scholarly journals A Hypoxia-Responsive Glial Cell-Specific Gene Therapy Vector for Targeting Retinal Neovascularization

2014 ◽  
Vol 55 (12) ◽  
pp. 8044-8053 ◽  
Author(s):  
M. R. Biswal ◽  
H. M. Prentice ◽  
C. K. Dorey ◽  
J. C. Blanks
Keyword(s):  
Gene Therapy ◽  
Glial Cell ◽  
Retinal Neovascularization ◽  
Specific Gene ◽  
Gene Therapy Vector

scholarly journals AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy

2021 ◽  
Vol 13 ◽  
Author(s):  
Simon J. O’Carroll ◽  
William H. Cook ◽  
Deborah Young
Keyword(s):  
Gene Therapy ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Glial Cell ◽  
Cell Types ◽  
Nerve Degeneration ◽  
Specific Gene ◽  
Cell Type ◽  
Adeno Associated Virus ◽  
Brain And Spinal Cord

Different glial cell types are found throughout the central (CNS) and peripheral nervous system (PNS), where they have important functions. These cell types are also involved in nervous system pathology, playing roles in neurodegenerative disease and following trauma in the brain and spinal cord (astrocytes, microglia, oligodendrocytes), nerve degeneration and development of pain in peripheral nerves (Schwann cells, satellite cells), retinal diseases (Müller glia) and gut dysbiosis (enteric glia). These cell type have all been proposed as potential targets for treating these conditions. One approach to target these cell types is the use of gene therapy to modify gene expression. Adeno-associated virus (AAV) vectors have been shown to be safe and effective in targeting cells in the nervous system and have been used in a number of clinical trials. To date, a number of studies have tested the use of different AAV serotypes and cell-specific promoters to increase glial cell tropism and expression. However, true glial-cell specific targeting for a particular glial cell type remains elusive. This review provides an overview of research into developing glial specific gene therapy and discusses some of the issues that still need to be addressed to make glial cell gene therapy a clinical reality.

scholarly journals Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy

2002 ◽  
Vol 9 (4) ◽  
pp. 365-371 ◽  
Author(s):  
Anders Høgset ◽  
Birgit Øvstebø Engesæter ◽  
Lina Prasmickaite ◽  
Kristian Berg ◽  
Øystein Fodstad ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
Gene Delivery ◽  
Cancer Gene Therapy ◽  
Specific Gene ◽  
Cancer Gene ◽  
Delivery Technology

scholarly journals Hypoxia-Inducible Regulation of a Prodrug-Activating Enzyme for Tumor-Specific Gene Therapy

Neoplasia ◽  
2002 ◽  
Vol 4 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Toru Shibata ◽  
Amato J. Giaccia ◽  
J. Martin Brown
Keyword(s):  
Gene Therapy ◽  
Specific Gene

Increased Survival and Function of SOD1 Mice After Glial Cell-Derived Neurotrophic Factor Gene Therapy

2002 ◽  
Vol 13 (9) ◽  
pp. 1047-1059 ◽  
Author(s):  
Gyula Acsadi ◽  
Roumen A. Anguelov ◽  
Huibin Yang ◽  
Gabor Toth ◽  
Ronald Thomas ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Factor Gene ◽  
And Function
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