scholarly journals Retinal Capillary Density and Foveal Avascular Zone Area Are Age-Dependent: Quantitative Analysis Using Optical Coherence Tomography Angiography

2016 ◽  
Vol 57 (13) ◽  
pp. 5780 ◽  
Author(s):  
Nicholas A. Iafe ◽  
Nopasak Phasukkijwatana ◽  
Xuejing Chen ◽  
David Sarraf
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Analysis ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Retinal Capillary ◽  
Avascular Zone ◽  
Age Dependent

Foveal avascular zone in oculocutaneous albinism

2021 ◽  
Vol 14 (5) ◽  
pp. e240208
Author(s):  
Hana A Mansour ◽  
Sami Uwaydat ◽  
Muhamad H Yunis ◽  
Ahmad M Mansour
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Oculocutaneous Albinism ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Retinal Capillary ◽  
Avascular Zone ◽  
Capillary Plexus ◽  
Foveal Hypoplasia

Optical coherence tomography angiography imaging in two patients with oculocutaneous albinism, one with severe nystagmus, showed persistence of both the superficial and the deep retinal capillary plexus adding another vascular feature to the foveal hypoplasia.

scholarly journals Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nathalie Massamba ◽  
Anna G. Mackin ◽  
Lindsay Y. Chun ◽  
Sarah Rodriguez ◽  
Rose C. Dimitroyannis ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Racial Differences ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Flow Area ◽  
Black And White ◽  
Significant Difference ◽  
Retinal Capillary

AbstractThis study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (BFA) of the fovea, parafovea and total 3 mm-diameter circular area centered on the fovea, as well as the foveal avascular zone (FAZ) parameters, controlling for axial length. Black subjects had lower foveal and parafoveal VD in the SCP (p = 0.043 and p = 0.014) and the ICP (p = 0.014 and p = 0.002). In the DCP, black subjects had a trend toward lower foveal and parafoveal VD. Black subjects had decreased choriocapillaris BFA in the total 3 mm area (p = 0.011) and the parafovea (p = 0.033), larger FAZ area (p = 0.006) and perimeter (p = 0.014), and a higher capillary density in a 300 μm wide region around the FAZ (FD-300) (p = 0.001). There was no significant difference in FAZ acircularity index. To our knowledge, this is the first report analyzing the three distinct retinal capillary plexuses and identifying differing baseline VD, choriocapillaris and FAZ parameters in healthy young black compared to white subjects. Larger studies are needed to validate these findings and better understand racial differences in vulnerability to ocular diseases.

Measurement of Normative Foveal Avascular Zone Parameters in Healthy Adults Using Optical Coherence Tomography Angiography

2018 ◽  
Vol 2 (4) ◽  
pp. 213-218 ◽  
Author(s):  
Rayan A. Alshareef ◽  
Hasenin Al-khersan ◽  
Rami Darwich ◽  
Ayesha Jabeen ◽  
Asiya Jabeen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Refractive Error ◽  
Optical Coherence Tomography Angiography ◽  
Geometric Dimension ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Retinal Capillary ◽  
Avascular Zone ◽  
Capillary Plexus ◽  
Male Sex

Background and Objective: The purpose of this study was to quantify the geometric dimension of the foveal avascular zone (FAZ) area and its index measurement of morphology as a circle (acircularity index) in healthy participants according to age and sex, using optical coherence tomography angiography (OCTA). Study Design/Materials and Method: This is a cross-sectional descriptive study conducted at LV Prasad Eye Institute, India. Written informed consent was obtained from all participants before the study. Deep range imaging-optical coherence tomography (DRI-OCT; Topcon) was performed on right eyes of all participants in this study. The OCTA scans were analyzed and processed; FAZ dimensions and the acircularity index were calculated for both superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP). Results: A total of 88 normal right eyes from 88 participants were included (48 males, 40 females; mean 42 ± 13 years of age). Mean FAZ area for SCP and DCP was 3.37 ± 1.28 mm2 and 2.31 ± 1.12 mm2, respectively. Mean acircularity index for SCP and DCP was 1.76 ± 1.58 and 1.60 ± 0.90, respectively. In the SCP, male sex was correlated with lower FAZ values; however, there was no correlation with age or refractive error. For the DCP, male sex and increasing age correlated with lower FAZ values, but there was no correlation with refractive error. Foveal avascular zone areas decreased 0.0225 mm2 per year in the DCP. The acircularity index of both the SCP and DCP was not correlated with sex, age, or refractive error. Conclusions: Male sex and increasing age were correlated with lower FAZ values in the DCP, while only male sex was correlated with lower FAZ values in the SCP. There was no correlation between sex, age, or refractive error with the acircularity index for both the SCP and DCP.

VARIABILITY IN FOVEAL AVASCULAR ZONE AND CAPILLARY DENSITY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY MACHINES IN HEALTHY EYES

Retina ◽  
2017 ◽  
Vol 37 (11) ◽  
pp. 2102-2111 ◽  
Author(s):  
George N. Magrath ◽  
Emil Anthony T. Say ◽  
Kareem Sioufi ◽  
Sandor Ferenczy ◽  
Wasim A. Samara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Avascular Zone ◽  
Healthy Eyes

scholarly journals Automatic segmentation of foveal avascular zone based on adaptive watershed algorithm in retinal optical coherence tomography angiography images

2021 ◽  
Author(s):  
Jian Liu ◽  
Shixin Yan ◽  
Nan Lu ◽  
Dongni Yang ◽  
Chunhui Fan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Automatic Segmentation ◽  
Qualitative Evaluation ◽  
Foveal Avascular Zone ◽  
Watershed Algorithm ◽  
Strong Positive Correlation ◽  
Optical Coherence ◽  
Avascular Zone

The size and shape of the foveal avascular zone (FAZ) have a strong positive correlation with several vision-threatening retinovascular diseases. The identification, segmentation and analysis of FAZ are of great significance to clinical diagnosis and treatment. We presented an adaptive watershed algorithm to automatically extract FAZ from retinal optical coherence tomography angiography (OCTA) images. For the traditional watershed algorithm, “over-segmentation” is the most common problem. FAZ is often incorrectly divided into multiple regions by redundant “dams”. This paper analyzed the relationship between the “dams” length and the maximum inscribed circle radius of FAZ, and proposed an adaptive watershed algorithm to solve the problem of “over-segmentation”. Here, 132 healthy retinal images and 50 diabetic retinopathy (DR) images were used to verify the accuracy and stability of the algorithm. Three ophthalmologists were invited to make quantitative and qualitative evaluations on the segmentation results of this algorithm. The quantitative evaluation results show that the correlation coefficients between the automatic and manual segmentation results are 0.945 (in healthy subjects) and 0.927 (in DR patients), respectively. For qualitative evaluation, the percentages of “perfect segmentation” (score of 3) and “good segmentation” (score of 2) are 99.4% (in healthy subjects) and 98.7% (in DR patients), respectively. This work promotes the application of watershed algorithm in FAZ segmentation, making it a useful tool for analyzing and diagnosing eye diseases.

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