scholarly journals Finite Element Modeling of Factors Influencing Optic Nerve Head Deformation Due to Intracranial Pressure

2016 ◽  
Vol 57 (4) ◽  
pp. 1901 ◽  
Author(s):  
Andrew J. Feola ◽  
Jerry G. Myers ◽  
Julia Raykin ◽  
Lealem Mulugeta ◽  
Emily S. Nelson ◽  
...  
Keyword(s):  
Finite Element ◽  
Optic Nerve ◽  
Intracranial Pressure ◽  
Finite Element Modeling ◽  
Optic Nerve Head ◽  
Element Modeling ◽  
Factors Influencing

Finite Element Modeling of Optic Nerve Head Biomechanics

2004 ◽  
Vol 45 (12) ◽  
pp. 4378 ◽  
Author(s):  
Ian A. Sigal ◽  
John G. Flanagan ◽  
Inka Tertinegg ◽  
C. Ross Ethier
Keyword(s):  
Finite Element ◽  
Optic Nerve ◽  
Finite Element Modeling ◽  
Optic Nerve Head ◽  
Element Modeling

Finite element modeling of the human sclera: Influence on optic nerve head biomechanics and connections with glaucoma

2011 ◽  
Vol 93 (1) ◽  
pp. 4-12 ◽  
Author(s):  
Richard E. Norman ◽  
John G. Flanagan ◽  
Ian A. Sigal ◽  
Sophie M.K. Rausch ◽  
Inka Tertinegg ◽  
...  
Keyword(s):  
Finite Element ◽  
Optic Nerve ◽  
Finite Element Modeling ◽  
Optic Nerve Head ◽  
Element Modeling

scholarly journals Assessment of the Viscoelastic Mechanical Properties of the Porcine Optic Nerve Head using Micromechanical Testing and Finite Element Modeling

2021 ◽  
Author(s):  
Babak N. Safa ◽  
A. Thomas Read ◽  
C. Ross Ethier
Keyword(s):  
Mechanical Properties ◽  
Finite Element ◽  
Optic Nerve ◽  
Finite Element Modeling ◽  
Optic Nerve Head ◽  
Mechanical Response ◽  
Solid Matrix ◽  
Hydraulic Permeability ◽  
Element Modeling ◽  
Micromechanical Testing

AbstractOptic nerve head (ONH) biomechanics is centrally involved in the pathogenesis of glaucoma, a blinding ocular condition often characterized by elevation and fluctuation of the intraocular pressure and resulting loads on the ONH. Further, tissue viscoelasticity is expected to strongly influence the mechanical response of the ONH to mechanical loading, yet the viscoelastic mechanical properties of the ONH remain unknown. To determine these properties, we conducted micromechanical testing on porcine ONH tissue samples, coupled with finite element modeling based on a mixture model consisting of a biphasic material with a viscoelastic solid matrix. Our results provide a detailed description of the viscoelastic properties of the porcine ONH at each of its four anatomical quadrants (i.e., nasal, superior, temporal, and inferior). We showed that the ONH’s viscoelastic mechanical response can be explained by a dual mechanism of fluid flow and solid matrix viscoelasticity, as is common in other soft tissues. We obtained porcine ONH properties as follows: matrix Young’s modulus E=1.895 [1.056,2 .391] kPa (median [min., max.]), Poisson’s ratio ν=0.142 [0.060,0 .312], kinetic time-constant τ=214 [89,921] sec, and hydraulic permeability k=3.854 × 10−1 [3.457 × 10−2,9.994 × 10−1] mm4/(N sec). These values can be used to design and fabricate physiologically appropriate ex vivo test environments (e.g., 3D cell culture) to further understand glaucoma pathophysiology.

Finite Element Modeling of the Connective Tissues of the Optic Nerve Head in Bilaterally Normal Monkeys

2009 ◽  
Author(s):  
Michael D. Roberts ◽  
Ian A. Sigal ◽  
Yi Liang ◽  
Claude F. Burgoyne ◽  
J. Crawford Downs
Keyword(s):  
Finite Element ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Finite Element Modeling ◽  
Optic Neuropathy ◽  
Optic Nerve Head ◽  
Connective Tissues ◽  
Element Modeling ◽  
Field Of Vision

Glaucoma is a chronic and progressive optic neuropathy that gradually narrows the field of vision and can culminate in blindness. Despite extensive and prolonged research efforts, the mechanisms that initiate and fuel progression of the disease are not well understood. However, reduction of intraocular pressure (IOP) has been shown to be an effective therapy for slowing glaucomatous progression, although the specific role of IOP in the disease is not well understood.

Continuum-level finite element modeling of the optic nerve head

2006 ◽  
Vol 39 ◽  
pp. S385
Author(s):  
M.D. Roberts ◽  
R.T. Hart ◽  
C.F. Burgoyne ◽  
J.C. Downs
Keyword(s):  
Finite Element ◽  
Optic Nerve ◽  
Finite Element Modeling ◽  
Optic Nerve Head ◽  
Element Modeling
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