scholarly journals Effect of Diffuse Luminance Flicker Light Stimulation on Total Retinal Blood Flow Assessed With Dual-Beam Bidirectional Doppler OCT

2017 ◽  
Vol 58 (2) ◽  
pp. 1167 ◽  
Author(s):  
Gerold C. Aschinger ◽  
Leopold Schmetterer ◽  
Klemens Fondi ◽  
Valentin Aranha Dos Santos ◽  
Gerald Seidel ◽  
...  
PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45876 ◽  
Author(s):  
René M. Werkmeister ◽  
Stefan Palkovits ◽  
Reinhard Told ◽  
Martin Gröschl ◽  
Rainer A. Leitgeb ◽  
...  

2015 ◽  
Vol 6 (5) ◽  
pp. 1599 ◽  
Author(s):  
Gerold C. Aschinger ◽  
Leopold Schmetterer ◽  
Veronika Doblhoff-Dier ◽  
Rainer A. Leitgeb ◽  
Gerhard Garhöfer ◽  
...  

2020 ◽  
Vol 105 (1) ◽  
pp. 124-130 ◽  
Author(s):  
Takafumi Yoshioka ◽  
Youngseok Song ◽  
Motofumi Kawai ◽  
Tomofumi Tani ◽  
Kengo Takahashi ◽  
...  

AimsTo evaluate the associations between retinal blood flow (RBF) and optical coherence tomography (OCT) structural measurements in normal-tension glaucoma (NTG) eyes with single-hemifield visual field (VF) damage by the Doppler OCT.MethodsThe Doppler OCT was used to measure temporal artery (TA) RBF and temporal vein (TV) RBF. Retinal nerve fibre layer thickness (RNFLT) was measured by spectral-domain OCT.ResultsForty-three consecutive eyes of 43 patients with NTG with VF defect confined to a single hemifield and 24 eyes of 24 age-matched healthy subjects were studied. TA and TV RBF and RNFLT were reduced in the damaged hemisphere compared with the normal hemisphere (mean (SD), 3.61 (1.68) vs 5.86 (2.59) µL/min, p<0.001; 5.61 (2.51) vs 6.94 (2.83) µL/min, p=0.010; 69.0 (19.7) vs 99.7 (22.8) µm, p<0.001). Those values in the normal hemisphere of NTG eyes also decreased compared with the healthy hemisphere of the healthy eyes (8.40 (3.36) µL/min, p<0.001; 9.28 (4.47) µL/min, p<0.002; 122.8 (20.2) µm, p<0.001). Multivariate model showed that normal and damaged hemispheres and RNFLT were associated with RBF reduction. In addition, the RBF in the normal hemisphere was lower than that in the healthy hemisphere even after adjusting for RNFLT.ConclusionIn NTG eyes with single-hemifield damage, the RBF was significantly reduced in the damaged hemisphere compared with the normal one. The RBF decreased in the normal and damaged hemispheres of NTG eyes compared with the healthy hemisphere independent from RNFLT.


2014 ◽  
Author(s):  
Veronika Doblhoff-Dier ◽  
René M. Werkmeister ◽  
Martin Gröschl ◽  
Leopold Schmetterer

2014 ◽  
Vol 5 (2) ◽  
pp. 630 ◽  
Author(s):  
Veronika Doblhoff-Dier ◽  
Leopold Schmetterer ◽  
Walthard Vilser ◽  
Gerhard Garhöfer ◽  
Martin Gröschl ◽  
...  

Eye ◽  
2019 ◽  
Vol 34 (5) ◽  
pp. 886-891
Author(s):  
Jennifer Cano ◽  
Shayan Farzad ◽  
Maziyar M. Khansari ◽  
Ou Tan ◽  
David Huang ◽  
...  

Abstract Purpose The purpose of the current study was to determine associations between retinal blood flow and vessel morphology metrics in sickle cell retinopathy (SCR) and healthy normal control (NC) subjects. Methods Optical coherence tomography angiography (OCTA) and Doppler OCT imaging were performed in 12 SCR (15 eyes) and 19 NC (26 eyes) subjects. Vessel tortuosity was measured using a dedicated image analysis algorithm applied to OCTA images. Vessel density and spacing between vessels were determined from OCTA images by a fractal dimension analysis method. Retinal blood flow was quantified using a phase-resolved technique applied to en face Doppler OCT images. Results There was a significant association between increased retinal blood flow and increased vessel tortuosity (P = 0.03). Furthermore, increased retinal blood flow was associated with increased vessel density (P = 0.03) and decreased spacing between small vessels (P = 0.01). There was no significant association between retinal blood flow and spacing between large vessels (P = 0.11). Vessel tortuosity and blood flow were increased, whereas spacing between small vessels was decreased in SCR compared to NC group (P ≤ 0.03). There were no significant differences in vessel density or spacing between large vessels between the SCR and NC groups (P ≥ 0.31). Conclusions Associations between retinal hemodynamics and vessel morphology were reported, providing better understanding of retinal pathophysiology and insight into potential quantitative biomarkers to evaluate SCR.


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