Lack of Association Between Primary Angle-Closure Glaucoma Susceptibility Loci and the Ocular Biometric Parameters Anterior Chamber Depth and Axial Length

2013 ◽  
Vol 54 (8) ◽  
pp. 5824 ◽  
Author(s):  
Monisha E. Nongpiur ◽  
Xin Wei ◽  
Liang Xu ◽  
Shamira A. Perera ◽  
Ren-Yi Wu ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Axial Length ◽  
Anterior Chamber Depth ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Susceptibility Loci ◽  
Biometric Parameters ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

scholarly journals A Rare Case of Chronic Primary Angle-Closure Glaucoma in a Young Woman with Coexisting Pathologic Myopia

2021 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Ni Putu Ayu Reza Dhiyantari ◽  
Nurwasis Nurwasis ◽  
Evelyn Komaratih ◽  
Yulia Primitasari
Keyword(s):  
Anterior Chamber ◽  
Axial Length ◽  
Rare Case ◽  
Retinal Pigment ◽  
Anterior Chamber Depth ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Pathologic Myopia ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Introduction: Primary Angle-Closure Glaucoma (PACG) is usually present in adults older than forty and is more common in hyperopic eyes. Angle-closure is usually related to structural or developmental ocular abnormalities in young individuals. Case presentation: We presented a rare case of PACG in a 32 years old woman with pathologic myopia of -23.0 RLE. The chief complaint was blurring of the right eye three months before the visit. Right eye Intraocular Pressure (IOP) was 30mmHg-38mmHg despite treatment with three intra-ocular pressure-lowering agents. Axial length was 32.36 mm and 31.19 mm RLE. Anterior chamber depth was 2.36 mm and 2.60 mm RLE. Lens thickness was 5.07 mm and 5.40 mm RLE. Signs of GON and pathologic myopia were found in both eyes. GON was present asymmetrically (0.9 and 0.6 RLE), with the myopic crescent as well as baring and peripapillary atrophy. The optic disc was slightly tilted with the myopic crescent. There was also a marked sign of retinal pigment epithelium thinning and attenuation along with myopic chorioretinal atrophy. Conclusions: PACG in a young myopic individual is challenging to diagnose because myopia and glaucoma share similar optic nerve head pathology. Comprehensive examinations including gonioscopy, biometry, and OCT may confirm the diagnosis. In the presented case, angle-closure was caused by thick lenses and a shallow anterior chamber, along with excessively long axial length. Primary angle-closure at a young individual with myopic eyes is highly uncommon. Nonetheless, clinicians should always consider glaucoma even in the presence of high axial length and myopic fundus.

scholarly journals ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma

PLoS Genetics ◽  
2014 ◽  
Vol 10 (3) ◽  
pp. e1004089 ◽  
Author(s):  
Monisha E. Nongpiur ◽  
Chiea Chuen Khor ◽  
Hongyan Jia ◽  
Belinda K. Cornes ◽  
Li-Jia Chen ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Anterior Chamber Depth ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

scholarly journals CORRELATION BETWEEN LOCUS POLYMORPHISM OF COL11A1 GENE AND OCULAR BIOMETRY IN ACUTE AND CHRONIC PRIMARY ANGLE CLOSURE GLAUCOMA

2021 ◽  
pp. 41-45
Author(s):  
FITRATUL ILAHI ◽  
ANDIKA PRAHASTA ◽  
RIKA SUSANTI ◽  
JAMSARI JAMSARI
Keyword(s):  
Dna Isolation ◽  
Anterior Chamber Depth ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Blood Samples ◽  
Biometric Parameters ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Ocular Biometry ◽  
Significant Difference

Objective: The objective of this study is to analyze the correlation between locus polymorphisms of genetics variants of rs3753841 (COL11A1) and ocular biometry, including anterior chamber depth (ACD), axial length (AL), and lens thickness (LT) in acute and chronic primary angle-closure glaucoma (PACG) patients. Methods: A total of 50 patients consisting of 25 acute PACG and 25 chronic PACG patients were included in this study. Ocular biometric parameters including anterior ACD, AL, and LT measurement were performed in all subjects using A-scan biometry. DNA isolation from blood samples was performed using PCR sequencing for genotyping locus polymorphisms of rs3753841 (COL11A1). Results: Mean ACD was shallower (2.40±0.40 mm), mean AL was shorter (21.86±1.31 mm), and mean LT was thicker (5.01±0.49 mm) in acute PACG compared to chronic PACG group, yet with no significant difference (p>0.05). We found a statistically significant difference of rs3753841 (COL11A1) polymorphism, with heterozygous mutant was mostly found in chronic PACG and homozygous mutant was mostly found in acute PACG patients (p<0.05). Significant correlations were also found between the locus polymorphism and ocular biometry (ACD and AL) in chronic PACG (p<0.05). Conclusion: We confirmed the polymorphisms of rs3753841 (COL11A1) in both groups and its significant correlation with ocular biometry (ACD and AL) in chronic PACG.

Elucidation of presence of increased risk formation of primary angle-closure glaucoma among patients with hyperopia in department of refractive surgery

2021 ◽  
pp. 162-164
Author(s):  
N.V. Samokhvalov ◽  
◽  
E.L. Sorokin ◽  
A.N. Marchenko ◽  
Y.E. Pashentsev ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Refractive Surgery ◽  
Young Patients ◽  
Anterior Chamber Depth ◽  
Acute Attack ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Increased Risk

Important physiological feature of the anatomically «short» eye is the disproportionately large volume of the lens relative to the volume of the eye. A gradual and continuous increase in the volume of the lens contributes to the anterior displacement of the irido-lenticular diaphragm, causing the functional block of the anterior chamber angle. This leads to persistent disorders of the hydrodynamics of the eye, up to the development of an acute attack of angle-closure glaucoma. Purpose. To study incidence of increased risk formation of primary angle-closure glaucoma (PACG) and its acute attack in young patients with moderate and high hyperopia (Hm). Material and methods. Clinical material was presented by 58 patients (116 eyes) with indicators of axial length of the eyes less than 23 mm. The main group consisted of 33 patients (66 eyes) with moderate and high Hm. The comparison group was represented by 25 patients (50 eyes) with PACG. Results. The study made it possible to identify group of increased risk of the formation of PACG, which included 19 people (58%), from selected general population of young patients with moderate and high Hm. Conclusion. Comparative analysis of morphometric parameters of structures of the anterior segment of the anatomically «short» eyes in young patients with moderate and high Hm, on the one hand, and in patients with PACG, on the other, revealed statistically significant differences between them in the anterior chamber depth in the central zone, the thickness of the lens, the anterior chamber volume, the peripheral anterior chamber depth, of the anterior chamber angle. Key words: primary angle-closure glaucoma, acute attack of angle-closure glaucoma, hyperopia, refractive surgery.

scholarly journals Anterior Segment Morphology in Primary Angle Closure Glaucoma using Ultrasound Biomicroscopy

2017 ◽  
Vol 11 (3) ◽  
pp. 86-91 ◽  
Keyword(s):  
Anterior Chamber ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Normal Subjects ◽  
Ultrasound Biomicroscopy ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Ciliary Process ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

ABSTRACT Aim To evaluate the configuration of the anterior chamber angle quantitatively and study the morphological changes in the eye with ultrasound biomicroscopy (UBM) in primary angle closure glaucoma (PACG) patients after laser peripheral iridotomy (LPI). Materials and methods A total of 185 eyes of 185 PACG patients post-LPI and 126 eyes of 126 normal subjects were included in this prospective study. All subjects underwent complete ophthalmic evaluation, A-scan biometry, and UBM. The anterior segment and angle parameters were measured quantitatively and compared in both groups using Student's t-test. Results The PACG patients had shorter axial length, shallower central anterior chamber depth anterior chamber depth (ACD), and anteriorly located lens when compared with normal subjects. Trabecular iris angle (TIA) was significantly narrow (5.73 ± 7.76°) in patients with PACG when compared with normal subjects (23.75 ± 9.38°). The angle opening distance at 500 μm from scleral spur (AOD 500), trabecular—ciliary process distance (TCPD), iris—ciliary process distance (ICPD), and iris—zonule distance (IZD) were significantly shorter in patients with PACG than in normal subjects (p < 0.0001). The iris lens angle (ILA), scleral—iris angle (SIA), and scleral—ciliary process angle (SCPA) were significantly narrower in patients with PACG than in normal subjects (p < 0.0001). The iris—lens contact distance (ILCD) was greater in PACG group than in normal (p = 0.001). Plateau iris was seen in 57/185 (30.8%) of the eyes. Anterior positioned ciliary processes were seen in 130/185 eyes (70.3%) of eyes. Conclusion In PACG patients, persistent apposition angle closure is common even after LPI, which could be due to anterior rotation of ciliary body and plateau iris and overcrowding of anterior segment due to shorter axial length and relative anterior lens position. How to cite this article Mansoori T, Balakrishna N. Anterior Segment Morphology in Primary Angle Closure Glaucoma using Ultrasound Biomicroscopy. J Curr Glaucoma Pract 2017;11(3):86-91.

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