Genetic Characterization and Susceptibility for Sarcoidosis in Japanese Patients: Risk Factors ofBTNL2Gene Polymorphisms and HLA Class II Alleles

2012 ◽  
Vol 53 (11) ◽  
pp. 7109 ◽  
Author(s):  
Hitomi Suzuki ◽  
Masao Ota ◽  
Akira Meguro ◽  
Yoshihiko Katsuyama ◽  
Tatukata Kawagoe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Characterization ◽  
Japanese Patients ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hla Class Ii Alleles

scholarly journals HLA Class II Alleles in Japanese Patients with Graves' Disease: Weak Associations of HLA-DR and -DQ.

1994 ◽  
Vol 41 (6) ◽  
pp. 599-603 ◽  
Author(s):  
EIYU KATSUREN ◽  
TAKUYA AWATA ◽  
CHIAKI MATSUMOTO ◽  
KUNIHIRO YAMAMOTO
Keyword(s):  
Japanese Patients ◽  
Class Ii ◽  
Hla Class Ii ◽  
Graves Disease ◽  
Hla Dr ◽  
Hla Class Ii Alleles

Multicenter cooperative study of HLA class II alleles in Japanese patients with systemic lupus erythematosus

2000 ◽  
Vol 10 (4) ◽  
pp. 235-239 ◽  
Author(s):  
S. Morimoto ◽  
H. Hashimoto ◽  
K. Yamanaka ◽  
Y. Tokano ◽  
Y. Nishimura ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Japanese Patients ◽  
Class Ii ◽  
Hla Class Ii ◽  
Cooperative Study ◽  
Systemic Lupus ◽  
Hla Class Ii Alleles

HLA class II alleles in Japanese patients with inflammatory bowel disease

1999 ◽  
Vol 53 (4) ◽  
pp. 350-358 ◽  
Author(s):  
S. Yoshitake ◽  
A. Kimura ◽  
M. Okada ◽  
T. Yao ◽  
T. Sasazuki
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Japanese Patients ◽  
Class Ii ◽  
Hla Class Ii ◽  
Inflammatory Bowel ◽  
Hla Class Ii Alleles

Molecular genetic analysis of HLA class II alleles in Japanese patients with melanoma

1997 ◽  
Vol 49 (5) ◽  
pp. 466-470 ◽  
Author(s):  
T. Kageshila ◽  
T. Naruse ◽  
S. Hiral ◽  
T. Ono ◽  
T. Horikoshi ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Molecular Genetic ◽  
Japanese Patients ◽  
Class Ii ◽  
Molecular Genetic Analysis ◽  
Hla Class Ii ◽  
Hla Class Ii Alleles

MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciprum

1992 ◽  
Vol 4 (9) ◽  
pp. 1055-1063 ◽  
Author(s):  
E. M. Riley ◽  
O. Olerup ◽  
S. Bennett ◽  
P. Rowe ◽  
S. J. Allen ◽  
...  
Keyword(s):  
Immune Responses ◽  
Class Ii ◽  
Hla Class Ii ◽  
The Relationship ◽  
Hla Class Ii Alleles

Susceptibility to IDDM in a Chinese Population: Role of HLA Class II Alleles

Diabetes ◽  
1992 ◽  
Vol 41 (8) ◽  
pp. 914-919 ◽  
Author(s):  
M. A. Penny ◽  
D. Jenkins ◽  
C. H. Mijovic ◽  
K. H. Jacobs ◽  
D. A. Cavan ◽  
...  
Keyword(s):  
Chinese Population ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hla Class Ii Alleles

scholarly journals HLA class II antigens and haplotypes associated with susceptibility of leukemias and myelodysplastic syndrome

Genetika ◽  
2011 ◽  
Vol 43 (2) ◽  
pp. 361-370
Author(s):  
Svetlana Vojvodic ◽  
Dusica Ademovic-Sazdanic
Keyword(s):  
Risk Factors ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukemia ◽  
Hla Antigens ◽  
Positive Association ◽  
Class Ii ◽  
Hla Class Ii ◽  
Negative Association ◽  
Male Patients ◽  
Class Ii Antigens

Genetical and environmental factors play an interactive role in the development of acute and chronic leukemias. HLA antigens have been considered as possible genetic risk factors. The aim of this work was to investigate a possible association between HLA class II polymorphisms and leukemias and myelodysplastic syndrome. In the present study we investigated HLA class II antigens, DR/DQ and DR51/DR52/DR53 haplotypes in 100 patients: 7 suffering from myelodysplastic syndrome (MDS),37 from acute lymphoblastic leukemia(ALL),32 from acute myeloid leukemia (AML) and 24 from chronic myeloid leukemia(CML). A panel of 210 healthy unrelated individuals of the same origin, from Vojvodina, served as controls. HLA phenotyping was performed by two color fluorescence method. In patients suffering from MDS was found a positive association with DR7(RR=2.598,EF=0.175) and DQ7(3)(RR=4.419, EF=0.632), while negative association was found for DR15(2)(RR=0.405, PF=0.172) and DQ6(1) (RR=0.889, PF=0,936).Positive association was found in the group of patients with ALL for DR7(RR=2.391,EF=0.688) and DQ2(RR=1.62, EF=0.15),while negative association was found with DQ5(1)(RR=0.075, PF=0.324). In the group of patients with AML, there were positive associations with DR11(5)(RR=1.732,EF=0.211),DQ2(RR= 1.594, EF=0.151) and DQ7(3) (RR=2.547,EF=0.266),while possible protective antigen was DQ5(1) (RR=0.107,RF=0.701). Higher RR than 1 and EF>0.15, in patients suffering from CML was found for DQ6(1)(RR=1.661,EF=0.232), while negative association was found for DR4 (RR=0.182,PF=0.155).Possible protective haplotype in this study was DR3DQ8(3) for patients suffering from AML(RR=0.007, PF=0.501).The distribution of DR53-DR53 haplotypes showed significant difference in male patients with ALL(6% vs 0.09%), while DR52-DR52 haplotype was significantly less frequent in male patients with CML (4% vs 20.47%) and female patients with MDS (1% vs 18.57%), respectively, in comparison to controls. We deduced that DR7 antigen in male patients with ALL has the greatest impact to the higher frequency of DR53-DR53 haplotype in this type of leukemia. The role of HLA antigens as risk factors for development of leukemias in our population was shown and furthermore it could be useful in clinical practice.

scholarly journals CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation

Blood ◽  
2016 ◽  
Vol 128 (17) ◽  
pp. 2165-2174 ◽  
Author(s):  
Cor H. J. Lamers ◽  
Rebecca Wijers ◽  
Cornelis A. M. van Bergen ◽  
Judith A. E. Somers ◽  
Eric Braakman ◽  
...  
Keyword(s):  
T Cells ◽  
Cord Blood Transplantation ◽  
Class Ii ◽  
Hla Class Ii ◽  
Effector T Cells ◽  
Cd4 T Cell ◽  
Blood Transplantation ◽  
Key Points ◽  
Allele Specific ◽  
Hla Class Ii Alleles

Key Points Graft-versus-graft alloreactivity after dUCBT involves recognition of mismatched HLA class II alleles by allele-specific CD4+ effector T cells. Alloreactive donor CD4+ T cells may recognize recipient leukemia if mismatched for individual HLA class II alleles.

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