - domain OCT (SD-OCT), and the change in best-corrected visual acuity (BCVA) three months after therapy initiation in the monotherapy groups or after the switch. Results Sensitivity of CNV detection was slightly superior for FA (0.786) compared to OCTA (0.706), whereas CNV activity evaluation was superior on OCTA. HRP significantly decreased after aflibercept (p<0.001) or ranibizumab monotherapy (p<0.001), and after therapy switch to aflibercept (p<0.001) in ranibizumab refractory patients. Corresponding BCVA improved in these groups, but without statistical significance (p=0.46; p = 0.11; p=0.19). PED size significantly decreased after aflibercept monotherapy (p=0.001) or after therapy switch to aflibercept (p<0.001), but not after ranibizumab. Conclusions The combination of FA and OCTA offers significantly improved visualisation, quantification, and predictability of CNV activity in neovascular PED. Aflibercept and ranibizumab are effective treatment options for neovascular AMD with PED, with a stronger effect of aflibercept on the PED itself. Furthermore, aflibercept appears to be a valuable tool for the management of patients unresponsive to ranibizumab.

scholarly journals Optical Coherence Tomography Angiography in Herpetic Leucoma

2021 ◽  
Author(s):  
Inês Almeida ◽  
Libânia Dias ◽  
Jeniffer Jesus ◽  
Inês Fonseca ◽  
Maria João Matias ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Anterior Segment ◽  
Central Area ◽  
Corneal Neovascularization ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Monitor Treatment Response

Abstract Background: Herpes simplex virus (HSV) keratitis remains a leading infectious cause of blindness worldwide. This study instends to investigate the potential of Optical Coherence Tomography Angiography (OCTA) device to image and describe quantitatively the vascularization in eyes diagnosed with herpetic leucoma and to discuss and review the usefulness of this technique in this pathology. Methods: A Cross-sectional study was made, including 17 eyes of 15 patients with leucoma secondary to herpetic keratitis. All eyes underwent anterior segment Slit-Lamp photography (SLP), and Optical Coherence Tomography Angiography (OCT) with en-face, b-scans and c-scans imaging. The vessel density (VD) was analyzed in the inferior, nasal and temporal corneal margin in all patients, and in the central area, in eyes with central corneal neovascularization (CoNV). The measurements were calculated after binarization with ImageJ software, using OCTA scans with 6x6 mm in a depth of 800 μm. Results: Patients included had a mean age 53.267±21.542 (years±SD). The mean total vessel area was 50.907±3.435%. VD was higher in the nasal quadrant (51.156±4.276) but there were no significant differences between the three analyzed areas (p=0.940). OCTA was able to identify abnormal vessels when SLP apparently showed no abnormal vessels; OCTA was able to distinguish between larger and smaller vessels even in central cornea; OCTA scans allowed the investigation of several corneal planes and the relation of them with clinical findings. Conclusions: OCTA can be useful in both qualitative and quantitative follow-up of patients and may become a non-invasive alternative to objectively monitor treatment response in eyes with corneal vascularization due to herpetic infection.

scholarly journals Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization

Cornea ◽  
2020 ◽  
Vol 39 (5) ◽  
pp. 598-604 ◽  
Author(s):  
Afshan Nanji ◽  
Travis Redd ◽  
Winston Chamberlain ◽  
Julie M. Schallhorn ◽  
Siyu Chen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Corneal Neovascularization ◽  
Optical Coherence
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