scholarly journals Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy

2016 ◽  
Vol 57 (6) ◽  
pp. 2578 ◽  
Author(s):  
Giuseppe Querques ◽  
Eliana Costanzo ◽  
Alexandra Miere ◽  
Vittorio Capuano ◽  
Eric H. Souied
Keyword(s):  
Optical Coherence Tomography ◽  
Geographic Atrophy ◽  
Optical Coherence ◽  
Tomography Finding

Improving Interpretability in Machine Diagnosis: Detection of Geographic Atrophy in Optical Coherence Tomography Scans

2021 ◽  
pp. 100038
Author(s):  
Xiaoshuang Shi ◽  
Tiarnan D.L. Keenan ◽  
Qingyu Chen ◽  
Tharindu De Silva ◽  
Alisa T. Thavikulwat ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Geographic Atrophy ◽  
Optical Coherence

scholarly journals Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Characteristics in a Rapidly Progressing Form of Geographic Atrophy

2011 ◽  
Vol 52 (6) ◽  
pp. 3761 ◽  
Author(s):  
Monika Fleckenstein ◽  
Steffen Schmitz-Valckenberg ◽  
Christine Martens ◽  
Sebastian Kosanetzky ◽  
Christian K. Brinkmann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fundus Autofluorescence ◽  
Geographic Atrophy ◽  
Spectral Domain ◽  
Optical Coherence

scholarly journals Early Detection of Incipient Retinal Pigment Epithelium Atrophy Overlying Drusen with Fundus Autofluorescence vs. Spectral Domain Optical Coherence Tomography

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Anabel Rodríguez ◽  
Marc Biarnés ◽  
Rosa M. Coco-Martin ◽  
Anna Sala-Puigdollers ◽  
Jordi Monés
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Pigment Epithelium ◽  
Median Time ◽  
Pigment Epithelium ◽  
Fundus Autofluorescence ◽  
Retinal Pigment ◽  
Geographic Atrophy ◽  
Optical Coherence ◽  
Rpe Atrophy ◽  
Sd Oct

Purpose. This study aims to find out which tool, fundus autofluorescence (FAF) or spectral domain optical coherence tomography (SD-OCT), is more sensitive in detecting retinal pigment epithelium (RPE) demise overlying drusen and can, therefore, help predict geographic atrophy (GA) appearance in Age-Related Macular Degeneration (AMD). Methods. A single-site, retrospective, observational, longitudinal study was conducted. Patients with intermediate AMD (iAMD) (large (>125 μm) or intermediate (63–125 μm) drusen with hyper/hypopigmentation) with a minimum follow-up of 18 months were included. Drusen with overlying incipient RPE atrophy were identified on SD-OCT defined as choroidal hypertransmission or nascent geographic atrophy (nGA). These selected drusen were, then, traced backwards in time to determine if incipient RPE atrophy overlying drusen was observed on FAF (well-demarcated region of absence of autofluorescence) before, simultaneously, or after having detected the first signs of incipient RPE atrophy on SD-OCT. The number of drusen in which signs of incipient RPE atrophy was detected earlier using FAF or SD-OCT was compared. The time elapsed from the identification with the more sensitive method to the other was recorded and analyzed. Results. One hundred and thirty-three drusen in 22 eyes of 22 patients were included. Of these, 112 (84.2%) drusen showed choroidal hypertransmission and 21(15.8%) nGA. Early signs of atrophy overlying drusen were found simultaneously on SD-OCT and FAF in 52 cases (39.1%, 95% CI 30.8–47.9%), earliest on FAF in 51 (38.3%, 95% CI 30.0–47.2%) and first on SD-OCT in 30 (22.6%, 95% CI 15.8–30.6%; p<0.05). Statistically significant differences were found between both techniques (p=0.005), with FAF detecting it earlier than SD-OCT. When RPE atrophy was found first on FAF, the median time to diagnosis with SD-OCT was 6.6 months (95% CI 5.5 to 8.6), while if detection occurred earlier on SD-OCT, the median time until identification with FAF was 12.6 months (95% CI 6.0 to 23.4; p=0.0003). Conclusions. In iAMD cases in which early atrophy overlying drusen is not detected simultaneously in FAF and SD-OCT, FAF was significantly more sensitive. Nevertheless, a multimodal approach is recommended and required to evaluate these patients.

CLASSIFICATION AND QUANTITATIVE ANALYSIS OF GEOGRAPHIC ATROPHY JUNCTIONAL ZONE USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

Retina ◽  
2018 ◽  
Vol 38 (8) ◽  
pp. 1456-1463 ◽  
Author(s):  
Jinfeng Qu ◽  
Swetha Bindu Velaga ◽  
Amir H. Hariri ◽  
Muneeswar Gupta Nittala ◽  
Srinivas Sadda
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Analysis ◽  
Geographic Atrophy ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Junctional Zone
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