scholarly journals Caveolin-1 Increases Proinflammatory Chemoattractants and Blood–Retinal Barrier Breakdown but Decreases Leukocyte Recruitment in Inflammation

2014 ◽  
Vol 55 (10) ◽  
pp. 6224 ◽  
Author(s):  
Xiaoman Li ◽  
Xiaowu Gu ◽  
Timothy M. Boyce ◽  
Min Zheng ◽  
Alaina M. Reagan ◽  
...  
Keyword(s):  
Leukocyte Recruitment ◽  
Blood Retinal Barrier ◽  
Caveolin 1 ◽  
Barrier Breakdown

scholarly journals Loss of Caveolin-1 Causes Blood–Retinal Barrier Breakdown, Venous Enlargement, and Mural Cell Alteration

2014 ◽  
Vol 184 (2) ◽  
pp. 541-555 ◽  
Author(s):  
Xiaowu Gu ◽  
Steven J. Fliesler ◽  
You-Yang Zhao ◽  
William B. Stallcup ◽  
Alex W. Cohen ◽  
...  
Keyword(s):  
Blood Retinal Barrier ◽  
Mural Cell ◽  
Caveolin 1 ◽  
Barrier Breakdown

Experimental models of growth factor-mediated angiogenesis and blood–retinal barrier breakdown

2000 ◽  
Vol 35 (5) ◽  
pp. 233-239 ◽  
Author(s):  
Stanley A. Vinores ◽  
M.S. Seo ◽  
N. Okamoto ◽  
J.D. Ash ◽  
E.F. Wawrousek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Experimental Models ◽  
Blood Retinal Barrier ◽  
Barrier Breakdown

scholarly journals TNFSF15 Inhibits Blood Retinal Barrier Breakdown Induced by Diabetes

2016 ◽  
Vol 17 (5) ◽  
pp. 615 ◽  
Author(s):  
Feng Jiang ◽  
Qingzhong Chen ◽  
Liming Huang ◽  
Ying Wang ◽  
Zhuhong Zhang ◽  
...  
Keyword(s):  
Blood Retinal Barrier ◽  
Barrier Breakdown

Characterization of Azurocidin as a Permeability Factor in the Retina: Involvement in VEGF-Induced and Early Diabetic Blood-Retinal Barrier Breakdown

2008 ◽  
Vol 49 (2) ◽  
pp. 726 ◽  
Author(s):  
Dimitra Skondra ◽  
Kousuke Noda ◽  
Lama Almulki ◽  
Faryan Tayyari ◽  
Sonja Frimmel ◽  
...  
Keyword(s):  
Blood Retinal Barrier ◽  
Permeability Factor ◽  
Barrier Breakdown

scholarly journals Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation

2020 ◽  
Vol 397 (2) ◽  
pp. 112347
Author(s):  
Anton Lennikov ◽  
Anthony Mukwaya ◽  
Lijuan Fan ◽  
Madhu Sudhana Saddala ◽  
Sandro De Falco ◽  
...  
Keyword(s):  
Blood Retinal Barrier ◽  
Synergistic Interactions ◽  
Barrier Breakdown

scholarly journals Aflibercept ameliorates retinal pericyte loss and restores perfusion in streptozotocin-induced diabetic mice

2020 ◽  
Vol 8 (1) ◽  
pp. e001278
Author(s):  
Eoi Jong Seo ◽  
Jeong A Choi ◽  
Jae-Young Koh ◽  
Young Hee Yoon
Keyword(s):  
Growth Factor ◽  
Murine Model ◽  
Early Stage ◽  
Blood Glucose Control ◽  
Growth Factor Receptor ◽  
Fluorescein Isothiocyanate ◽  
Leukocyte Recruitment ◽  
Blood Retinal Barrier ◽  
Anti Vegf ◽  
Pericyte Loss

IntroductionAnti-vascular endothelial growth factor (VEGF) agents are used worldwide for advanced-stage diabetic retinopathy (DR). In contrast, apart from blood glucose control, there are no specific treatments that can limit the progression of early-stage DR that starts with pericyte loss and the destruction of the blood–retinal barrier. Here, we examined the efficacy of aflibercept, a potent anti-VEGF agent, against early-DR pathologies in a murine model of streptozotocin (STZ)-induced DR.Research design and methodsSTZ was intraperitoneally administered in 8-week-old C57BL/6N male mice. After 4 weeks, the mice were divided into aflibercept-treated and saline-treated groups. Eight weeks after the STZ injection, vascular permeability/leakage was measured with fluorescein angiography in live mice. At 4, 6, and 8 weeks after the STZ injection, the eyes were enucleated, flat-mounted, and stained for platelet-derived growth factor receptor-β to assess pericyte abundance, CD45 to assess leukocyte recruitment, and fluorescein isothiocyanate dextran to assess perfusion. VEGF levels were quantified in each group. The effects of aflibercept on pericyte number, perfusion status, and leukocyte recruitment/accumulation on mice with diabetes retina were evaluated.ResultsOur murine model successfully replicated the salient pathologies of DR such as pericytes loss, hyperpermeability, and perfusion blockage. Interestingly, numerous leukocytes and leukocyte clumps were found in diabetic retinal capillaries, especially in the non-perfused border area of the retina, suggesting a possible mechanism for non-perfusion and related pericyte damage. Treatment with aflibercept in mice with diabetes inhibited the upregulation of VEGF and the associated adhesion molecules while reducing the defects in perfusion. Aflibercept also attenuated pericyte loss in the diabetic retina.ConclusionVEGF inhibition through aflibercept treatment decreased leukocyte recruitment and aggregation, perfusion blockage, retinal hypoperfusion, and hyperpermeability in mice with diabetes and ultimately attenuated pericyte loss. Our findings suggest that anti-VEGF strategies may prove useful as possible therapies for limiting the progression of early-stage DR.

The effect of apolipoprotein j/clusterin on blood–retinal barrier breakdown of streptozotocin-induced diabetic rat

2006 ◽  
Vol 45 (3) ◽  
pp. e155
Author(s):  
Jeong Hun Kim ◽  
Jin Hyoung Kim ◽  
Yong Hae Son ◽  
Kyu-Won Kim ◽  
Young Suk Yu
Keyword(s):  
Diabetic Rat ◽  
Blood Retinal Barrier ◽  
Apolipoprotein J ◽  
Barrier Breakdown
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