scholarly journals Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Laser-Induced Choroidal Neovascularization in Mice

2016 ◽  
Vol 57 (13) ◽  
pp. 5348 ◽  
Author(s):  
Daisuke Ozone ◽  
Takeshi Mizutani ◽  
Miho Nozaki ◽  
Masaharu Ohbayashi ◽  
Norio Hasegawa ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Choroidal Neovascularization ◽  
Tissue Plasminogen Activator ◽  
Antiangiogenic Agent ◽  
Tissue Plasminogen

Activation of tissue plasminogen activator gene transcription by Neovastat, a multifunctional antiangiogenic agent

2004 ◽  
Vol 320 (1) ◽  
pp. 205-212 ◽  
Author(s):  
Denis Gingras ◽  
Carine Nyalendo ◽  
Geneviève Di Tomasso ◽  
Borhane Annabi ◽  
Richard Béliveau
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Gene Transcription ◽  
Antiangiogenic Agent ◽  
Tissue Plasminogen

The Antiangiogenic Agent Neovastat (Æ-941) Stimulates Tissue Plasminogen Activator Activity

2004 ◽  
Vol 22 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Denis Gingras ◽  
Dominique Labelle ◽  
Carine Nyalendo ◽  
Dominique Boivin ◽  
Michel Demeule ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Antiangiogenic Agent ◽  
Plasminogen Activator Activity ◽  
Tissue Plasminogen

Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Corneal Neovascularization in Rabbits

2018 ◽  
Vol 59 (3) ◽  
pp. 170-175
Author(s):  
Kon-ichi Arai ◽  
Tsutomu Yasukawa ◽  
Aki Kato ◽  
Ayae Kubota ◽  
Hideaki Usui ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Corneal Neovascularization ◽  
Antiangiogenic Agent ◽  
Tissue Plasminogen

Tissue plasminogen activator as a novel diagnostic aid in acute pulmonary embolism

VASA ◽  
2014 ◽  
Vol 43 (6) ◽  
pp. 450-458 ◽  
Author(s):  
Julio Flores ◽  
Ángel García-Avello ◽  
Esther Alonso ◽  
Antonio Ruíz ◽  
Olga Navarrete ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Negative Predictive Value ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Predictive Value ◽  
Acute Pulmonary Embolism ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diagnostic Utility ◽  
Tissue Plasminogen ◽  
D Dimer

Background: We evaluated the diagnostic efficacy of tissue plasminogen activator (tPA), using an enzyme-linked immunosorbent assay (ELISA) and compared it with an ELISA D-dimer (VIDAS D-dimer) in acute pulmonary embolism (PE). Patients and methods: We studied 127 consecutive outpatients with clinically suspected PE. The diagnosis of PE was based on a clinical probability pretest for PE and a strict protocol of imaging studies. A plasma sample to measure the levels of tPA and D-dimer was obtained at enrollment. Diagnostic accuracy for tPA and D-dimer was determined by the area under the receiver operating characteristic (ROC) curve. Sensitivity, specificity, predictive values, and the diagnostic utility of tPA with a cutoff of 8.5 ng/mL and D-dimer with a cutoff of 500 ng/mL, were calculated for PE diagnosis. Results: PE was confirmed in 41 patients (32 %). Areas under ROC curves were 0.86 for D-dimer and 0.71 for tPA. The sensitivity/negative predictive value for D-dimer using a cutoff of 500 ng/mL, and tPA using a cutoff of 8.5 ng/mL, were 95 % (95 % CI, 88–100 %)/95 % (95 % CI, 88–100 %) and 95 % (95 % CI, 88–100 %)/94 %), respectively. The diagnostic utility to exclude PE was 28.3 % (95 % CI, 21–37 %) for D-dimer and 24.4 % (95 % CI, 17–33 %) for tPA. Conclusions: The tPA with a cutoff of 8.5 ng/mL has a high sensitivity and negative predictive value for exclusion of PE, similar to those observed for the VIDAS D-dimer with a cutoff of 500 ng/mL, although the diagnostic utility was slightly higher for the D-dimer.

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