scholarly journals RPGR-Associated Retinal Degeneration in Human X-Linked RP and a Murine Model

2012 ◽  
Vol 53 (9) ◽  
pp. 5594 ◽  
Author(s):  
Wei Chieh Huang ◽  
Alan F. Wright ◽  
Alejandro J. Roman ◽  
Artur V. Cideciyan ◽  
Forbes D. Manson ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Murine Model

scholarly journals Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration

2014 ◽  
Vol 94 (6) ◽  
pp. 674-682 ◽  
Author(s):  
Yujuan Wang ◽  
Mones S Abu-Asab ◽  
Cheng-Rong Yu ◽  
Zhongshu Tang ◽  
Defen Shen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Retinal Degeneration ◽  
Murine Model ◽  
Platelet Derived Growth Factor

scholarly journals Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model

2012 ◽  
Vol 9 (1) ◽  
Author(s):  
Jingsheng Tuo ◽  
Xiaoguang Cao ◽  
Defen Shen ◽  
Yujuan Wang ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Murine Model ◽  
Anti Inflammatory

scholarly journals Intravitreal Administration of Human Bone Marrow CD34+ Stem Cells in a Murine Model of Retinal Degeneration

2016 ◽  
Vol 57 (10) ◽  
pp. 4125 ◽  
Author(s):  
Elad Moisseiev ◽  
Zeljka Smit-McBride ◽  
Sharon Oltjen ◽  
Pengfei Zhang ◽  
Robert J. Zawadzki ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Retinal Degeneration ◽  
Murine Model ◽  
Human Bone ◽  
Human Bone Marrow

Effect of AAV-Mediated Rhodopsin Gene Augmentation on Retinal Degeneration Caused by the Dominant P23H Rhodopsin Mutation in a Knock-In Murine Model

2020 ◽  
Vol 31 (13-14) ◽  
pp. 730-742 ◽  
Author(s):  
Harry O. Orlans ◽  
Alun R. Barnard ◽  
Maria I. Patrício ◽  
Michelle E. McClements ◽  
Robert E. MacLaren
Keyword(s):  
Retinal Degeneration ◽  
Murine Model ◽  
Rhodopsin Gene

scholarly journals Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Deokho Lee ◽  
Ayaka Nakai ◽  
Yukihiro Miwa ◽  
Yohei Tomita ◽  
Naho Serizawa ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Retinal Degeneration ◽  
Murine Model ◽  
Common Carotid Artery ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Ischemia ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Common Carotid Artery Occlusion

Retinal degeneration is a progressive retinal damage in ocular vascular diseases. There are several reasons for this, such as occlusion of arteries or veins, diabetic retinopathy, or hereditary retinal diseases. To study pathological mechanisms of retinal degeneration, it is required to develop experimentally reproducible and clinically relevant models. In our previous studies, we developed a murine model of retinal hypoperfusion by unilateral common carotid artery occlusion (UCCAO) which mimics the pathophysiology of ocular ischemic syndrome (OIS) in humans, and described broad pathological mechanisms in the retina after UCCAO. However, there still remain missing pieces of the ocular pathologic process by UCCAO. In this study, we examined those unfound mechanisms. UCCAO was performed on adult mice. Ocular dysfunctions, histological deficits, and inflammation were examined after UCCAO, compared with sham-operated mice. Evaluation values were analyzed by electrophysiological, histological, and molecular biological methods. Eyelid drooping was permanently seen after UCCAO. Induction time point of acute reversible cataract under anesthesia was shortened. Retinal/visual dysfunctions were detected 2-4 weeks after UCCAO. Specifically, scotopic b-wave was more affected than a-wave, with the dysfunction of photopic b-wave. Impaired oscillatory potentials and visual evoked potential were constantly observed. Pathological Müller gliosis/inflammation was featured with NeuN-positive cell loss in the ganglion cell layer. Axial length, intraocular pressure, pupillary light reflex, and retinal pigment epithelium/choroidal thickness were not changed by UCCAO. A murine model of retinal ischemia by UCCAO can be useful for studying a series of degenerative process in the ischemic retina.

Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma

2015 ◽  
Vol 588 ◽  
pp. 108-113 ◽  
Author(s):  
Atsuko Kimura ◽  
Xiaoli Guo ◽  
Takahiko Noro ◽  
Chikako Harada ◽  
Kohichi Tanaka ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Retinal Degeneration ◽  
Murine Model ◽  
Normal Tension Glaucoma
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