Effect of the Rho Kinase Inhibitor Y-27632 on Corneal Endothelial Wound Healing

2015 ◽  
Vol 56 (10) ◽  
pp. 6067 ◽  
Author(s):  
Naoki Okumura ◽  
Ryota Inoue ◽  
Yugo Okazaki ◽  
Shinichiro Nakano ◽  
Hiroko Nakagawa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Rho Kinase Inhibitor ◽  
Endothelial Wound Healing

A RHO kinase inhibitor, AMA0526 improves corneal wound healing after alkali burn injury

2013 ◽  
Vol 91 ◽  
pp. 0-0
Author(s):  
D SIJNAVE ◽  
K HOLLANDERS ◽  
T VAN BERGEN ◽  
S VAN DE VELDE ◽  
E VANDEWALLE ◽  
...  
Keyword(s):  
Wound Healing ◽  
Kinase Inhibitor ◽  
Burn Injury ◽  
Rho Kinase ◽  
Corneal Wound Healing ◽  
Alkali Burn ◽  
Rho Kinase Inhibitor ◽  
Corneal Wound

scholarly journals Rho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Aβ transfer receptor expression in mouse brain microvessels

2021 ◽  
Vol 476 (5) ◽  
pp. 2159-2170
Author(s):  
Qiangtang Chen ◽  
Yu Wu ◽  
Yachun Yu ◽  
Junxiang Wei ◽  
Wen Huang
Keyword(s):  
Tight Junction ◽  
Signaling Pathway ◽  
Mouse Brain ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Receptor Expression ◽  
Mrna Levels ◽  
Brain Microvessels ◽  
Rho Kinase Inhibitor ◽  
Hiv 1

AbstractHIV-1 transactivator protein (Tat) induces tight junction (TJ) dysfunction and amyloid-beta (Aβ) clearance dysfunction, contributing to the development and progression of HIV-1-associated neurocognitive disorder (HAND). The Rho/ROCK signaling pathway has protective effects on neurodegenerative disease. However, the underlying mechanisms of whether Rho/ROCK protects against HIV-1 Tat-caused dysfunction of TJ and neprilysin (NEP)/Aβ transfer receptor expression have not been elucidated. C57BL/6 mice were administered sterile saline (i.p., 100 μL) or Rho-kinase inhibitor hydroxyfasudil (HF) (i.p., 10 mg/kg) or HIV-1 Tat (i.v., 100 μg/kg) or HF 30 min before being exposed to HIV-1 Tat once a day for seven consecutive days. Evans Blue (EB) leakage was detected via spectrophotometer and brain slides in mouse brains. The protein and mRNA levels of zonula occludens-1 (ZO-1), occludin, NEP, receptor for advanced glycation end products (RAGE), and low-density lipoprotein receptor-related protein 1 (LRP1) in mouse brain microvessels were, respectively, analyzed by Western blotting and quantitative real-time polymerase chain reaction (qRT-PCR) analyses. Exposure of the mice to HIV-1 Tat increased the amount of EB leakage, EB fluorescence intensity, blood–brain barrier (BBB) permeability, as well as the RAGE protein and mRNA levels, and decreased the protein and mRNA levels of ZO-1, occludin, NEP, and LRP1 in mouse brain microvessels. However, these effects were weakened by Rho-kinase inhibitor HF. Taken together, these results provide information that the Rho/ROCK signaling pathway is involved in HIV-1 Tat-induced dysfunction of TJ and NEP/Aβ transfer receptor expression in the C57BL/6 mouse brain. These findings shed some light on potentiality of inhibiting Rho/Rock signaling pathway in handling HAND.

Rho kinase inhibitor for primary open-angle glaucoma and ocular hypertension

2020 ◽  
Author(s):  
Josefine Clement Freiberg ◽  
Alexander von Spreckelsen ◽  
Naira Khachatryan ◽  
Miriam Kolko ◽  
Augusto Azuara-Blanco ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Kinase Inhibitor ◽  
Open Angle Glaucoma ◽  
Rho Kinase ◽  
Open Angle ◽  
Rho Kinase Inhibitor

Protective effect of hydroxyfasudil, a Rho kinase inhibitor, on ventral prostatic hyperplasia in the spontaneously hypertensive rat

The Prostate ◽  
2015 ◽  
Vol 75 (15) ◽  
pp. 1774-1782 ◽  
Author(s):  
Felix Holmström ◽  
Shogo Shimizu ◽  
Takahiro Shimizu ◽  
Youichirou Higashi ◽  
Darryl T. Martin ◽  
...  
Keyword(s):  
Protective Effect ◽  
Kinase Inhibitor ◽  
Spontaneously Hypertensive Rat ◽  
Rho Kinase ◽  
Prostatic Hyperplasia ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Rho Kinase Inhibitor
Sign in / Sign up

Export Citation Format

Share Document