Quantification of Retinal Neural Loss in Patients with Neuromyelitis Optica and Multiple Sclerosis with or without Optic Neuritis Using Fourier-Domain Optical Coherence Tomography

2012 ◽  
Vol 53 (7) ◽  
pp. 3959 ◽  
Author(s):  
Mário L. R. Monteiro ◽  
Danilo B. Fernandes ◽  
Samira L. Apóstolos-Pereira ◽  
Dagoberto Callegaro
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Fourier Domain ◽  
Optical Coherence

scholarly journals Optical Coherence Tomography Angiography of Peripapillary Vessel Density in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Comparative Study

2021 ◽  
Vol 10 (4) ◽  
pp. 609
Author(s):  
Małgorzata Rogaczewska ◽  
Sławomir Michalak ◽  
Marcin Stopa
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
Spectrum Disorder ◽  
Control Group ◽  
Optical Coherence ◽  
Neuromyelitis Optica Spectrum Disorder

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are demyelinating diseases of the central nervous system, which differ in the pathogenic mechanism. A common clinical presentation of both conditions is optic neuritis (ON). The study aimed to compare the radial peripapillary capillary (RPC) vessel density in MS and NMOSD patients using optical coherence tomography angiography (OCTA). A total of 40 MS patients, 13 NMOSD patients, and 20 controls were included. The average RPC vessel density was significantly lower in ON eyes (MS+ON, NMOSD+ON) than in non-ON eyes (MS−ON, NMOSD−ON) and in MS+ON, MS−ON, NMOSD+ON, and NMOSD−ON compared with the control group. In NMOSD+ON eyes, the vessel density in superior nasal, nasal superior, and inferior sectors was significantly more decreased than in MS+ON eyes. RPC reduction was also observed in inferior nasal and temporal superior sectors in MS−ON eyes compared with NMOSD−ON eyes. In conclusion, our findings indicate that optic neuritis is associated with a more significant RPC vessel density drop in NMOSD than in MS patients, and the predilection to superior and inferior sectors may be useful as a differential diagnostic marker.

A comparative optical coherence tomography study in neuromyelitis optica spectrum disorder and multiple sclerosis

2015 ◽  
Vol 21 (14) ◽  
pp. 1781-1793 ◽  
Author(s):  
Olivier Outteryck ◽  
Bilal Majed ◽  
Sabine Defoort-Dhellemmes ◽  
Patrick Vermersch ◽  
Hélène Zéphir
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Ganglion Cell ◽  
Neuromyelitis Optica ◽  
Spectrum Disorder ◽  
Imaging Biomarkers ◽  
Ganglion Cell Complex ◽  
Optical Coherence ◽  
Neuromyelitis Optica Spectrum Disorder

Objectives: The aim of this study was to find, using spectral domain-optical coherence tomography (SD-OCT), retinal imaging biomarkers differentiating neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS) and healthy controls (HCs). Materials and methods: The population was composed of patients with NMOSD ( n=23) or MS ( n=110) and of HCs ( n=75). Evaluation criteria were retinal thickness/volume, visual acuity, low contrast vision acuity and Expanded Disability Status Scale score. Results: Considering all eyes and after statistical adjustments including the number of optic neuritis (ON) episodes, we found that NMOSD patients did not have significantly more retinal atrophy than MS patients; whereas MS non-optic neuritis (NON) eyes had thinner temporal ( p=0.032) and temporo-superior peripapillary retinal nerve fibre layer (pRNFL; p=0.011) thicknesses than NMOSD NON eyes; in addition, NMOSD NON eyes presented significant naso-inferior pRNFL ( p=0.024), temporal pRNFL ( p=0.039), macular ganglion cell complex ( p=0.004) and ganglion cell layer ( p=0.002) atrophy vs HC eyes. We identified significant correlations between visual and clinical disability and retinal thicknesses in both diseases. Conclusion: OCT may help to differentiate NMOSD and MS by focusing on the NON eyes (temporal pRNFL atrophy more severe in MS). Moreover, we discuss the possibility of a retinal degenerative process independent of ON in NMOSD.

scholarly journals Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

2015 ◽  
Vol 21 (6) ◽  
pp. 678-688 ◽  
Author(s):  
JL Bennett ◽  
J de Seze ◽  
M Lana-Peixoto ◽  
J Palace ◽  
A Waldman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Water Channel ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Specific Serum ◽  
The Central Nervous System ◽  
Inflammatory Autoimmune Disease

Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients’ RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

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