scholarly journals Intercellular Adhesion Molecule 1 Mediates Migration of Th1 and Th17 Cells Across Human Retinal Vascular Endothelium

2013 ◽  
Vol 54 (10) ◽  
pp. 6917 ◽  
Author(s):  
Arpita S. Bharadwaj ◽  
Lauren P. Schewitz-Bowers ◽  
Lai Wei ◽  
Richard W. J. Lee ◽  
Justine R. Smith
Keyword(s):  
Adhesion Molecule ◽  
Vascular Endothelium ◽  
Th17 Cells ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1

scholarly journals Mild Hypothermia Attenuates Intercellular Adhesion Molecule-1 Induction via Activation of Extracellular Signal-Regulated Kinase-1/2 in a Focal Cerebral Ischemia Model

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Jung Sook Choi ◽  
Jaechan Park ◽  
Kyoungho Suk ◽  
Cheil Moon ◽  
Yong-Ki Park ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Adhesion Molecule ◽  
Vascular Endothelium ◽  
Focal Cerebral Ischemia ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Hypothermic Condition

Intercellular adhesion molecule-1 (ICAM-1) in cerebral vascular endothelium induced by ischemic insult triggers leukocyte infiltration and inflammatory reaction. We investigated the mechanism of hypothermic suppression of ICAM-1 in a model of focal cerebral ischemia. Rats underwent 2 hours of middle cerebral artery occlusion and were kept at 37°C or 33°C during occlusion and rewarmed to normal temperature immediately after reperfusion. Under hypothermic condition, robust activation of extracellular signal-regulated kinase-1/2 (ERK1/2) was observed in vascular endothelium of ischemic brain. Hypothermic suppression of ICAM-1 was reversed by ERK1/2 inhibition. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) in ischemic vessel was attenuated by hypothermia. STAT3 inhibitor suppressed ICAM-1 production induced by stroke. ERK1/2 inhibition enhanced phosphorylation and DNA binding activity of STAT3 in hypothermic condition. In this study, we demonstrated that hypothermic suppression of ICAM-1 induction is mediated by enhanced ERK1/2 activation and subsequent attenuation of STAT3 action.

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