scholarly journals The Effect of TIMP-1 on the Cone Mosaic in the Retina of the Rat Model of Retinitis Pigmentosa

2014 ◽  
Vol 56 (1) ◽  
pp. 352-364 ◽  
Author(s):  
Y. Ji ◽  
W.-Q. Yu ◽  
Y. S. Eom ◽  
F. Bruce ◽  
C. M. Craft ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Rat Model ◽  
Cone Mosaic

scholarly journals Reshaping the Cone-Mosaic in a Rat Model of Retinitis Pigmentosa: Modulatory Role of ZO-1 Expression in DL-Alpha-Aminoadipic Acid Reshaping

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151668 ◽  
Author(s):  
Wan-Qing Yu ◽  
Yun Sung Eom ◽  
Jung-A Shin ◽  
Divya Nair ◽  
Sara X. Z. Grzywacz ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Rat Model ◽  
Cone Mosaic

Role of Müller cells in cone mosaic rearrangement in a rat model of retinitis pigmentosa

Glia ◽  
2011 ◽  
Vol 59 (7) ◽  
pp. 1107-1117 ◽  
Author(s):  
Eun-Jin Lee ◽  
Yerina Ji ◽  
Colleen L. Zhu ◽  
Norberto M. Grzywacz
Keyword(s):  
Retinitis Pigmentosa ◽  
Rat Model ◽  
Müller Cells ◽  
Muller Cells ◽  
Cone Mosaic

scholarly journals Rearrangement of the cone mosaic in the retina of the rat model of retinitis pigmentosa

2012 ◽  
Vol 520 (4) ◽  
pp. 874-888 ◽  
Author(s):  
Yerina Ji ◽  
Colleen L. Zhu ◽  
Norberto M. Grzywacz ◽  
Eun-Jin Lee
Keyword(s):  
Retinitis Pigmentosa ◽  
Rat Model ◽  
Cone Mosaic

scholarly journals The Effect of Cyanine Dye NK-4 on Photoreceptor Degeneration in a Rat Model of Early-Stage Retinitis Pigmentosa

2021 ◽  
Vol 14 (7) ◽  
pp. 694
Author(s):  
Shihui Liu ◽  
Toshihiko Matsuo ◽  
Mary Miyaji ◽  
Osamu Hosoya
Keyword(s):  
Retinitis Pigmentosa ◽  
Rat Model ◽  
Metal Ion ◽  
Toxic Substance ◽  
Cyanine Dye ◽  
Pathway Enrichment Analysis ◽  
Rna Seq ◽  
Pathway Enrichment ◽  
Metal Ion Homeostasis ◽  
Rcs Rats

The present study aimed to evaluate the effects of NK-4 on the apoptosis of photoreceptors in a rat model of retinitis pigmentosa and explore the mechanism underlying anti-apoptosis activity. The Royal College of Surgeons (RCS) rats received an intravitreous injection of NK-4 solution in the left eye and vehicle control in the right eye. Apoptosis was detected by TUNEL method in frozen sections of the eyes. The retinal tissues of the rats were dissected for RNA-seq analysis. Functional and pathway enrichment analyses of differentially expressed genes (DEGs) were performed by using Metascape and DAVID software. The expression levels of DEGs were confirmed by real-time quantitative PCR (RT-qPCR). The number of apoptotic cells decreased in the outer nuclear layer (ONL) and the thickness of the ONL was significantly thicker in the retina of NK-4-injected eyes, compared with control eyes. Five DEGs were identified by RNA-seq analysis, and Hmox1, Mt1, Atf5, Slc7a11, and Bdh2 were confirmed to be up-regulated by RT-qPCR. Functional and pathway enrichment analysis of the up-regulated genes showed that anti-apoptosis effects of NK-4 in the retina of RCS rats may be related to the pathways of metal ion homeostasis, negative regulation of neuron death, response to toxic substance, and pigment metabolic process. We found a potential mechanism of NK-4, providing a new viewpoint for the development of more therapeutic uses of NK-4 in the future.

scholarly journals AAV Mediated GDNF Secretion From Retinal Glia Slows Down Retinal Degeneration in a Rat Model of Retinitis Pigmentosa

2011 ◽  
Vol 19 (9) ◽  
pp. 1602-1608 ◽  
Author(s):  
Deniz Dalkara ◽  
Kathleen D Kolstad ◽  
Karen I Guerin ◽  
Natalie V Hoffmann ◽  
Meike Visel ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Retinal Degeneration ◽  
Rat Model

Spatiotemporal pattern of rod degeneration in the S334ter-line-3 rat model of retinitis pigmentosa

2012 ◽  
Vol 351 (1) ◽  
pp. 29-40 ◽  
Author(s):  
Colleen L. Zhu ◽  
Yerina Ji ◽  
Eun-Jin Lee ◽  
Norberto M. Grzywacz
Keyword(s):  
Retinitis Pigmentosa ◽  
Rat Model ◽  
Spatiotemporal Pattern

scholarly journals Retinal Vascular Degeneration in the Transgenic P23H Rat Model of Retinitis Pigmentosa

2018 ◽  
Vol 12 ◽  
Author(s):  
Laura Fernández-Sánchez ◽  
Gema Esquiva ◽  
Isabel Pinilla ◽  
Pedro Lax ◽  
Nicolás Cuenca
Keyword(s):  
Retinitis Pigmentosa ◽  
Rat Model

scholarly journals AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa

2003 ◽  
Vol 8 (2) ◽  
pp. 188-195 ◽  
Author(s):  
Alexander J Smith ◽  
Frank C Schlichtenbrede ◽  
Marion Tschernutter ◽  
James W Bainbridge ◽  
Adrian J Thrasher ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Retinitis Pigmentosa ◽  
Rat Model ◽  
Rcs Rat
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