Analysis of Spectral-Domain Optical Coherence Tomography in Preterm Children: Retinal Layer Thickness and Choroidal Thickness Profiles

2012 ◽  
Vol 53 (11) ◽  
pp. 7201 ◽  
Author(s):  
Kyung-Ah Park ◽  
Sei Yeul Oh
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Choroidal Thickness ◽  
Spectral Domain ◽  
Retinal Layer ◽  
Optical Coherence ◽  
Preterm Children

Inner macular layer thickness by spectral domain optical coherence tomography in children and adults: a hospital-based study

2019 ◽  
Vol 103 (11) ◽  
pp. 1576-1583 ◽  
Author(s):  
Yung Ju Yoo ◽  
Jeong-Min Hwang ◽  
Hee Kyung Yang
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Male Gender ◽  
Spectral Domain ◽  
Retinal Layer ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Korean Children ◽  
Factors Associated ◽  
Sd Oct

PurposeTo establish the normative ranges of macular ganglion cell layer (mGCL) and macular inner plexiform layer (mIPL) thickness using Spectralis spectral domain optical coherence tomography (SD-OCT) (Heidelberg Engineering, Inc., Heidelberg, Germany) in both Korean children and adults, and to determine factors associated with mGCL and mIPL thickness.MethodsWe conducted a retrospective, observational study of 573 healthy subjects (5–70 years old) who underwent comprehensive ophthalmic examinations in a single institution. Each inner retinal layer thickness was measured using SD-OCT and automatic segmentation software. Cross-sectional analysis was used to evaluate the effect of gender, age and ocular parameters on mGCL and mIPL thickness. Normative ranges of mGCL and mIPL thickness according to age, gender and factors associated with mGCL and mIPL thickness were measured.ResultsThe mean mGCL and mIPL thickness were 40.6±2.8 and 33.8±2.0 µm, respectively. Determinants of inner sector mGCL thickness were circumpapillary retinal nerve fibre layer (cpRNFL) thickness (β=1.172, p<0.001), age (β=−0.019, p=0.021) and male gender (β=1.452, p<0.001). Determinants of inner sector mIPL thickness were cpRNFL (β=0.952, p<0.001) and male gender (β=1.163, p<0.001). The inner sector mGCL and mIPL thickness increased significantly with age in children (β=0.174, p=0.009 and β=0.115, p=0.013), and then decreased in adults (β=−0.070, p<0.001 and β=−0.024, p=0.032). In the case of outer sectors, mGCL and mIPL thickness were not significantly related to age and gender.ConclusionsThis study ensured a normative range of the mGCL and mIPL thickness using Spectralis OCT. Gender, age and cpRNFL thickness significantly correlated with mGCL and mIPL thickness. This information should be considered in the interpretation of SD-OCT data.

scholarly journals Effect of Age on Individual Retinal Layer Thickness in Normal Eyes as Measured With Spectral-Domain Optical Coherence Tomography

2013 ◽  
Vol 54 (7) ◽  
pp. 4934 ◽  
Author(s):  
Nazli Demirkaya ◽  
Hille W. van Dijk ◽  
Sanne M. van Schuppen ◽  
Michael D. Abràmoff ◽  
Mona K. Garvin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Spectral Domain ◽  
Retinal Layer ◽  
Optical Coherence ◽  
Effect Of Age

scholarly journals Correlation of retinal changes with choroidal changes in acute and recurrent central serous chorioretinopathy assessed by swept-source optical coherence tomography

2020 ◽  
Vol 12 ◽  
pp. 251584141989982
Author(s):  
Durgasri Jaisankar ◽  
Meenakshi Kumar ◽  
Pukhraj Rishi ◽  
Sumeer Singh ◽  
Rajiv Raman
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Central Serous Chorioretinopathy ◽  
Choroidal Thickness ◽  
Retinal Layer ◽  
Optical Coherence ◽  
Swept Source ◽  
Acute Group ◽  
Significant Difference

Purpose: To evaluate affected choroidal regions and corresponding retinal changes in acute and recurrent central serous chorioretinopathy using swept-source optical coherence tomography. Methods: The foveal and subfoveal choroidal thicknesses were measured with swept-source optical coherence tomography. The retina was divided into five zones on the swept-source optical coherence tomography image based on baseline choroidal thickness being <100, 100–199, 200–299, 300–399 and ⩾400 μm. The retinal and choroidal thicknesses in the same five regions were evaluated during follow-up. The measurements were then compared between baseline (when central serous chorioretinopathy was active) and follow-up (after complete resolution of disease). Results: At baseline, in the acute group, the mean outer retinal layer thickness was significantly higher in areas with thicker choroid and lower in areas with thinner choroid. No such change was noticed in the recurrent group. In the acute group, the overall retinal thickness from baseline to follow-up decreased from 269.84 to 251.9 µm, ganglion cell layer thickness decreased from 107.14 to 101.28 µm, retinal nerve fibre layer thickness decreased from 56.96 to 49.33 µm, and no significant difference was noted in choroidal thickness. In the recurrent group, choroidal thickness significantly increased from 254.58 to 262.55 µm and ganglion cell layer decreased from 103.43 to 94.01 µm. No significant difference was noted in overall retina and retinal nerve fibre layer. Reduction in choroidal and retinal layer thicknesses was better in eyes which underwent laser treatment than the observation group. Conclusion: Swept-source optical coherence tomography might serve as an important non-invasive tool for both evaluating the extent of pathology and to predict the recurrence rate.

Systematic ultrastructural comparison of swept-source and full-depth spectral domain optical coherence tomography imaging of diabetic macular oedema

2019 ◽  
Vol 104 (6) ◽  
pp. 868-873 ◽  
Author(s):  
Christoph Mitsch ◽  
Jan Lammer ◽  
Sonja Karst ◽  
Christoph Scholda ◽  
Eleonore Pablik ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Macular Oedema ◽  
Diabetic Macular Oedema ◽  
Spectral Domain ◽  
Retinal Layer ◽  
Systematic Bias ◽  
Optical Coherence ◽  
Swept Source ◽  
Sd Oct

Background/AimsOptical coherence tomography (OCT) is commonly used to diagnose and assess diabetic macular oedema (DME). Swept-source OCT (SS-OCT) promises improved imaging depth and more independence from media opacities. Heidelberg Spectralis full-depth imaging (FDI) combines details at different depths to one representation. The aim of this study was to determine the comparability of the imaging methods concerning DME ultrastructure.MethodsTwo graders assessed the presence of typical DME phenomena in eyes with centre-involving DME on Topcon Atlantis SS-OCT and Heidelberg Spectralis FDI spectral-domain OCT (SD-OCT) B-scans. Retinal layer segmentation was corrected and choroidal layers were manually segmented. Graders measured cyst and subretinal fluid (SRF) diameters and counted hyper-reflective foci (HRF). Findings were recorded and statistically analysed.ResultsStatistically significant systematic biases (Spectralis-Atlantis) were found for the HRF count (outside the central mm, −6.39, p=0.0338), chorioretinal thickness (central mm: −35.45 µm, p=0.00034), choroidal thickness (central mm: −60.97 µm, p=0.00004) and Sattler’s layer thickness (−42.69 µm, p=0.0001). Intergrader agreement was excellent or very good for posterior vitreous detachment, vitreomacular attachment (central mm) and SRF presence in both devices. Manually delineated Sattler’s layer thickness showed an intraclass correlation of 0.85 with FDI SD-OCT but 0.26 with SS-OCT (p=0.003).ConclusionProminent aspects such as cysts in the outer nuclear layer and SRF can be identified with comparable confidence, while a significant systematic bias underlies chorioretinal, choroidal and Sattler’s layer thickness and HRF count. Specialists should use the same device at every examination during longitudinal clinical consideration or cross-sectional evaluation of these ultrastructural biomarkers.

Spectral Domain Optical Coherence Tomography of Choroidal and Outer Retinal Layer Thickness in the Sturge Weber Syndrome

2016 ◽  
Vol 41 (12) ◽  
pp. 1614-1617 ◽  
Author(s):  
Solmaz Abdolrahimzadeh ◽  
Vittorio Scavella ◽  
Domenica Battaglia ◽  
Santi Maria Recupero
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Spectral Domain ◽  
Retinal Layer ◽  
Optical Coherence ◽  
Weber Syndrome ◽  
Sturge Weber Syndrome

scholarly journals Geographic mapping of choroidal thickness in myopic eyes using 1050-nm spectral domain optical coherence tomography

2015 ◽  
Vol 08 (04) ◽  
pp. 1550012 ◽  
Author(s):  
Qinqin Zhang ◽  
Maureen Neitz ◽  
Jay Neitz ◽  
Ruikang K. Wang
Keyword(s):  
Optical Coherence Tomography ◽  
High Myopia ◽  
Choroidal Thickness ◽  
Retinal Pigment ◽  
Reduction Rate ◽  
Radial Distance ◽  
Spectral Domain ◽  
Temporal Region ◽  
Optical Coherence ◽  
The Mean

Purpose: To provide a geographical map of choroidal thickness (CT) around the macular region among subjects with low, moderate and high myopia. Methods: 20 myopic subjects (n = 40 eyes) without other identified pathologies participated in this study: 20 eyes of ≤ 3 diopters (D) (low myopic), 10 eyes between -3 and -6D (moderate myopic), and 10 eyes of ≥ 6D (high myopic). The mean age of subjects was 30.2 years (± 7.6 years; range, 24 to 46 years). A 1050 nm spectral-domain optical coherence tomography (SD-OCT) system, operating at 120 kHz imaging rate, was used in this study to simultaneously capture 3D anatomical images of the choroid and measure intraocular length (IOL) in the subject. The 3D OCT images of the choroid were segmented into superior, inferior, nasal and temporal quadrants, from which the CT was measured, representing radial distance between the outer retinal pigment epithelium (RPE) layer and inner scleral border. Measurements were made within concentric regions centered at fovea centralis, extended to 5 mm away from fovea at 1 mm intervals in the nasal and temporal directions. The measured IOL was the distance from the anterior cornea surface to the RPE in alignment along the optical axis of the eye. Statistical analysis was performed to evaluate CT at each geographic region and observe the relationship between CT and the degree of myopia. Results: For low myopic eyes, the IOL was measured at 24.619 ± 0.016 mm. The CT (273.85 ± 49.01 μm) was greatest under fovea as is in the case of healthy eyes. Peripheral to the fovea, the mean CT decreased rapidly along the nasal direction, reaching a minimum of 180.65 ± 58.25μm at 5 mm away from the fovea. There was less of a change in thickness from the fovea in the temporal direction reaching a minimum of 234.25 ± 42.27 μm. In contrast to the low myopic eyes, for moderate and high myopic eyes, CTs were thickest in temporal region (where CT = 194.94 ± 27.28 and 163 ± 34.89 μm, respectively). Like the low myopic eyes, moderate and high myopic eyes had thinnest CTs in the nasal region (where CT = 100.84 ± 16.75 and 86.64 ± 42.6μm, respectively). High myopic eyes had the longest mean IOL (25.983 ± 0.021mm), while the IOL of moderate myopia was 25.413 ± 0.022 mm (**p < 0.001). The CT reduction rate was calculated at 31.28 μm/D (diopter) from low to moderate myopia, whilst it is 13.49 μm/D from moderate to high myopia. The similar tendency was found for the IOL reduction rate in our study: 0.265 mm/D from low to moderate myopia, and 0.137 mm/D from moderate to high myopia. Conclusion: The CT decreases and the IOL increases gradually with the increase of myopic condition. The current results support the theory that choroidal abnormality may play an important role in the pathogenesis of myopic degeneration.

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