Capsaicin-Induced Corneal Sensory Denervation and Healing Impairment Are Reversed by NGF Treatment

2012 ◽  
Vol 53 (13) ◽  
pp. 8280 ◽  
Author(s):  
Alessandro Lambiase ◽  
Luigi Aloe ◽  
Flavio Mantelli ◽  
Marta Sacchetti ◽  
Eleonora Perrella ◽  
...  
Keyword(s):  
Sensory Denervation ◽  
Healing Impairment

Su1746 Pathogenesis of Steroid-Induced Gastric Ulceration in Rats: Involvement of Prostaglandin Deficiency, Pepsin Secretion, and Healing Impairment Action

2012 ◽  
Vol 142 (5) ◽  
pp. S-494
Author(s):  
Aya Yamaguchi ◽  
Shusaku Hayashi ◽  
Yuka Ishikawa ◽  
Shino Kunimi ◽  
Kikuko Amagase ◽  
...  
Keyword(s):  
Gastric Ulceration ◽  
Pepsin Secretion ◽  
Healing Impairment

Severe Wound Healing Impairment in a Patient with Dysfibrinogenaemia

2018 ◽  
Vol 118 (02) ◽  
pp. 430-432 ◽  
Author(s):  
Lize van Vulpen ◽  
Shwan Amin ◽  
Michael Makris
Keyword(s):  
Wound Healing ◽  
Healing Impairment

A Novel Technical Protocol for Improved Capture of the Genicular Nerves by Radiofrequency Ablation

Pain Medicine ◽  
2019 ◽  
Vol 20 (11) ◽  
pp. 2208-2212 ◽  
Author(s):  
Aaron Conger ◽  
Daniel M Cushman ◽  
Kortnie Walker ◽  
Russell Petersen ◽  
David R Walega ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Anatomic Variation ◽  
Vastus Lateralis ◽  
Tendon Injury ◽  
Sensory Nerves ◽  
Sensory Innervation ◽  
Vastus Intermedius ◽  
Technical Report ◽  
Sensory Denervation ◽  
Anterior Knee

Abstract Background Fluoroscopically guided cooled genicular nerve radiofrequency ablation (RFA) is an increasingly performed procedure for chronic, refractory knee pain due to osteoarthritis. Traditionally, partial sensory denervation has been accomplished through ablation of the superomedial, superolateral, and inferomedial genicular nerves. However, recent cadaveric studies have demonstrated additional sensory nerves and significant anatomic variation that impact current protocols. Objective We describe an updated cooled genicular nerve radiofrequency ablation protocol that accounts for varied nerve location of the superomedial, superolateral, and inferomedial genicular nerves, as well as capture of the terminal articular branches of the nerves to the vastus intermedius, vastus lateralis, and vastus medialis. Furthermore, we describe an adjusted technique for inferomedial genicular nerve capture that mitigates the risk of pes anserine tendon injury. Design Technical report and brief literature review. Methods Cadaveric studies relating to the sensory innervation of the anterior knee joint were reviewed, and a more accurate and comprehensive cooled genicular nerve radiofrequency ablation (CRFA) protocol is proposed. Conclusions Based on recent, rigorous anatomic dissections of the knee, the proposed genicular nerve CRFA protocol will provide more complete sensory denervation and potentially improve clinical outcomes. Prospective studies will be needed to confirm the hypothesis that this protocol will result in improved effectiveness and safety of genicular nerve RFA.

Application of Basic Fibroblast Growth Factor May Reverse Diabetic Wound Healing Impairment

1993 ◽  
Vol 31 (4) ◽  
pp. 331-334 ◽  
Author(s):  
Linda G. Phillips ◽  
Kay M. Abdullah ◽  
Peter D. Geldner ◽  
Stewart Dobbins ◽  
Francis Ko ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Healing Impairment

Absence of Healing Impairment in Osteotomies Prepared via Osseodensification Drilling

2019 ◽  
Vol 39 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Lukasz Witek ◽  
Rodrigo Neiva ◽  
Adham Alifarag ◽  
Farnaz Shahraki ◽  
Ghazaleh Sayah ◽  
...  
Keyword(s):  
Healing Impairment

Luminal dilution caused by certain mild irritants and capsaicin contributes to their gastric mucosal protection

1995 ◽  
Vol 268 (2) ◽  
pp. G200-G206
Author(s):  
Y. Hatakeyama ◽  
M. Matsuo ◽  
M. Tomoi ◽  
M. Ohtsuka ◽  
K. Shimomura
Keyword(s):  
Gastric Lesion ◽  
Mucosal Injury ◽  
Gastric Fluid ◽  
Fluid Volume ◽  
Phenol Red ◽  
Gastric Cavity ◽  
Volume Increase ◽  
Gastric Fluid Volume ◽  
Sensory Denervation ◽  
Mild Irritants

We have recently shown that certain mild irritants caused the increase in fluid volume in the rat stomach. The present study was conducted to investigate 1) whether standing fluid in the gastric cavity can prevent gastric mucosal injury caused by 0.6 N HCl and 2) the mechanisms by which certain mild irritants increase the gastric fluid volume. One milliliter of water administered immediately before irritants greatly inhibited gastric lesion formation. Sodium chloride and capsaicin induced a profound enhancement of gastric fluid volume, as acid mild irritants did also. Sensory denervation completely abolished the volume increase caused by capsaicin but hardly influenced that caused by mild irritants. Capsaicin increased the amount of Evans blue in the gastric fluid, but mild irritants did not. On the other hand, HCl and capsaicin significantly inhibited the emptying of phenol red. From these results, we conclude that mild irritants and capsaicin can induce volume increase that by itself is enough to afford protection through luminal dilution. Capsaicin but not mild irritants requires sensory neurons to increase the gastric fluid volume. Certain mild irritants may provide a fluid pooling effect partly by inhibiting gastric emptying.

Effects of sensory denervation by neonatal capsaicin administration on experimental pancreatitis induced by dibutyltin dichloride

2007 ◽  
Vol 40 (3) ◽  
pp. 141-149 ◽  
Author(s):  
Tsukasa Ikeura ◽  
Yosky Kataoka ◽  
Taketoshi Wakabayashi ◽  
Tetsuji Mori ◽  
Yasuharu Takamori ◽  
...  
Keyword(s):  
Experimental Pancreatitis ◽  
Dibutyltin Dichloride ◽  
Sensory Denervation

scholarly journals The Reversal of an Adriamycin® Induced Healing Impairment with Chemoattractants and Growth Factors

1986 ◽  
Vol 203 (2) ◽  
pp. 142-147 ◽  
Author(s):  
W. THOMAS LAWRENCE ◽  
MICHAEL B. SPORN ◽  
CATHERINE GORSCHBOTH ◽  
JEFFREY A. NORTON ◽  
GARY R. GROTENDORST
Keyword(s):  
Growth Factors ◽  
Healing Impairment

Age related sprouting of dorsal root axons after sensory denervation

1983 ◽  
Vol 288 (1-2) ◽  
pp. 77-83 ◽  
Author(s):  
Claire E. Hulsebosch ◽  
Richard E. Coggeshall
Keyword(s):  
Dorsal Root ◽  
Age Related ◽  
Sensory Denervation
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