Evaluating In Vivo Delivery of Riboflavin With Coulomb-Controlled Iontophoresis for Corneal Collagen Cross-Linking: A Pilot Study

2014 ◽  
Vol 55 (4) ◽  
pp. 2731 ◽  
Author(s):  
Alejandro Arboleda ◽  
Laura Kowalczuk ◽  
Michèle Savoldelli ◽  
Christophe Klein ◽  
Sophia Ladraa ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cross Linking ◽  
In Vivo Delivery ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Supersonic Shear Wave Elastography for the In Vivo Evaluation of Transepithelial Corneal Collagen Cross-Linking

2014 ◽  
Vol 55 (3) ◽  
pp. 1976 ◽  
Author(s):  
David Touboul ◽  
Jean-Luc Gennisson ◽  
Thu-Mai Nguyen ◽  
Antoine Robinet ◽  
Cynthia J. Roberts ◽  
...  
Keyword(s):  
Shear Wave ◽  
Shear Wave Elastography ◽  
Cross Linking ◽  
In Vivo Evaluation ◽  
Collagen Cross Linking ◽  
Corneal Collagen

A case of in vivo iontophoresis-assisted corneal collagen cross-linking for keratoconus: An immunohistochemical study

2017 ◽  
Vol 119 (3) ◽  
pp. 343-347 ◽  
Author(s):  
Mirko Manetti ◽  
Eleonora Favuzza ◽  
Eleonora Sgambati ◽  
Rita Mencucci ◽  
Mirca Marini
Keyword(s):  
Immunohistochemical Study ◽  
Cross Linking ◽  
Collagen Cross Linking ◽  
Corneal Collagen

scholarly journals Efficacy and Safety of LASIK Combined with Accelerated Corneal Collagen Cross-Linking for Myopia: Six-Month Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Ying Wu ◽  
Lei Tian ◽  
Li-qiang Wang ◽  
Yi-fei Huang
Keyword(s):  
Clinical Trial ◽  
Cross Linking ◽  
Controlled Clinical Trial ◽  
Morphologic Change ◽  
Efficacy And Safety ◽  
Collagen Cross Linking ◽  
Keratocyte Density ◽  
Corneal Collagen

This was a prospective controlled clinical trial. 48 myopia patients (96 eyes) were included in this study. After LASIK, accelerated corneal collagen cross-linking (ACXL) was used for myopia treatment. During 6-month follow-up, the results of LASIK-ACXL treatment were studied and compared to the LASIK-only procedure. The results showed that no statistically significant differences in UDVA, CDVA, MRSE,Kmean, pachymetry, or ECD were found between the two groups at the visit after 6 months of follow-up (allP>0.05). At 6 months postoperatively, 2 eyes lost one or more lines of visual acuity in the LASIK-ACXL group, whereas all LASIK-only treated eyes had a stable CDVA.In vivoconfocal microscopy showed a decrease of keratocyte density and appearance of honeycomb-like structures in the anterior residual stroma bed; the changes were similar but more pronounced following LASIK-only. None of the cases in both groups developed signs of significant keratitis, regression, or ectasia during the 6-month follow-up. LASIK-ACXL can effectively correct refractive error in patients with myopia, with no significant complications during 6-month follow-up, indicating stability and morphologic change similar to those with LASIK-only treatment.

scholarly journals Corneal Collagen Cross-Linking Pretreatment Mitigates Injury-Induced Inflammation, Hemangiogenesis and Lymphangiogenesis In Vivo

2021 ◽  
Vol 10 (5) ◽  
pp. 11
Author(s):  
Yirui Zhu ◽  
Peter S. Reinach ◽  
Chaoxiang Ge ◽  
Yun Li ◽  
Biao Wu ◽  
...  
Keyword(s):  
Cross Linking ◽  
Collagen Cross Linking ◽  
Corneal Collagen

scholarly journals Mueller Matrix-Based Approach for the Ex Vivo Detection of Riboflavin-Treated Transparent Biotissue

2021 ◽  
Vol 11 (23) ◽  
pp. 11515
Author(s):  
Lennart Jütte ◽  
Gaurav Sharma ◽  
Dierk Fricke ◽  
Maximilian Franke ◽  
Merve Wollweber ◽  
...  
Keyword(s):  
Mechanical Stability ◽  
Ex Vivo ◽  
Measurement Data ◽  
Mueller Matrix ◽  
Cross Linking ◽  
Sample Number ◽  
Non Invasive ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Corneal collagen cross-linking is an established procedure for the treatment of certain eye diseases which is applied to enhance the mechanical stability of such biotissue without deteriorating its functionality. However, being transparent, the optical analysis of the outcome of such treatments is cumbersome and relies on relatively expensive experimental equipment. We aim to apply the Mueller matrix polarimetry for the detection of photo-induced collagen cross-linking in transparent biotissue after treatment with riboflavin and UV irradiation. A simple Mueller matrix polarimetry setup could provide a fast and non-invasive analysis of transparent media to sensitively detect small photo-induced cross-linking effects in biotissue. We demonstrated the current capabilities of the approach on non-planar porcine cornea samples ex vivo. We reported the distinction between untreated and riboflavin-treated samples. The differences observed were correlated with the variation of certain Mueller matrix elements and parameters derived from the decomposition. The measurement data show variation in the cross-linked and non-cross-linked samples, although the effect of the UV treatment on the riboflavin-treated samples was not at the same level of significance yet and needs further investigation. The Mueller matrix measurement represents a promising approach for the detection of the effects of corneal collagen cross-linking. Further studies with a larger sample number are required to validate this approach. In the future, this could enable the reliable and non-invasive detection of photo-induced effects in biotissue and open the possibility for in vivo application, e.g., in eye disease treatment or the detection of scar collagen development.

scholarly journals Corneal collagen cross-linking (CXL) for the treatment of melting keratitis in cats and dogs: a pilot study

2013 ◽  
Vol 17 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Bernhard M. Spiess ◽  
Simon A. Pot ◽  
Marion Florin ◽  
Farhad Hafezi
Keyword(s):  
Pilot Study ◽  
Cross Linking ◽  
Collagen Cross Linking ◽  
Corneal Collagen
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