scholarly journals Prediction Accuracy of a Novel Dynamic Structure-Function Model for Glaucoma Progression

2014 ◽  
Vol 55 (12) ◽  
pp. 8086-8094 ◽  
Author(s):  
R. Hu ◽  
I. Marin-Franch ◽  
L. Racette
Keyword(s):  
Structure Function ◽  
Prediction Accuracy ◽  
Dynamic Structure ◽  
Function Model ◽  
Glaucoma Progression

Dynamic Structure Function of 3He-4He Mixtures in the Deep Inelastic Regime

1995 ◽  
pp. 101-107
Author(s):  
A. Polls ◽  
F. Mazzanti ◽  
J. Boronat ◽  
F. Dalfovo ◽  
A. Fabrocini
Keyword(s):  
Structure Function ◽  
Dynamic Structure

Phycobilisomes; a Structure-Function Model

2018 ◽  
pp. 9-24
Author(s):  
Robert MacColl ◽  
Deborah Guard-Friar
Keyword(s):  
Structure Function ◽  
Function Model

scholarly journals Secondary Structural Model of Human MALAT1 Reveals Multiple Structure–Function Relationships

2019 ◽  
Vol 20 (22) ◽  
pp. 5610 ◽  
Author(s):  
Phillip J. McCown ◽  
Matthew C. Wang ◽  
Luc Jaeger ◽  
Jessica A. Brown
Keyword(s):  
Structure Function ◽  
Noncoding Rna ◽  
Structural Model ◽  
Dynamic Structure ◽  
Nucleotide Polymorphisms ◽  
Rna Structures ◽  
Rna Modifications ◽  
Functional Roles ◽  
Conserved Core

Human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is an abundant nuclear-localized long noncoding RNA (lncRNA) that has significant roles in cancer. While the interacting partners and evolutionary sequence conservation of MALAT1 have been examined, much of the structure of MALAT1 is unknown. Here, we propose a hypothetical secondary structural model for 8425 nucleotides of human MALAT1 using three experimental datasets that probed RNA structures in vitro and in various human cell lines. Our model indicates that approximately half of human MALAT1 is structured, forming 194 helices, 13 pseudoknots, five structured tetraloops, nine structured internal loops, and 13 intramolecular long-range interactions that give rise to several multiway junctions. Evolutionary conservation and covariation analyses support 153 of 194 helices in 51 mammalian MALAT1 homologs and 42 of 194 helices in 53 vertebrate MALAT1 homologs, thereby identifying an evolutionarily conserved core that likely has important functional roles in mammals and vertebrates. Data mining revealed that RNA modifications, somatic cancer-associated mutations, and single-nucleotide polymorphisms may induce structural rearrangements that sequester or expose binding sites for several cancer-associated microRNAs. Our findings reveal new mechanistic leads into the roles of MALAT1 by identifying several intriguing structure–function relationships in which the dynamic structure of MALAT1 underlies its biological functions.

scholarly journals Dynamic structure function in3He-4He mixtures

1994 ◽  
Vol 194-196 ◽  
pp. 859-860
Author(s):  
J. Boronat ◽  
F. Dalfovo ◽  
F. Mazzanti ◽  
A. Polls
Keyword(s):  
Structure Function ◽  
Dynamic Structure
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