Networks of Genes Governing the Development of Optic and Otic Vesicles: Implications for Eye and Ear Development

2015 ◽  
Vol 56 (2) ◽  
pp. 892-892
Author(s):  
M. M. Abitbol
Keyword(s):  
Ear Development ◽  
Otic Vesicles

Comparative analysis of conservation and regulatory network on core transcription factors in mouse inner ear development

2013 ◽  
Vol 35 (10) ◽  
pp. 1198-1208
Author(s):  
Zhi-Qiang CHEN ◽  
Xin-Huan HAN ◽  
Qin-Jun WEI ◽  
Guang-Qian XING ◽  
Xin CAO
Keyword(s):  
Transcription Factors ◽  
Comparative Analysis ◽  
Inner Ear ◽  
Regulatory Network ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice

2009 ◽  
Vol 328 (2) ◽  
pp. 328-341 ◽  
Author(s):  
Garrett A. Soukup ◽  
Bernd Fritzsch ◽  
Marsha L. Pierce ◽  
Michael D. Weston ◽  
Israt Jahan ◽  
...  
Keyword(s):  
Inner Ear ◽  
Knockout Mice ◽  
Microrna Expression ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals Role of microRNAs in inner ear development and hearing loss

Gene ◽  
2019 ◽  
Vol 686 ◽  
pp. 49-55 ◽  
Author(s):  
Rahul Mittal ◽  
George Liu ◽  
Sai P. Polineni ◽  
Nicole Bencie ◽  
Denise Yan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals Scanning thin-sheet laser imaging microscopy elucidates details on mouse ear development

2013 ◽  
Vol 242 (5) ◽  
pp. 591-592
Author(s):  
Benjamin Kopecky ◽  
Shane Johnson ◽  
Heather Schmitz ◽  
Peter Santi ◽  
Bernd Fritzsch
Keyword(s):  
Thin Sheet ◽  
Laser Imaging ◽  
Ear Development ◽  
Mouse Ear

The tabby syndrome in the mouse

1971 ◽  
Vol 179 (1055) ◽  
pp. 139-156 ◽  
Keyword(s):  
Critical Point ◽  
X Chromosome ◽  
Neural Tube ◽  
X Chromosome Inactivation ◽  
Cellular Level ◽  
Normal Allele ◽  
Linked Gene ◽  
Intercellular Interactions ◽  
Threshold Mechanism ◽  
Otic Vesicles

The tabby syndrome in the mouse (which is common to the sex-linked gene for tabby and autosomal genes for crinkled and downless) affects the coat, the sinus hairs, the teeth, many glands and some surface features like tail rings, plicae digitales and the papilla vallata of the tongue. All these structures develop by the downgrowth of solid epithelial buds into the underlying mesenchyme. Organs which arise by invagination (like the neural tube or the otic vesicles and certain glands) are not affected by the tabby syndrome. The rudiments of glands and sinus hairs are reduced in size, and if reduction goes beyond a critical point, stunted organs are formed or, more commonly, the rudiments regress altogether. The same is true for the teeth and apparently for the whole syndrome. Measurements show the same situation in Ta ♂♂(and Ta/Ta ♀♀) and in heterozygous Ta / + ♀♀. As in Ta ♂♂ and Ta/Ta ♀♀ there cannot be any doubt that a threshold mechanism is involved, there is no reason to assume that, in Ta / + ♀♀, the identical defects are derived clonally from ancestral cells in which the Xchromosome carrying the normal allele has been inactivated. Whereas the Ta / + phenotype does not give any evidence that the Ta locus is involved in X-chromosome inactivation, the possibility cannot be ruled out that, if inactivation should actually take place on the cellular level, the macroscopic phenotype could be the result of intercellular interactions along with the effects of threshold mechanisms.

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