Photoreceptor and Post-Photoreceptoral Contributions to Photopic ERG a-Wave in Rhodopsin P347L Transgenic Rabbits

2012 ◽  
Vol 53 (3) ◽  
pp. 1467 ◽  
Author(s):  
Rika Hirota ◽  
Mineo Kondo ◽  
Shinji Ueno ◽  
Takao Sakai ◽  
Toshiyuki Koyasu ◽  
...  
Keyword(s):  
Transgenic Rabbits ◽  
Photopic Erg

2443 Photoreceptor And Post-photoreceptoral Contributions To Photopic ERG A-wave In Rhodopsin P347L Transgenic Rabbits

SciVee ◽  
2012 ◽  
Author(s):  
Rika Hirota ◽  
Mineo Kondo ◽  
Shinji Ueno ◽  
Takao Sakai ◽  
Toshiyuki Koyasu ◽  
...  
Keyword(s):  
Transgenic Rabbits ◽  
Photopic Erg

Inhibition of Atherosclerosis Development in Cholesterol-Fed Human Apolipoprotein A-I–Transgenic Rabbits

Circulation ◽  
1996 ◽  
Vol 94 (4) ◽  
pp. 713-717 ◽  
Author(s):  
Nicolas Duverger ◽  
Howard Kruth ◽  
Florence Emmanuel ◽  
Jean-Michel Caillaud ◽  
Ce´line Viglietta ◽  
...  
Keyword(s):  
Human Apolipoprotein ◽  
Apolipoprotein A ◽  
Transgenic Rabbits ◽  
Atherosclerosis Development

scholarly journals Transgenic rabbits as models for atherosclerosis research

1999 ◽  
Vol 40 (3) ◽  
pp. 365-375 ◽  
Author(s):  
Margaret E. Brousseau ◽  
Jeffrey M. Hoeg
Keyword(s):  
Transgenic Rabbits ◽  
Atherosclerosis Research

Morphology of Testes from Transgenic Rabbits: Histological and Ultrastructural Aspects

2010 ◽  
Vol 39 (1) ◽  
pp. 27-33 ◽  
Author(s):  
P. Chrenek ◽  
A. V. Makarevich ◽  
E. Kubovičová ◽  
J. Pivko
Keyword(s):  
Transgenic Rabbits

Abstract 1352: Gender Differences In Cardiac Repolarization In Transgenic Long QT Syndrome 2 (LQT2) Rabbits

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Katja E Odening ◽  
Mohammad Hajjiri ◽  
Michael Brunner ◽  
Peem Lorvidhaya ◽  
Lorraine Schofield ◽  
...  
Keyword(s):  
Gender Differences ◽  
Cardiac Repolarization ◽  
Adult Women ◽  
Male Adult ◽  
Clinical Events ◽  
Transgenic Rabbits ◽  
Surface Ecg ◽  
Electrophysiological Studies ◽  
Genotype Difference

Introduction: Adult women with LQT2 are at higher risk for clinical events and sudden cardiac death (SCD) than men. We have created transgenic rabbits over-expressing pore mutants of the human KvLQT1 (LQT1) and HERG (LQT2) selectively in the heart. We report the gender differences in cardiac repolarization, incidence of polymorphic VT and SCD in these cohorts. Methods: Adult female and male LQT1, LQT2, and littermate controls (ages 5 to 33 mo were similar in f/m, LQT2 were younger due to higher mortality) underwent telemetric ECG monitoring, surface ECG and in vivo electrophysiological studies under general anaesthesia with isoflurane (2–5%). Results: Monitoring data showed a steeper QT/RR slope in female (0.745 ± 0.05, n=4) than in male (0.513 ± 0.06, n=9; p<0.05) LQT2 rabbits. No significant gender differences were observed in QT/RR slopes in either LQT1 or WT rabbits. QT-, QTpeak-index and Tp-e were significantly longer in female than in male LQT2 rabbits (females, n=6: QT: 129.2% ± 3.9; QTp: 105.9% ± 2.1; Tp-e: 42.9ms ± 4.1 vs. males, n=8: QT: 117.5% ± 4.3; p<0.05; QTp: 93.5% ± 5.6, p<0.05; Tp-e: 29.5ms ± 2.9, p<0.02). EP studies revealed significantly longer atrial (AERP) and ventricular (VERP) refractory periods in LQT2 females compared to males (females, n=4: AERP: 143.3 ± 5.8 ms; VERP: 212.5 ± 22.2 ms vs. males, n=8: AERP: 102.5 ± 7.7 ms, p<0.01; VERP: 178.1 ± 7.8 ms, p<0.05). AERP and VERP were significantly longer in LQT2 females than in LQT1 females (LQT1 females, n=7: AERP: 101.4 ± 7.7 ms, p<0.01, VERP: 156.9 ± 6.2, p<0.001), whereas in male LQT rabbits this genotype difference was only found in VERP but not in AERP. Survival was significantly shorter in female LQT2 rabbits compared to LQT1 or WT controls, with 4 sudden deaths among 10 LQT2, 1 among 19 WT and no SCD in 13 LQT1 females (p<0.02). No gender difference was observed in mortality. All cases of SCD occurred after sexual maturation and two LQT2 females died during lactation. Monitoring revealed the cause of SCD was polymorphic VT. Conclusions: Monitoring of LQT rabbits reveal gender differences in LQT2 rabbits. QT/RR slope is steeper in female than in male adult LQT2 rabbits. AERP and VERP are longer in LQT2 females than in males. Finally, in LQT2 females, SCD was associated with lactation, but not pregnancy.

scholarly journals Recombinant Human Tissue Non-Specific Alkaline Phosphatase Successfully Counteracts Lipopolysaccharide Induced Sepsis in Mice

2015 ◽  
pp. 731-738 ◽  
Author(s):  
B. BENDER ◽  
M. BARANYI ◽  
A. KEREKES ◽  
L. BODROGI ◽  
R. BRANDS ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Intravenous Injection ◽  
Human Tissue ◽  
Molecular Mechanisms ◽  
Multiple Organ ◽  
Control Group ◽  
Intestinal Alkaline Phosphatase ◽  
Specific Alkaline Phosphatase ◽  
Transgenic Rabbits ◽  
Rabbit Milk

Sepsis is a life threatening condition that arises when the body's response to an infection injures its own tissues and organs. Sepsis can lead to shock, multiple organ failure and death especially if not recognized early and treated promptly. Molecular mechanisms underlying the systemic inflammatory response syndrome associated with sepsis are still not completely defined and most therapies developed to target the acute inflammatory component of the disease are insufficient. In this study we investigated a possibility of combating sepsis in a mouse model by intravenous treatment with recombinant human tissue non-specific alkaline phosphatase (rhTNAP) derived from transgenic rabbit milk. We induced sepsis in mice by intraperitoneal injection of LPS and three hours later treated experimental group of mice by intravenous injection with rhTNAP derived from transgenic rabbits. Such treatment was proved to be physiologically effective in this model, as administration of recombinant rhTNAP successfully combated the decrease in body temperature and resulted in increased survival of mice (80 % vs. 30 % in a control group). In a control experiment, also the administration of bovine intestinal alkaline phosphatase by intravenous injection proved to be effective in increasing survival of mice treated with LPS. Altogether, present work demonstrates the redeeming effect of the recombinant tissue non-specific AP derived from milk of genetically modified rabbits in combating sepsis induced by LPS.

Transgenic Rabbits to Prepare Pharmaceutical Proteins

2009 ◽  
pp. 65-75 ◽  
Author(s):  
Louis-Marie Houdebine ◽  
Geneviève Jolivet ◽  
Pierre-Jean Ripoll
Keyword(s):  
Pharmaceutical Proteins ◽  
Transgenic Rabbits
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