scholarly journals In Vivo Confocal Microscopy Demonstrates Bilateral Loss of Endothelial Cells in Unilateral Herpes Simplex Keratitis

2015 ◽  
Vol 56 (8) ◽  
pp. 4899 ◽  
Author(s):  
Rodrigo T. Müller ◽  
Roxanna Pourmirzaie ◽  
Deborah Pavan-Langston ◽  
Bernardo M. Cavalcanti ◽  
Shruti Aggarwal ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Herpes Simplex ◽  
Confocal Microscopy ◽  
In Vivo Confocal Microscopy ◽  
Herpes Simplex Keratitis

scholarly journals Corneal nerve regeneration after herpes simplex keratitis: A longitudinal in vivo confocal microscopy study

2018 ◽  
Vol 16 (2) ◽  
pp. 218-225 ◽  
Author(s):  
Hamid-Reza Moein ◽  
Ahmad Kheirkhah ◽  
Rodrigo T. Muller ◽  
Andrea C. Cruzat ◽  
Deborah Pavan-Langston ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Confocal Microscopy ◽  
Nerve Regeneration ◽  
Microscopy Study ◽  
In Vivo Confocal Microscopy ◽  
Corneal Nerve ◽  
Herpes Simplex Keratitis

Effect of herpes simplex keratitis scar location on bilateral corneal nerve alterations: an in vivo confocal microscopy study

2020 ◽  
pp. bjophthalmol-2020-316628
Author(s):  
Chareenun Chirapapaisan ◽  
Rodrigo T. Muller ◽  
Afsun Sahin ◽  
Andrea Cruzat ◽  
Bernardo M. Cavalcanti ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Confocal Microscopy ◽  
Peripheral Nerves ◽  
In Vivo Confocal Microscopy ◽  
Corneal Sensation ◽  
Scar Area ◽  
Corneal Nerve ◽  
The Impact ◽  
Peripheral Cornea

AimsTo evaluate the impact of herpes simplex virus (HSV)-induced scar location on bilateral corneal nerve alterations using laser in vivo confocal microscopy (IVCM).MethodsCentral and peripheral corneal subbasal nerve density (CSND) were assessed bilaterally in 39 patients with unilateral HSV-induced corneal scars (21 central scars (CS), 18 peripheral scars (PS)) using IVCM. Results were compared between patients and 24 age-matched controls. CSND was correlated to corneal sensation for all locations.ResultsOverall patients revealed significant decrease of CSND in the central and peripheral cornea (9.13±0.98 and 6.26±0.53 mm/mm2, p<0.001), compared with controls (22.60±0.77 and 9.88±0.49 mm/mm2). CS group showed a decrease in central (8.09±1.30 mm/mm2) and total peripheral nerves (5.15±0.62 mm/mm2) of the affected eyes, whereas PS group demonstrated a decrease in central (10.34±1.48 mm/mm2) and localised peripheral nerves only in the scar area (4.22±0.77 mm/mm2) (all p<0.001). In contralateral eyes, CSND decreased in the central cornea of the CS group (16.88±1.27, p=0.004), and in the peripheral area, mirroring the scar area in the affected eyes of the PS group (7.20±0.87, p=0.032). Corneal sensation significantly decreased in the whole cornea of the affected, but not in contralateral eyes (p<0.001). A positive correlation between CSND and corneal sensation was found in all locations (p<0.001).ConclusionsPatients with HSV scar demonstrate bilateral CSND decrease as shown by IVCM. CSND and corneal sensation decrease in both central and peripheral cornea in affected eyes, although only in the scar area in PS group. Interestingly, diminishment of CSND was found locally in the contralateral eyes, corresponding and mirroring the scar location in the affected eyes.

Endothelial Involvement in Herpes Simplex Virus Keratitis: An In Vivo Confocal Microscopy Study

Ophthalmology ◽  
2009 ◽  
Vol 116 (11) ◽  
pp. 2077-2086.e2 ◽  
Author(s):  
Toine Hillenaar ◽  
Christien Weenen ◽  
René J. Wubbels ◽  
Lies Remeijer
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Confocal Microscopy ◽  
Microscopy Study ◽  
In Vivo Confocal Microscopy ◽  
Simplex Virus
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