Photophobia and Corneal Crystal Density in Nephropathic Cystinosis: An In Vivo Confocal Microscopy and Anterior-Segment Optical Coherence Tomography Study

2015 ◽  
Vol 56 (5) ◽  
pp. 3218 ◽  
Author(s):  
Hong Liang ◽  
Christophe Baudouin ◽  
Rachid Tahiri Joutei Hassani ◽  
Françoise Brignole-Baudouin ◽  
Antoine Labbe
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Nephropathic Cystinosis ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Crystal Density

scholarly journals Examination of corneal deposits in nephropathic cystinosis using in vivo confocal microscopy and anterior segment optical coherence tomography: an age-dependent cross sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Anita Csorba ◽  
Erika Maka ◽  
Otto Alexander Maneschg ◽  
Attila Szabó ◽  
Nóra Szentmáry ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Interquartile Range ◽  
Nephropathic Cystinosis ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Crystal Deposition ◽  
Crystal Density

Abstract Background Presence of corneal cystine crystals is the main ocular manifestation of cystinosis, although controversial findings concerning the corneal layer with the highest density have been reported. The aim of this study was the analysis of the characteristics of crystal arrangement in different corneal layers and the assessment of corneal morphological changes with age. Methods A cross sectional study was carried out in three children and three adults who had nephropathic cystinosis and corneal cystine depositions. All patients underwent a comprehensive ophthalmological examination including best corrected distance visual acuity, slit-lamp examination, in vivo confocal microscopy and anterior segment optical coherence tomography. An evaluation of the depth of crystal deposits and crystal density in different corneal layers was also performed. Due to the low number of subjects no statistical comparison was performed. Results Anterior segment optical coherence tomography images revealed deposition of hyperreflective crystals from limbus to limbus in each patient. Crystals appeared as randomly oriented hyperreflective, elongated structures on in vivo confocal microscopy images in all corneal layers except the endothelium. In children the deposits occurred predominantly in the anterior stroma, while in adults, the crystals were mostly localized in the posterior corneal stroma with the depth of crystal deposition showing an increasing tendency with age (mean depth of crystal density was 353.17 ± 49.23 μm in children and it was 555.75 ± 25.27 μm in adults). Mean crystal density of the epithelium was 1.47 ± 1.17 (median: 1.5; interquartile range: 0.3–2.4). Mean crystal density of the anterior and posterior stroma of children and adults was 3.37 ± 0.34 (median: 3.4; interquartile range: 3.25–3.55) vs. 1.23 ± 0.23 (median: 1.2; interquartile range: 1.05–1.35) and 0.76 ± 0.49 (median: 0.7; interquartile range: 0.4–1.15) vs. 3.63 ± 0.29 (median: 3.7; interquartile range: 3.45–3.8), respectively. Endothelium had intact structure in all cases. Some hexagonal crystals were observed in two subjects. Conclusions In vivo confocal microscopy and anterior segment optical coherence tomography confirmed an age-related pattern of crystal deposition. In children, crystals tend to locate anteriorly, while in adults, deposits are found posteriorly in corneal stroma.

In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography Analysis of the Cornea in Nephropathic Cystinosis

Ophthalmology ◽  
2009 ◽  
Vol 116 (5) ◽  
pp. 870-876 ◽  
Author(s):  
Antoine Labbé ◽  
Patrick Niaudet ◽  
Chantal Loirat ◽  
Marina Charbit ◽  
Geneviève Guest ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Nephropathic Cystinosis ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Tomography Analysis

Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography

Cornea ◽  
2018 ◽  
Vol 37 (6) ◽  
pp. 785-788
Author(s):  
Aleksandra Petrovic ◽  
Kattayoon Hashemi ◽  
Frank Blaser ◽  
Wolfgang Wild ◽  
George Kymionis
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Interstitial Keratitis

Clinical and morphological manifestations of aniridia-associated keratopathy on anterior segment optical coherence tomography and in vivo confocal microscopy

2017 ◽  
Vol 15 (4) ◽  
pp. 759-769 ◽  
Author(s):  
Anna Voskresenskaya ◽  
Nadezhda Pozdeyeva ◽  
Tatyana Vasilyeva ◽  
Yevgeniy Batkov ◽  
Aleksandr Shipunov ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy

In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography in a Case of Alternaria Keratitis

Cornea ◽  
2011 ◽  
Vol 30 (4) ◽  
pp. 449-453 ◽  
Author(s):  
Gianluca Martone ◽  
Patrizia Pichierri ◽  
Rossella Franceschini ◽  
Antonio Moramarco ◽  
Leonardo Ciompi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy
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