Association of Aqueous Humor Cytokines With the Development of Retinal Ischemia and Recurrent Macular Edema in Retinal Vein Occlusion

2014 ◽  
Vol 55 (4) ◽  
pp. 2290 ◽  
Author(s):  
Sang Hoon Jung ◽  
Kyung-A. Kim ◽  
Sea Woon Sohn ◽  
Sung Jae Yang
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Aqueous Humor ◽  
Retinal Ischemia ◽  
Vein Occlusion

scholarly journals Metabolite Changes in the Aqueous Humor of Patients With Retinal Vein Occlusion Macular Edema: A Metabolomics Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiaojing Xiong ◽  
Xu Chen ◽  
Huafeng Ma ◽  
Zheng Zheng ◽  
Yazhu Yang ◽  
...  
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Aqueous Humor ◽  
High Performance ◽  
Coenzyme A ◽  
Enrichment Analysis ◽  
Pathway Enrichment Analysis ◽  
Roc Curve Analysis ◽  
Vein Occlusion ◽  
Coenzyme A Biosynthesis

Macular edema (ME) is the main cause of visual impairment in patients with retinal vein occlusion (RVO). The degree of ME affects the prognosis of RVO patients, while it lacks objective laboratory biomarkers. We aimed to compare aqueous humor samples from 28 patients with retinal vein occlusion macular edema (RVO-ME) to 27 age- and sex-matched controls by ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry, so as to identify the key biomarkers and to increase the understanding of the mechanism of RVO-ME at the molecular level. Through univariate and multivariate statistical analyses, we identified 60 metabolites between RVO-ME patients and controls and 40 differential metabolites in mild RVO-ME [300 μm ≤ central retinal thickness (CRT) < 400 μm] patients compared with severe RVO-ME (CRT ≥ 400 μm). Pathway enrichment analysis showed that valine, leucine, and isoleucine biosynthesis; ascorbate and aldarate metabolism; and pantothenate and coenzyme A biosynthesis were significantly altered in RVO-ME in comparison with controls. Compared with mild RVO-ME, degradation and biosynthesis of valine, leucine, and isoleucine; histidine metabolism; beta-alanine metabolism; and pantothenate and coenzyme A biosynthesis were significantly changed in severe RVO-ME. Furthermore, the receiver operating characteristic (ROC) curve analysis revealed that adenosine, threonic acid, pyruvic acid, and pyro-L-glutaminyl-l-glutamine could differentiate RVO-ME from controls with an area under the curve (AUC) of >0.813. Urocanic acid, diethanolamine, 8-butanoylneosolaniol, niacinamide, paraldehyde, phytosphingosine, 4-aminobutyraldehyde, dihydrolipoate, and 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide had an AUC of >0.848 for distinguishing mild RVO-ME from severe RVO-ME. Our study expanded the understanding of metabolomic changes in RVO-ME, which could help us to have a good understanding of the pathogenesis of RVO-ME.

scholarly journals Epidemiology, Prevalence and Incidence in Branch Retinal Vein Occlusion and Macular Edema

2019 ◽  
pp. 65-67
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Older Patients ◽  
Visual Loss ◽  
Retinal Ischemia ◽  
Vein Occlusion ◽  
Retinal Vascular Disease ◽  
Central Retinal Vein

Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy. RVO exists in two subtypes: CRVO (central retinal vein occlusion), which is less common and represents occlusion of the central retinal vein, and BRVO (branch retinal vein occlusion), which is 4-6 times more common and represents occlusion of some branches of central retinal vein. RVO is a relatively common and frequently devastating cause of visual loss mainly in older patients. Its prevalence varies according to studies in overall populations from 5.2 to 16 per 1000. Visual acuity is primarily decreased due to macular edema and retinal ischemia.

AQUEOUS HUMOR CYTOKINES AND THERAPEUTIC CUSTOMIZATION IN NONRESPONDING MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Aditya Modi ◽  
Karen Sharma ◽  
Neha Peraka Sudhakar ◽  
Naresh Kumar Yadav
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Aqueous Humor ◽  
Vein Occlusion

Epidemiology, Prevalence, and Incidence in Central Retinal Vein Occlusion and Macular Edema

2019 ◽  
pp. 2-4
Keyword(s):  
General Population ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Visual Loss ◽  
Retinal Ischemia ◽  
Common Cause ◽  
Vein Occlusion ◽  
Common Causes ◽  
Central Retinal Vein

Retinal vein occlusion (RVO) is one of the most common causes of acquired retinal vascular anomalies in adults and is a common cause of visual loss. There is little data on the prevalence of RVO in the general population, although it is at least as early as 1855 and there are more than 3000 publications. The number of studies on the incidence of RVO is relatively small. Reduced vision in patients affected by RVO can result from retinal ischemia and/or accumulation of fluid in the center of the retina (macular edema). In this review, studies on epidemiology, prevalence, and incidence in central retinal vein occlusion and macular edema were summarized and evaluated.

Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation

2018 ◽  
Vol 61 (4) ◽  
pp. 218-225 ◽  
Author(s):  
Taneto Tomiyasu ◽  
Yoshio Hirano ◽  
Norihiro Suzuki ◽  
Yuya Esaki ◽  
Yusuke Yasuda ◽  
...  
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Retinal Ischemia ◽  
Vein Occlusion ◽  
Functional Analyses
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