Apoptotic and Proliferative Defects Characterize Ocular Development in a Microphthalmic BMP Model

2013 ◽  
Vol 54 (7) ◽  
pp. 4636 ◽  
Author(s):  
Curtis R. French ◽  
Tara R. Stach ◽  
Lindsey D. March ◽  
Ordan J. Lehmann ◽  
Andrew J. Waskiewicz
Keyword(s):  
Ocular Development

Inactivation of Smad4 leads to impaired ocular development and cataract formation

2010 ◽  
Vol 400 (4) ◽  
pp. 476-482 ◽  
Author(s):  
Ying Liu ◽  
Kirio Kawai ◽  
Shabnam Khashabi ◽  
Chuxia Deng ◽  
Yi-Hsin Liu ◽  
...  
Keyword(s):  
Cataract Formation ◽  
Ocular Development

scholarly journals Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Mingsen Li ◽  
Liqiong Zhu ◽  
Jiafeng Liu ◽  
Huaxing Huang ◽  
Huizhen Guo ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Corneal Epithelium ◽  
Corneal Ulcer ◽  
Corneal Epithelial ◽  
Ocular Development ◽  
Rieger Syndrome ◽  
Corneal Ulcers ◽  
Epithelial Homeostasis ◽  
Forkhead Box ◽  
Interferon Regulatory Factor 1

AbstractForkhead box C1 (FOXC1) is required for neural crest and ocular development, and mutations in FOXC1 lead to inherited Axenfeld–Rieger syndrome. Here, we find that FOXC1 and paired box 6 (PAX6) are co-expressed in the human limbus and central corneal epithelium. Deficiency of FOXC1 and alternation in epithelial features occur in patients with corneal ulcers. FOXC1 governs the fate of the corneal epithelium by directly binding to lineage-specific open promoters or enhancers marked by H3K4me2. FOXC1 depletion not only activates the keratinization pathway and reprograms corneal epithelial cells into skin-like epithelial cells, but also disrupts the collagen metabolic process and interferon signaling pathways. Loss of interferon regulatory factor 1 and PAX6 induced by FOXC1 dysfunction is linked to the corneal ulcer. Collectively, our results reveal a FOXC1-mediated regulatory network responsible for corneal epithelial homeostasis and provide a potential therapeutic target for corneal ulcer.

scholarly journals Rescuing ocular development in an anophthalmic pig by blastocyst complementation

2018 ◽  
Vol 10 (12) ◽  
Author(s):  
Hongyong Zhang ◽  
Jiaojiao Huang ◽  
Zechen Li ◽  
Guosong Qin ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Ocular Development ◽  
Blastocyst Complementation

scholarly journals Differential expression of the HMGN family of chromatin proteins during ocular development

2008 ◽  
Vol 8 (6) ◽  
pp. 433-437 ◽  
Author(s):  
Michelle M. Lucey ◽  
Yan Wang ◽  
Michael Bustin ◽  
Melinda K. Duncan
Keyword(s):  
Differential Expression ◽  
Ocular Development ◽  
Chromatin Proteins

Differential Gene Expression in Mouse Sclera during Ocular Development

2006 ◽  
Vol 47 (5) ◽  
pp. 1794 ◽  
Author(s):  
Jie Zhou ◽  
Eric F. Rappaport ◽  
John W. Tobias ◽  
Terri L. Young
Keyword(s):  
Gene Expression ◽  
Differential Gene Expression ◽  
Ocular Development ◽  
Differential Gene

scholarly journals Semaphorin3A regulates neural crest migration during ocular development

2008 ◽  
Vol 319 (2) ◽  
pp. 541-542
Author(s):  
Peter Y. Lwigale ◽  
Marianne Bronner-Fraser
Keyword(s):  
Neural Crest ◽  
Ocular Development ◽  
Neural Crest Migration
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