scholarly journals Role of Bax in Death of Uninfected Retinal Cells During Murine Cytomegalovirus Retinitis

2014 ◽  
Vol 55 (11) ◽  
pp. 7137 ◽  
Author(s):  
Juan Mo ◽  
Brendan Marshall ◽  
Jason Covar ◽  
Nancy Y. Zhang ◽  
Sylvia B. Smith ◽  
...  
Keyword(s):  
Cytomegalovirus Retinitis ◽  
Murine Cytomegalovirus ◽  
Retinal Cells

scholarly journals Murine Cytomegalovirus CC Chemokine Homolog MCK-2 (m131-129) Is a Determinant of Dissemination That Increases Inflammation at Initial Sites of Infection

2001 ◽  
Vol 75 (20) ◽  
pp. 9966-9976 ◽  
Author(s):  
Noah Saederup ◽  
Shirley A. Aguirre ◽  
Timothy E. Sparer ◽  
Donna M. Bouley ◽  
Edward S. Mocarski
Keyword(s):  
Salivary Glands ◽  
Primary Infection ◽  
Important Determinant ◽  
Murine Cytomegalovirus ◽  
Viral Dissemination ◽  
Cc Chemokine ◽  
Inoculation Site

ABSTRACT The murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is an important determinant of dissemination during primary infection. Reduced peak levels of viremia at day 5 were followed by reduced levels of virus in salivary glands starting at day 7 when mckinsertion (RM461) and point (RM4511) mutants were compared tomck-expressing viruses. A dramatic MCK-2-enhanced inflammation occurred at the inoculation site over the first few days of infection, preceding viremia. The data further reinforce the role of MCK-2 as a proinflammatory signal that recruits leukocytes to increase the efficiency of viral dissemination in the host.

The role of intraocular f luid polymerase chain reaction in the diagnosis, treatment and monitoring of cytomegalovirus retinitis

2021 ◽  
pp. 380-383
Author(s):  
B.S. Pershin ◽  
◽  
A.A. Maschan ◽  
V.Y. Makhmutov ◽  
M.A. Ilushina ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Stem Cell ◽  
Retinal Detachment ◽  
Cytomegalovirus Retinitis ◽  
Chain Reaction ◽  
Hematopoietic Stem ◽  
Key Words Cytomegalovirus ◽  
Polymerase Chain ◽  
Intraocular Fluid

Purpose. To study the possibilities of a new method of CMRR treatment in the prevention of irreversible blindness. Material and methods. 74 patients with cytomegalovirus retinitis, frolicking after hematopoietic stem cell transplantation. The first group (9 people, 15 eyes) consisted of children, whose treatment was carried out under ophthalmoscopic control. The second group (65 people, 114 eyes) consisted of children in whom the control of the effectiveness of treatment was carried out using PCR of aqueous humor in real time. Results. In the first group, retinal detachment was diagnosed in three out of fifteen eyes, accounting for 20%. In the second group, the incidence of retinal detachment was 3.5% of 114 eyes. Among patients receiving treatment under ophthalmoscopic control, CMRR relapses were detected in 5 cases, which amounted to 33.3%. In children, whose treatment was controlled by intraocular fluid PCR, relapses were diagnosed in 22 cases, which amounted to 19.29%. Conclusions. Intravitreal administration of antiviral drugs under the control of polymerase chain reaction is a more effective method of treating cytomegalovirus retinitis than intravitreal administration under ophthalmoscopic control. Key words: cytomegalovirus retinitis, intraocular fluid polymerase chain reaction.

Mechanisms of AIDS-related cytomegalovirus retinitis

2019 ◽  
Vol 14 (8) ◽  
pp. 545-560 ◽  
Author(s):  
Jessica Carter ◽  
Christine I Alston ◽  
Jay Oh ◽  
Lauren-Ashley Duncan ◽  
Judee Grace Esquibel Nemeno ◽  
...  
Keyword(s):  
Mouse Model ◽  
Human Cytomegalovirus ◽  
Human Disease ◽  
Cytomegalovirus Retinitis ◽  
Murine Cytomegalovirus ◽  
Opportunistic Pathogens ◽  
Aids Patients ◽  
Clinical Burden ◽  
Antiretroviral Therapies ◽  
Murine Aids

Human cytomegalovirus (HCMV) generates a significant clinical burden worldwide, particularly among the immune compromised. In approximately 30% of untreated HIV/AIDS patients without access or sufficient response to antiretroviral therapies, for example, HCMV causes a sight-threatening retinitis. To study the mechanisms of AIDS-related HCMV retinitis, our lab has for many years used a mouse model in which a mixture of mouse retroviruses induces murine AIDS after approximately 10 weeks, rendering otherwise resistant mice susceptible to opportunistic pathogens. This immunodeficiency combined with subretinal inoculation of murine cytomegalovirus yields a reproducible model of the human disease, facilitating the discovery of many clinically relevant virologic and immunologic mechanisms of retinal destruction which we summarize in this review.

Role of human cytomegalovirus genotype polymorphisms in AIDS patients with cytomegalovirus retinitis

2012 ◽  
Vol 202 (1) ◽  
pp. 37-47 ◽  
Author(s):  
Jens-Uwe Vogel ◽  
Jürgen Otte ◽  
Frank Koch ◽  
Hermann Gümbel ◽  
Hans Wilhelm Doerr ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Cytomegalovirus Retinitis ◽  
Aids Patients

scholarly journals The Role of NKG2D Signaling in Inhibition of Cytotoxic T-Lymphocyte Lysis by the Murine Cytomegalovirus Immunoevasin m152/gp40

2007 ◽  
Vol 81 (22) ◽  
pp. 12564-12571 ◽  
Author(s):  
Amelia K. Pinto ◽  
Amanda M. Jamieson ◽  
David H. Raulet ◽  
Ann B. Hill
Keyword(s):  
Mhc Class I ◽  
Cytotoxic T Lymphocyte ◽  
Class I ◽  
Murine Cytomegalovirus ◽  
Small Subset ◽  
Small Contribution ◽  
Nkg2d Ligands ◽  
Infected Cells ◽  
The Impact

ABSTRACT Three proteins encoded by murine cytomegalovirus (MCMV)— gp34, encoded by m04 (m04/gp34), gp48, encoded by m06 (m06/gp48), and gp40, encoded by m152 (m152/gp40)—act together to powerfully impact the ability of primed cytotoxic CD8 T lymphocytes (CTL) to kill virus-infected cells. Of these three, the impact of m152/gp40 on CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregulates the RAE-1 family of NKG2D ligands, which can provide costimulation for CD8 T cells. We hypothesized that m152/gp40 may impact CTL lysis so profoundly because it inhibits both antigen presentation and NKG2D-mediated costimulation. We therefore tested the extent to which m152/gp40's ability to inhibit CTL lysis of MCMV-infected cells could be accounted for by its inhibition of NKG2D signaling. As was predictable from the results reported in the literature, NKG2D ligands were not detected by NKG2D tetramer staining of cells infected with wild-type MCMV, whereas those infected with MCMV lacking m152/gp40 displayed measurable levels of the NKG2D ligand. To determine whether NKG2D signaling contributed to the ability of CTL to lyse these cells, we used a blocking anti-NKG2D antibody. Blocking NKG2D signaling did affect the killing of MCMV-infected cells for some epitopes. However, for all epitopes, the impact of m152/gp40 on CTL lysis was much greater than the impact of inhibition of NKG2D signaling. We conclude that the downregulation of NKG2D ligands by MCMV makes only a small contribution to the impact of m152/gp40 on CTL lysis and only for a small subset of CTL.

scholarly journals Cmv1-Independent Antiviral Role of NK Cells Revealed in Murine Cytomegalovirus-Infected New Zealand White Mice

2004 ◽  
Vol 173 (10) ◽  
pp. 6312-6318 ◽  
Author(s):  
Marisela Rodriguez ◽  
Pearl Sabastian ◽  
Patricia Clark ◽  
Michael G. Brown
Keyword(s):  
New Zealand ◽  
Nk Cells ◽  
Murine Cytomegalovirus ◽  
Antiviral Role

scholarly journals Role of the Indigenous Microbiota in Maintaining the Virus-Specific CD8 Memory T Cells in the Lung of Mice Infected with Murine Cytomegalovirus

2007 ◽  
Vol 178 (8) ◽  
pp. 5209-5216 ◽  
Author(s):  
Kazuo Tanaka ◽  
Sadaaki Sawamura ◽  
Tadayuki Satoh ◽  
Kiyoshi Kobayashi ◽  
Satoshi Noda
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Murine Cytomegalovirus ◽  
Indigenous Microbiota ◽  
Cd8 Memory T Cells
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