MicroRNA Expression Profile and the Role of miR-204 in Corneal Wound Healing

2015 ◽  
Vol 56 (6) ◽  
pp. 3673 ◽  
Author(s):  
Jianhong An ◽  
Xiaoyan Chen ◽  
Weiwei Chen ◽  
Rongxin Liang ◽  
Peter S. Reinach ◽  
...  
Keyword(s):  
Wound Healing ◽  
Expression Profile ◽  
Microrna Expression ◽  
Corneal Wound Healing ◽  
Microrna Expression Profile ◽  
Corneal Wound

scholarly journals The Role of Neutrophils in Corneal Wound Healing in HO-2 Null Mice

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e21180 ◽  
Author(s):  
Giuseppina Marrazzo ◽  
Lars Bellner ◽  
Adna Halilovic ◽  
Giovanni Li Volti ◽  
Filippo Drago ◽  
...  
Keyword(s):  
Wound Healing ◽  
Corneal Wound Healing ◽  
Corneal Wound

scholarly journals Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Kyu-Yeon Han ◽  
Jennifer A. Tran ◽  
Jin-Hong Chang ◽  
Dimitri T. Azar ◽  
James D. Zieske
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Potential Role ◽  
Corneal Epithelial Cell ◽  
Corneal Wound Healing ◽  
Corneal Epithelial ◽  
Corneal Wound

The Role of Extracellular Matrix in Corneal Wound Healing

Cornea ◽  
2013 ◽  
Vol 32 ◽  
pp. S43-S45 ◽  
Author(s):  
Osamu Yamanaka ◽  
Takayoshi Sumioka ◽  
Shizuya Saika
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Corneal Wound Healing ◽  
Corneal Wound

Characterization and predicted role of the microRNA expression profile in amnion from obese pregnant women

2013 ◽  
Vol 38 (3) ◽  
pp. 466-469 ◽  
Author(s):  
C Nardelli ◽  
L Iaffaldano ◽  
M Ferrigno ◽  
G Labruna ◽  
G M Maruotti ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Expression Profile ◽  
Microrna Expression ◽  
Microrna Expression Profile

scholarly journals Role of VIP and Sonic Hedgehog signaling pathways in mediating epithelial wound healing, sensory nerve regeneration and their defects in diabetic corneas

2020 ◽  
Author(s):  
Ada Admin ◽  
Yangyang Zhang ◽  
Nan Gao ◽  
Lin Wu ◽  
Patrick S. Y. Lee ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Regeneration ◽  
Sonic Hedgehog ◽  
Sensory Nerve ◽  
Dependent Manner ◽  
Corneal Wound Healing ◽  
Epithelial Wound Healing ◽  
Corneal Wound ◽  
Diabetic Keratopathy

Diabetic Keratopathy, a sight-threatening corneal disease, comprises several symptomatic conditions including delayed epithelial wound healing, recurrent erosions, and sensory nerve (SN) neuropathy. We investigated the role of neuropeptides in mediating corneal wound healing, including epithelial wound closure and SN regeneration. Denervation by Resiniferatoxin severely impaired corneal wound healing and markedly up-regulated pro-inflammatory gene expression. Exogenous neuropeptides CGRP, SP, and VIP partially reversed Resiniferatoxin’s effects, with VIP specifically inducing IL-10 expression. Hence, we focused on VIP and observed that wounding induced VIP and VIPR1 expression in normal (NL), but not diabetic (DM) mouse corneas. Targeting VIPR1 in <em>NL</em> corneas attenuated corneal wound healing, dampened wound-induced expression of neurotrophic factors, and exacerbated inflammatory responses while exogenous VIP had the opposite effects in DM corneas. Remarkably, wounding and diabetes also affected the expression of Sonic Hedgehog (SHH) in a VIP-dependent manner. Downregulating SHH expression in NL corneas decreased, while exogenous SHH in DM corneas increased the rates of corneal wound healing. Furthermore, inhibition of SHH signaling dampened VIP-promoted corneal wound healing. We conclude that VIP regulates epithelial wound he<a></a><a>aling, inflammatory response, and nerve regeneration in the corneas in a</a> SHH-dependent manner, suggesting a therapeutic potential for these molecules in treating diabetic keratopathy.

scholarly journals Diagnostic Role of MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome

2018 ◽  
Vol 35 (2) ◽  
pp. 163-166 ◽  
Author(s):  
Emin Karaca ◽  
Ayça Aykut ◽  
Biray Ertürk ◽  
Burak Durmaz ◽  
Ahmet Güler ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Expression Profile ◽  
Microrna Expression ◽  
Microrna Expression Profile ◽  
Diagnostic Role

scholarly journals The role of hepatocyte growth factor in corneal wound healing

2018 ◽  
Vol 166 ◽  
pp. 49-55 ◽  
Author(s):  
Hidetaka Miyagi ◽  
Sara M. Thomasy ◽  
Paul Russell ◽  
Christopher J. Murphy
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Corneal Wound Healing ◽  
Corneal Wound ◽  
Hepatocyte Growth

MicroRNA expression profile in bovine cumulus–oocyte complexes: Possible role of let-7 and miR-106a in the development of bovine oocytes

2012 ◽  
Vol 130 (1-2) ◽  
pp. 16-26 ◽  
Author(s):  
J.R. Miles ◽  
T.G. McDaneld ◽  
R.T. Wiedmann ◽  
R.A. Cushman ◽  
S.E. Echternkamp ◽  
...  
Keyword(s):  
Expression Profile ◽  
Microrna Expression ◽  
Microrna Expression Profile ◽  
Bovine Oocytes
Sign in / Sign up

Export Citation Format

Share Document