The Effects of 2% Rebamipide Ophthalmic Solution on the Tear Functions and Ocular Surface of the Superoxide Dismutase-1 (Sod1) Knockout Mice

2013 ◽  
Vol 54 (12) ◽  
pp. 7793 ◽  
Author(s):  
Takeshi Ohguchi ◽  
Takashi Kojima ◽  
Osama M. Ibrahim ◽  
Taeko Nagata ◽  
Takahiko Shimizu ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Knockout Mice ◽  
Ocular Surface ◽  
Ophthalmic Solution ◽  
Superoxide Dismutase 1

Ascorbic acid and CoQ10 ameliorate the reproductive ability of superoxide dismutase 1-deficient female mice†

2019 ◽  
Author(s):  
Naoki Ishii ◽  
Takujiro Homma ◽  
Jaeyong Lee ◽  
Hikaru Mitsuhashi ◽  
Ken-ichi Yamada ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Superoxide Dismutase ◽  
Coenzyme Q10 ◽  
Knockout Mice ◽  
Knockout Mouse ◽  
Superoxide Dismutase 1 ◽  
Wild Type ◽  
Positive Effects ◽  
Reproductive Ability ◽  
Ascorbic Acid Supplementation

Abstract Superoxide dismutase 1 suppresses oxidative stress within cells by decreasing the levels of superoxide anions. A dysfunction of the ovary and/or an aberrant production of sex hormones are suspected causes for infertility in superoxide dismutase 1-knockout mice. We report on attempts to rescue the infertility in female knockout mice by providing two antioxidants, ascorbic acid and/or coenzyme Q10, as supplements in the drinking water of the knockout mice after weaning and on an investigation of their reproductive ability. On the first parturition, 80% of the untreated knockout mice produced smaller litter sizes compared with wild-type mice (average 2.8 vs 7.3 pups/mouse), and supplementing with these antioxidants failed to improve these litter sizes. However, in the second parturition of the knockout mice, the parturition rate was increased from 18% to 44–75% as the result of the administration of antioxidants. While plasma levels of progesterone at 7.5 days of pregnancy were essentially the same between the wild-type and knockout mice and were not changed by the supplementation of these antioxidants, sizes of corpus luteum cells, which were smaller in the knockout mouse ovaries after the first parturition, were significantly ameliorated in the knockout mouse with the administration of the antioxidants. Moreover, the impaired vasculogenesis in uterus/placenta was also improved by ascorbic acid supplementation. We thus conclude that ascorbic acid and/or coenzyme Q10 are involved in maintaining ovarian and uterus/placenta homeostasis against insults that are augmented during pregnancy and that their use might have positive effects in terms of improving female fertility.

scholarly journals The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 (Sod1) Knockout Mice

2018 ◽  
Vol 59 (3) ◽  
pp. 1675 ◽  
Author(s):  
Takashi Kojima ◽  
Cem Simsek ◽  
Ayako Igarashi ◽  
Kazue Aoki ◽  
Kazunari Higa ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Knockout Mice ◽  
Eye Drops ◽  
Superoxide Dismutase 1

scholarly journals Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis

FEBS Open Bio ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. 522-532 ◽  
Author(s):  
Yoshitaka Kondo ◽  
Hirofumi Masutomi ◽  
Yoshihiro Noda ◽  
Yusuke Ozawa ◽  
Keita Takahashi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Hepatic Steatosis ◽  
Knockout Mice ◽  
Superoxide Dismutase 1 ◽  
Marker Protein ◽  
Double Knockout

Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 (Sod1)–Knockout Mice

2015 ◽  
Vol 56 (13) ◽  
pp. 8382 ◽  
Author(s):  
Takashi Kojima ◽  
Murat Dogru ◽  
Osama M. A. Ibrahim ◽  
Tais Hitomi Wakamatsu ◽  
Masataka Ito ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Knockout Mice ◽  
Superoxide Dismutase 1

scholarly journals Ovarian Function in Superoxide Dismutase 1 and 2 Knockout Mice

Endocrinology ◽  
1998 ◽  
Vol 139 (9) ◽  
pp. 4008-4011 ◽  
Author(s):  
Martin M. Matzuk ◽  
Lianna Dionne ◽  
Qiuxia Guo ◽  
T. Rajendra Kumar ◽  
Russell M. Lebovitz
Keyword(s):  
Superoxide Dismutase ◽  
Knockout Mice ◽  
Ovarian Function ◽  
Superoxide Dismutase 1

scholarly journals Oxidative Stress Induced Age Dependent Meibomian Gland Dysfunction in Cu, Zn-Superoxide Dismutase-1 (Sod1) Knockout Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e99328 ◽  
Author(s):  
Osama M. A. Ibrahim ◽  
Murat Dogru ◽  
Yukihiro Matsumoto ◽  
Ayako Igarashi ◽  
Takashi Kojima ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Knockout Mice ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Superoxide Dismutase 1 ◽  
Age Dependent
Sign in / Sign up

Export Citation Format

Share Document