scholarly journals The Photopic Negative Response in Idiopathic Intracranial Hypertension

2015 ◽  
Vol 56 (6) ◽  
pp. 3709 ◽  
Author(s):  
Heather E. Moss ◽  
Jason C. Park ◽  
J. Jason McAnany
Keyword(s):  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Negative Response ◽  
Photopic Negative Response

scholarly journals Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device

Life ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 437
Author(s):  
Antony Raharja ◽  
Shaun M. Leo ◽  
Isabelle Chow ◽  
Mathura Indusegaran ◽  
Christopher J. Hammond ◽  
...  
Keyword(s):  
Intracranial Hypertension ◽  
Disease Severity ◽  
Idiopathic Intracranial Hypertension ◽  
Retinal Nerve Fibre Layer ◽  
Negative Response ◽  
Photopic Negative Response ◽  
Mean Deviation ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Handheld Device

The photopic negative response (PhNR) is a negative component of the photopic flash electroretinogram that follows the b-wave and is thought to arise from the retinal ganglion cells. Reduction in its amplitude in idiopathic intracranial hypertension (IIH) has been previously documented using formal electroretinography. This study explored the use of a handheld device (RETeval, LKC technologies, USA) in 72 IIH patients of varying stages and severity (and seven controls) and investigated associations between PhNR parameters and disease severity. PhNR amplitudes at 72ms (P72) and p-ratio (ratio to b-wave peak value) differed significantly across groups, with a trend towards smaller amplitudes in those with severe IIH, defined as papilloedema with Modified Frisén Scale (MFS) ≥ 3, retinal nerve fibre layer (RNFL) ≥ 150μm or atrophic papilloedema (p = 0.0048 and p = 0.018 for P72 and p-ratio, respectively). PhNR parameters did not correlate with MFS, RNFL thickness, standard automated perimetry mean deviation or macular ganglion cell layer volume. This study suggests that PhNR measurement using a handheld device is feasible and could potentially augment the assessment of disease severity in IIH. The clinical utility of PhNR monitoring in IIH patients requires further investigation.

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