Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients with Age-Related Macular Degeneration

2011 ◽  
Vol 52 (11) ◽  
pp. 8174 ◽  
Author(s):  
Günther Weigert ◽  
Semira Kaya ◽  
Berthold Pemp ◽  
Stefan Sacu ◽  
Michael Lasta ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Optical Density ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Macular Pigment Optical Density ◽  
Age Related

scholarly journals Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration

2020 ◽  
Vol 9 (5) ◽  
pp. 1347 ◽  
Author(s):  
Norihiro Nagai ◽  
Sakiko Minami ◽  
Misa Suzuki ◽  
Hajime Shinoda ◽  
Toshihide Kurihara ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Optical Density ◽  
Outer Segment ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Segment Length ◽  
Macular Pigment Optical Density ◽  
Photoreceptor Outer Segment ◽  
Age Related ◽  
Fellow Eyes

To explore predisease biomarkers, which may help screen for the risk of age-related macular degeneration (AMD) at very early stages, macular pigment optical density (MPOD) and photoreceptor outer segment (PROS) length were analyzed. Thirty late AMD fellow eyes, which are at high risk and represent the predisease condition of AMD, were evaluated and compared with 30 age-matched control eyes without retinal diseases; there was no early AMD involvement in the AMD fellow eyes. MPOD was measured using MPS2® (M.E. Technica Co. Ltd., Tokyo, Japan), and PROS length was measured based on optical coherence tomography images. MPOD levels and PROS length in the AMD fellow eyes were significantly lower and shorter, respectively, than in control eyes. MPOD and PROS length were positively correlated in control eyes (R = 0.386; p = 0.035) but not in AMD fellow eyes. Twenty (67%) AMD fellow eyes met the criteria of MPOD < 0.65 and/or PROS length < 35 μm, while only five (17%) control eyes did. After adjusting for age and sex, AMD fellow eyes more frequently satisfied the definition (p < 0.001; 95% confidence interval, 3.50–60.4; odds ratio, 14.6). The combination of MPOD and PROS length may be a useful biomarker for screening predisease AMD patients, although further studies are required in this regard.

scholarly journals Macular pigment optical density in wet age-related macular degeneration among Indians

Eye ◽  
2012 ◽  
Vol 26 (8) ◽  
pp. 1052-1057 ◽  
Author(s):  
R Raman ◽  
S Biswas ◽  
K Vaitheeswaran ◽  
T Sharma
Keyword(s):  
Macular Degeneration ◽  
Optical Density ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Macular Pigment Optical Density ◽  
Age Related

scholarly journals Assessment of macular pigment optical density in patients with unilateral wet age-related macular degeneration: authors reply

2012 ◽  
Vol 90 (3) ◽  
pp. e236-e236
Author(s):  
Chrysanthi Tsika ◽  
Miltiadis K. Tsilimbaris ◽  
Maria Makridaki ◽  
Georgios Kontadakis ◽  
Sotiris Plainis ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Optical Density ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Macular Pigment Optical Density ◽  
Age Related

scholarly journals New Pathogenetic-Oriented Method of Treatment of the Dry Form of Age-Related Macular Degeneration.

2016 ◽  
Vol 23 (3) ◽  
Author(s):  
N. O. Dziuba ◽  
A. M. Sergienko
Keyword(s):  
Conservative Treatment ◽  
Macular Degeneration ◽  
Optical Density ◽  
Light Therapy ◽  
Macular Pigment ◽  
Low Energy ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Macular Pigment Optical Density ◽  
Age Related

Age-related macular degeneration (AMD) is a leading cause of irreversible loss of central vision in people over 60 years of age. One of the most important risk factors for AMD is decrease in macular pigment optical density (MPOD). Search for new possible ways of (MPOD) improvement in AMD treatment is very important.The objective of the research was to study the indices of macular pigment optical density in patients with the dry form of AMD after two courses of low-energy light therapy and conservative treatment.Material and methods. The main group (MG) included 87 patients (146 eyes) who underwent two courses of low-energy light therapy (LLT) in combination with two courses of conservative treatment in hospital for 10 days at intervals of six months each. The control group (CG) consisted of 75 patients (135 eyes) who underwent only two courses of conservative therapy in the hospital for 10 days at intervals of six months each. Observations were conducted before, after treatment, after 1, 3 and 6 months after each course of treatment. The total period of follow-up was 1 year. LLT was performed using the device Spektra Light (Canada). All patients were generally conducted eye examination. MPOD was measured using densitometer “Maculux praxis” (Germany) by heterochromatic flicker photometry.Results. MPOD index increased from 0.249 ± 0.011 units to 0.360 ± 0.016 units, by 0.111 ± 0.014 units (44.6%) in 1 month after the first course of treatment, up to 0.344 ± 0.015 units, by 0.095 ± 0.013 units (38.2%) after 3 months, up to 0.321 ± 0.014 units, by 0.072 ± 0.013 (28.9%) in 6 months (p<0.05) in patients of MG. Stabilization of the index from 0.248 ± 0.012 units before the treatment and 0.243 ± 0.011 6 months after the first course of treatment (p>0.05) occurred in patients of the KG. MPOD indices increased from 0.321 ± 0.014 units to 0.431 ± 0.017 units, by 0.110 ± 0.016 units (34.3%) in 1 month after the second course of treatment, up to 0.412 ± 0.017 units, by 0.091 ± 0.016 units (28.4%) in 3 months, and up to 0.388 ± 0.016 units, by 0.067 ± 0.015 (20.9%) in 6 months (p<0.05) in patients of the MG. Stabilization of the index from 0.243 ± 0.011 units before the treatment and 0.237 ± 0.011 in 6 months after the second course of treatment (p>0.05) was observed in patients of KG.Conclusions. 1. Statistically significant increase in macular pigment optical density from 0.249 ± 0.011 units to 0.388 ± 0.016, by 0.139 ± 0.014 units (by 55.8%) was noted in patients who underwent two courses of low-energy light therapy in combination with a course of conservative treatment. Macular pigment optical density index did not change in the patients in the control group. 2. Two courses of low-energy light therapy in combination with a course of conservative treatment increases the concentration of macular pigment, as evidenced by the increase in indices of macular pigment optical density in comparison with conservative treatment, during which indices stabilize. 

scholarly journals Comparison of macular pigment optical density in patients with dry and wet age-related macular degeneration

2017 ◽  
Vol 65 (6) ◽  
pp. 477 ◽  
Author(s):  
Mahmut Kaya ◽  
Ayhan Ozyurt ◽  
Nilufer Kocak ◽  
Pınar Akan ◽  
OzlemGursoy Calan ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Optical Density ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Macular Pigment Optical Density ◽  
Age Related

Reliability of colour perimetry to assess macular pigment optical density in age-related macular degeneration

2019 ◽  
Vol 30 (6) ◽  
pp. 1480-1486 ◽  
Author(s):  
Rosa M Coco-Martín ◽  
María Pichel-Mouzo ◽  
Itziar Fernández ◽  
María Plata-Cordero ◽  
Alberto Lopez-Miguel
Keyword(s):  
Macular Degeneration ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Optical Density ◽  
Coefficient Of Variation ◽  
Intraclass Correlation ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Macular Pigment Optical Density ◽  
Age Related

Background: The aim of this study was to determine the intra-session repeatability and inter-examiner reproducibility of the colour perimetry technique when assessing in vivo macular pigment optical density in age-related macular degeneration patients. Methods: Age-related macular degeneration patients were classified into four groups: early age-related macular degeneration, intermediate age-related macular degeneration, atrophic age-related macular degeneration and neovascular age-related macular degeneration after undergoing fundus photography (TRC 50DX type IA) and spectral-domain optical coherence tomography analysis (Topcon 3D-2000). Central fixation was confirmed in all patients using the MP-1 microperimeter (Nidek, Padua, Italy). To analyse repeatability, one examiner obtained three consecutive macular pigment optical density measures with MonCV3 device (Metrovision, Perenchies, France). To study agreement between two observers, a second examiner performed another macular pigment optical density measurement in random order. Within-subject standard deviation, coefficient of variation, and intraclass correlation coefficient data were obtained. Results: Fifty two (32 females and 20 males) consecutive age-related macular degeneration patients having a mean age of 71.5 ± 8.2 years were recruited. Six had early age-related macular degeneration, 25 had intermediate age-related macular degeneration, 10 had atrophic age-related macular degeneration and 11 had neovascular age-related macular degeneration. For repeatability, coefficient of variation values ranged from 22.3% (neovascular age-related macular degeneration) to 41.0% (atrophic age-related macular degeneration) and intraclass correlation coefficient values from 0.52 (intermediate age-related macular degeneration) to 0.79 (neovascular age-related macular degeneration). For agreement between two examiners, coefficient of variation values ranged from 20.1% (intermediate age-related macular degeneration) to 37.8% (neovascular age-related macular degeneration) and intraclass correlation coefficient values from 0.61 (neovascular age-related macular degeneration) to 0.80 (atrophic age-related macular degeneration). Conclusion: The reliability (intra-session repeatability and inter-examiner reproducibility) of colour perimetry technique to assess macular pigment optical density in age-related macular degeneration patients is only moderate. Thus, it cannot be recommended to be performed when evaluating and monitoring age-related macular degeneration patients in the daily clinic.

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