scholarly journals Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION)

2017 ◽  
Vol 58 (3) ◽  
pp. 1628 ◽  
Author(s):  
Tzu-Lun Huang ◽  
Yao-Tseng Wen ◽  
Chung-Hsing Chang ◽  
Shu-Wen Chang ◽  
Kuan-Hung Lin ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuropathy ◽  
Rat Model ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Methylprednisolone Treatment

Efficacy of Vincamine treatment in a rat model of anterior ischemic optic neuropathy

2020 ◽  
pp. 112067212097428
Author(s):  
Lu Li ◽  
Yu Su ◽  
Juejun Liu ◽  
Changzheng Chen
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Optic Neuropathy ◽  
Rat Model ◽  
Ganglion Cells ◽  
Nutrition Therapy ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Retinal Ganglion ◽  
Ischemic Tissue

Non-arteritic anterior ischemic optic neuropathy (NAION) is characterized by the progressive and irreversible death of retinal ganglion cells (RGCs) which is caused by the insufficient blood supply to the optic nerve (ON) head. At present, hormone therapy is used to reduce optic edema, followed by nerve nutrition therapy to protect the ON. However, no surgical or medical therapy has proven to be beneficial consistently in treating NAION. Vincamine is an alkaloid extracted from the Apocynaceae Vinca plant. Vincamine and its derivatives acting as cerebral vasodilators can easily cross the blood-brain barrier, improve the metabolism of ischemic tissue and protect the neuron. In this study, we aimed to investigate the potential neuroprotection of Vincamine in the photodynamic induced rat model of NAION (rAION), to evaluate its effects and possible mechanisms. We found that Vincamine can rescue RGC death and reduce the number of apoptotic cells. The protection of Vincamine might play through the PI3K/Akt/eNOS signaling pathway. Therefore, Vincamine can be an effective therapy method for NAION.

scholarly journals Optic Nerve Inflammation and Demyelination in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy

2013 ◽  
Vol 54 (13) ◽  
pp. 7952 ◽  
Author(s):  
Bernard J. Slater ◽  
Fernandino L. Vilson ◽  
Yan Guo ◽  
Daniel Weinreich ◽  
Shelly Hwang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuropathy ◽  
Rodent Model ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy
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