scholarly journals Comparison of Sectoral Structure-Function Relationships in Glaucoma: Vessel Density Versus Thickness in the Peripapillary Retinal Nerve Fiber Layer

2017 ◽  
Vol 58 (12) ◽  
pp. 5251 ◽  
Author(s):  
Kimikazu Sakaguchi ◽  
Tomomi Higashide ◽  
Sachiko Udagawa ◽  
Shinji Ohkubo ◽  
Kazuhisa Sugiyama
Keyword(s):  
Structure Function ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Vessel Density ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Sectoral Structure ◽  
Retinal Nerve Fiber

scholarly journals Early Neurovascular Changes in the Retina in Preclinical Diabetic Retinopathy and Relation to Blood Glucose

2020 ◽  
Author(s):  
Hui Li ◽  
Xiaobing Yu ◽  
Bodi Zheng ◽  
Shan Ding ◽  
Zhongqing Mu ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Glucose ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Vessel Density ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Abstract Aim: To investigate the changes of retinal optic disc nerve fiber layer thickness and macular blood flow density in preclinical stage of diabetic retinopathy and their relationship with blood glucose. Methods: In this cross-sectional study,97 diabetic patients(total 188 eyes,144 eyes in no diabetic retinopathy group, 44 eyes in mild diabetic non-proliferative retinopathy group ) and 35 healthy people (70 eyes) were enrolled, All the subjects were divided into different group by HbA1c , and underwent ocular examination by optical coherence tomography angiography. We compare optical coherence tomography angiography parameter and retinal nerve fiber layer thickness among different glucose group.Results: The parafoveal vessel density and the temporal retinal nerve fiber layer thickness were lower (P < 0.05) in the diabetic group than in the normal group. The diabetic group showed a higher acircularity index as compared with the normal group. From the normal group to no diabetic retinopathy group and then to mild non-proliferative retinopathy group, vessel density decreased and acircularity index increased (P < 0.001). Foveal vascular density and parafoveal vessel density decreased with the increase of HbA1c. There was a negative correlation between parafoveal vessel density of the deep retinal vascular layer and FBG (P<0.01). The temporal retinal nerve fiber layer thickness decreased among different HbA1c levels groups and was positively correlated with the parafoveal vessel density in superficial retinal vascular layer(P<0.05).Conclusions: This study shows retinal microvasculopathy and neuropathy has been present during no retinopathy. The vessel density of the deep retinal vascular layer was negatively correlated with fasting blood glucose, and the temporal RNFL thickness was positively correlated with the vessel density of superficial retinal vascular layer. These indicators are helpful for endocrinologists and ophthalmologists to detect early diabetic retinal pathological lesions.

Does the Presence of a Disc Hemorrhage Affect OCT-Measured Vessel Density and Retinal Nerve Fiber Layer Thickness?

2018 ◽  
Vol 1 (3) ◽  
pp. 152-157
Author(s):  
Zia S. Pradhan ◽  
Shruthi Sreenivasaiah ◽  
Shivani Dixit ◽  
Harsha L. Rao ◽  
Jayasree P. Venugopal ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Vessel Density ◽  
Fiber Layer ◽  
Disc Hemorrhage ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

scholarly journals Early neurovascular changes in the retina in preclinical diabetic retinopathy and its relation with blood glucose

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Li ◽  
Xiaobing Yu ◽  
Bodi Zheng ◽  
Shan Ding ◽  
Zhongqing Mu ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Glucose ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Vessel Density ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Abstract Background To investigate the changes in retinal nerve fiber layer thickness and macular blood flow density during the preclinical stage of diabetic retinopathy and their relationship with blood glucose. Methods In this cross-sectional study, 97 diabetic patients (total of 188 eyes; 144 eyes in no diabetic retinopathy group, 44 eyes in mild diabetic non-proliferative retinopathy group) and 35 healthy people (70 eyes) were enrolled, All the subjects were divided into different groups based on their HbA1c levels, and they underwent optical coherence tomography angiography. We compared the optical coherence tomography angiography parameters and retinal nerve fiber layer thickness among the different glucose groups. Results The parafoveal vessel density and the temporal retinal nerve fiber layer thickness were lower (p < 0.05) in the diabetic group than in the normal group. The diabetic group showed a higher acircularity index than the normal group. The normal group had the highest vessel density and the lowest acircularity index, followed by the no-diabetic retinopathy group and the mild non-proliferative retinopathy group, (p < 0.001). Foveal vascular density and parafoveal vessel density decreased with an increase in HbA1c. There was a negative correlation between parafoveal vessel density in the deep retinal vascular layer and fasting blood glucose (p < 0.01). The temporal retinal nerve fiber layer thickness decreased across the HbA1c level groups, and was positively correlated with the parafoveal vessel density in the superficial retinal vascular layer (p < 0.05). Conclusions This study shows that retinal microvasculopathy and neuropathy can be present in the absence of retinopathy. The vessel density of the deep retinal vascular layer was negatively correlated with fasting blood glucose, and the temporal retinal nerve fiber layer thickness was positively correlated with the vessel density of the superficial retinal vascular layer. These indicators are helpful for endocrinologists and ophthalmologists in detecting early diabetic retinal pathological lesions.

Comparative Study of Retinal Nerve Fiber Layer Measurement by StratusOCT and GDx VCC, II: Structure/Function Regression Analysis in Glaucoma

2005 ◽  
Vol 46 (10) ◽  
pp. 3702 ◽  
Author(s):  
Christopher Kai-shun Leung ◽  
Kelvin Kam-Long Chong ◽  
Wai-man Chan ◽  
Cedric Ka-Fai Yiu ◽  
Man-yee Tso ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Comparative Study ◽  
Structure Function ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Gdx Vcc ◽  
Retinal Nerve Fiber

Macular and Optic Nerve Head Vessel Density and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma

Ophthalmology ◽  
2018 ◽  
Vol 125 (11) ◽  
pp. 1720-1728 ◽  
Author(s):  
Sasan Moghimi ◽  
Linda M. Zangwill ◽  
Rafaella C. Penteado ◽  
Kyle Hasenstab ◽  
Elham Ghahari ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Vessel Density ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

scholarly journals Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters

2017 ◽  
Vol 58 (11) ◽  
pp. 4623 ◽  
Author(s):  
Navid Amini ◽  
Ramin Daneshvar ◽  
Farideh Sharifipour ◽  
Pablo Romero ◽  
Sharon Henry ◽  
...  
Keyword(s):  
Structure Function ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber
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